These 18-hybrid steroids aren’t particularly biologically active or clinically used, but they are important because they’re well established to be elevated in overt PA and help solidify the argument that what we’re seeing in normotensives actually *is* PA. #NephJC

This is a deep physiologic phenotyping study, more than a clinical one- so people who participated are normotensive volunteers, interested in understanding hypertension risk. #NephJC

Looking to understand pathogenesis of PA, and we know that underlying histopathology of bilateral PA tends to increase with age #NephJC