Jerica Radez
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Jerica Radez
@jericaradez.bsky.social
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Research Clinical Psychologist @Oxford Health & Uni of Oxford
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October 10, 2025 at 7:08 PM
Reposted by Jerica Radez
braithwaiteat.bsky.social
We compared the single cell transcriptome profiles of 150K immune cells treated with 11 different simulations to multiple inflammatory disease profiles. This open resource can help in selecting more disease-relevant in vitro conditions for immune cells. doi.org/10.1101/2025...
🧪🧬🖥️ #immunosky #medsky
To help selection of the most appropriate in vitro stimulations to model diseases, we also compared the single cell transcriptome profiles of 150K immune cells treated with 11 different simulations to multiple inflammatory disease gene expression profiles. The top plots show the similarity between in vitro stimulations of human blood cells, and bulk RNA sequencing profiles of the blood cells from rheumatoid arthritis or systemic lupus erythematous. The bottom left plot shows clustering of single cell RNA profiles from systemic lupus erythematous, with the bottom right plot highlighting similarities in simulated immune cells.
July 6, 2025 at 11:52 AM