Jennifer Reed
@jenniferreed.bsky.social
Chair, Cardiac Rehabilitation | Scientist, Director: Exercise Physiology & ❤️ Health Lab @HeartInstitute | Associate Professor @uOttawa
8. We hope that by sharing these findings, it will help inform future, successful trials. A thank you to the Co-PIs, Co-Is, and co-authors for their diligent and responsive efforts to see this trial and manuscript through.
May 23, 2025 at 3:29 PM
8. We hope that by sharing these findings, it will help inform future, successful trials. A thank you to the Co-PIs, Co-Is, and co-authors for their diligent and responsive efforts to see this trial and manuscript through.
3️⃣ intervention: consider shorter duration interventions (<12weeks) and those offered sooner following listing.
4️⃣ sample size: consider up to 30% drop-out.
5️⃣ identify funding or logistical (e.g. virtual) opportunities to address reported barriers to participation (e.g. travel costs & distance).
4️⃣ sample size: consider up to 30% drop-out.
5️⃣ identify funding or logistical (e.g. virtual) opportunities to address reported barriers to participation (e.g. travel costs & distance).
May 23, 2025 at 3:29 PM
3️⃣ intervention: consider shorter duration interventions (<12weeks) and those offered sooner following listing.
4️⃣ sample size: consider up to 30% drop-out.
5️⃣ identify funding or logistical (e.g. virtual) opportunities to address reported barriers to participation (e.g. travel costs & distance).
4️⃣ sample size: consider up to 30% drop-out.
5️⃣ identify funding or logistical (e.g. virtual) opportunities to address reported barriers to participation (e.g. travel costs & distance).
7. Many lessons learned:
1️⃣ logistics: consider challenges & solutions with multi-centre studies (e.g., how to integrate different clinical processes & care across centres).
2️⃣ eligibility: including an upper limit for the length of time since the patient has been listed for HTx
1️⃣ logistics: consider challenges & solutions with multi-centre studies (e.g., how to integrate different clinical processes & care across centres).
2️⃣ eligibility: including an upper limit for the length of time since the patient has been listed for HTx
May 23, 2025 at 3:29 PM
7. Many lessons learned:
1️⃣ logistics: consider challenges & solutions with multi-centre studies (e.g., how to integrate different clinical processes & care across centres).
2️⃣ eligibility: including an upper limit for the length of time since the patient has been listed for HTx
1️⃣ logistics: consider challenges & solutions with multi-centre studies (e.g., how to integrate different clinical processes & care across centres).
2️⃣ eligibility: including an upper limit for the length of time since the patient has been listed for HTx
6. 👟 n=2 patients in PREHAB: HIIT was safe as evidenced by no exercise-related adverse events and patients were able to sustain increases in mean peak power output (PPO) and heart rate (HR) from the first to last exercise bouts (see Figure).
May 23, 2025 at 3:29 PM
6. 👟 n=2 patients in PREHAB: HIIT was safe as evidenced by no exercise-related adverse events and patients were able to sustain increases in mean peak power output (PPO) and heart rate (HR) from the first to last exercise bouts (see Figure).
5. 🔎 Why so few patients?! Being transplanted, medication and device contraindications, trial commitment, transportation barriers, and HIIT not recommended by medical professionals (see detailed CONSORT).
May 23, 2025 at 3:29 PM
5. 🔎 Why so few patients?! Being transplanted, medication and device contraindications, trial commitment, transportation barriers, and HIIT not recommended by medical professionals (see detailed CONSORT).
4. 📅 Trial recruitment began in October 2018 and closed, due to the COVID-19 pandemic, in October 2020. Of the 84 patients screened, 17 were eligible and consented to participate; 2 patients were randomized to each intervention group.
May 23, 2025 at 3:29 PM
4. 📅 Trial recruitment began in October 2018 and closed, due to the COVID-19 pandemic, in October 2020. Of the 84 patients screened, 17 were eligible and consented to participate; 2 patients were randomized to each intervention group.
3. 🏥 Study design: A multi-centre RCT with a target sample size of 60: n=30 > HIIT, n=30 > usual care (as per Canadian Cardiovascular Society guidelines).
May 23, 2025 at 3:29 PM
3. 🏥 Study design: A multi-centre RCT with a target sample size of 60: n=30 > HIIT, n=30 > usual care (as per Canadian Cardiovascular Society guidelines).
2. 🥅 Main goal of trial: We evaluated the impact of a 12-week program of PREHAB (i.e., high-intensity interval training [HIIT], stress management class, and nutritional workshop) compared with usual care in patients with advanced HF awaiting heart transplantation (HTx) on functional capacity.
May 23, 2025 at 3:29 PM
2. 🥅 Main goal of trial: We evaluated the impact of a 12-week program of PREHAB (i.e., high-intensity interval training [HIIT], stress management class, and nutritional workshop) compared with usual care in patients with advanced HF awaiting heart transplantation (HTx) on functional capacity.
1. A 🏔️ during peer review was 📣 why failures are important to publish:
Our response: publication of ➖ clinical trial data is critical (to reduce publication bias & research waste, inform future trial designs, & adherence to ethical reporting for patients who participated in the research).
Our response: publication of ➖ clinical trial data is critical (to reduce publication bias & research waste, inform future trial designs, & adherence to ethical reporting for patients who participated in the research).
May 23, 2025 at 3:29 PM
1. A 🏔️ during peer review was 📣 why failures are important to publish:
Our response: publication of ➖ clinical trial data is critical (to reduce publication bias & research waste, inform future trial designs, & adherence to ethical reporting for patients who participated in the research).
Our response: publication of ➖ clinical trial data is critical (to reduce publication bias & research waste, inform future trial designs, & adherence to ethical reporting for patients who participated in the research).
How can others help this weekend? Door knocking?
April 24, 2025 at 12:40 AM
How can others help this weekend? Door knocking?