Jia Shin
@jia-shin1022.bsky.social
Research Associate II @ Palop Lab
Molecular and Cellular Biology - Neurobiology @ UC Berkeley
Molecular and Cellular Biology - Neurobiology @ UC Berkeley
I am thrilled to share our new preprint!
How do APOE4, the strongest risk factor of Alzheimer's (AD), and Aβ pathology synergistically interact to drive early dysfunction in the presymptomatic phase of AD?
It may seem quiet, but the brain is already changing.
www.biorxiv.org/content/10.1...
🧵1/
How do APOE4, the strongest risk factor of Alzheimer's (AD), and Aβ pathology synergistically interact to drive early dysfunction in the presymptomatic phase of AD?
It may seem quiet, but the brain is already changing.
www.biorxiv.org/content/10.1...
🧵1/
APOE4–Aβ synergy drives brain network dysfunction and neuronal lysosomal-ER proteostasis dysregulation a preclinical Alzheimer’s disease model
Amyloid-β (Aβ) and APOE4 represent two of the strongest pathological and genetic risk factors for Alzheimer’s disease (AD), but how these co-pathogens interact during preclinical stages remains undefi...
www.biorxiv.org
November 16, 2025 at 10:35 PM
I am thrilled to share our new preprint!
How do APOE4, the strongest risk factor of Alzheimer's (AD), and Aβ pathology synergistically interact to drive early dysfunction in the presymptomatic phase of AD?
It may seem quiet, but the brain is already changing.
www.biorxiv.org/content/10.1...
🧵1/
How do APOE4, the strongest risk factor of Alzheimer's (AD), and Aβ pathology synergistically interact to drive early dysfunction in the presymptomatic phase of AD?
It may seem quiet, but the brain is already changing.
www.biorxiv.org/content/10.1...
🧵1/