Jani Huuhtanen MD PhD
@jhuuhtanen.bsky.social
Postdoc at Ton Schumacher and Dan Landau labs learning what gets immune cells excited
Netherlands Cancer Institute, New York Genome Center and Weill Cornell
Netherlands Cancer Institute, New York Genome Center and Weill Cornell
We went to look for T cell specific responses in autoimmunity, but found NK cells instead. We studied aplastic anemia, one of the best characterized CD8+ T cell mediated AIDs with >200 samples with scRNA-seq, TCRseq, machine-learning; dig into the thread below (or Zenodo)!
Excited to share our work on T&NK cells in autoimmunity, now out in SciTranslMed! www.science.org/doi/10.1126/...
We explored cells driving autoimmunity, searched for pathogenic TCRs & used single-cell seq in cohort of >200 pts to track them in co-culture with target cells.
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We explored cells driving autoimmunity, searched for pathogenic TCRs & used single-cell seq in cohort of >200 pts to track them in co-culture with target cells.
1/
Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature
NK cells and CD8+ TEMRA cells expressing NK receptors and disease-associated T cell receptors may drive autoimmunity in aplastic anemia.
www.science.org
February 28, 2025 at 1:21 PM
We went to look for T cell specific responses in autoimmunity, but found NK cells instead. We studied aplastic anemia, one of the best characterized CD8+ T cell mediated AIDs with >200 samples with scRNA-seq, TCRseq, machine-learning; dig into the thread below (or Zenodo)!
Reposted by Jani Huuhtanen MD PhD
There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem):
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
Coupling antigens from multiple subtypes of influenza can broaden antibody and T cell responses
The seasonal influenza vaccine contains strains of viruses from distinct subtypes that are grown independently and then combined. However, most individuals exhibit a more robust response to one of the...
www.science.org
December 20, 2024 at 4:57 PM
There's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem):
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
www.science.org/doi/10.1126/...
Here's my thread explaining this work🧵
Designing TCR that recognize pMHC is though ... what if we could bypass TCRs altogether? Innovative two new studies design and validate pMHC binders from scratch with generative modeling - congrats Baker/Garcia and Jensen/Hadrup labs
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Design of high specificity binders for peptide-MHC-I complexes
Class I MHC molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance, and specific targeting of these peptide-MHC (pMHC) complexes could have consider...
www.biorxiv.org
December 10, 2024 at 5:22 AM
Designing TCR that recognize pMHC is though ... what if we could bypass TCRs altogether? Innovative two new studies design and validate pMHC binders from scratch with generative modeling - congrats Baker/Garcia and Jensen/Hadrup labs
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Jani Huuhtanen MD PhD
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
November 20, 2024 at 9:55 AM
Our new work!
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...
We show that T cell cross-reactivity can be reduced without modifying the TCR itself (by dramatically enhancing antigen discrimination).
Generation of T cells with reduced off-target cross-reactivities by engineering co-signalling receptors
www.biorxiv.org/content/10.1...