This was associated with mitochondrial dysfunction and structural changes. Substitution of ascorbic acid led to decreased H2O2 levels and improved cell survival. This offers a potential therapeutic approach for this #raredisease

HO-1 deficiency is a devastating disorder of redox metabolism with few therapeutic options. In two independent models, we observed increased hydrogen peroxide and decreased ascorbic acid levels despite upregulation of SVCT2, a key ascorbic acid transporter.

Umeå is such a lovely place!

Very happy to do so! And great to connect on here

Thanks a lot! Will keep these in mind.

Während meiner Zeit in Schweden im Winter Vitamin D. Ansonsten nichts.