Julian Echave
@jechave.bsky.social
Interests: molecular evolution, philosophy, poetry, zen.
Reposted by Julian Echave
“De novo design of allosterically switchable protein assemblies” 🧪🧶🧬
Complex assemblies that associate, dissociate, and undergo conformational changes upon introduction of external stimuli
www.biorxiv.org/content/10.1...
Complex assemblies that associate, dissociate, and undergo conformational changes upon introduction of external stimuli
www.biorxiv.org/content/10.1...
November 3, 2023 at 6:04 AM
“De novo design of allosterically switchable protein assemblies” 🧪🧶🧬
Complex assemblies that associate, dissociate, and undergo conformational changes upon introduction of external stimuli
www.biorxiv.org/content/10.1...
Complex assemblies that associate, dissociate, and undergo conformational changes upon introduction of external stimuli
www.biorxiv.org/content/10.1...
Reposted by Julian Echave
“Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling” 🧪🧶🧬
Engineering a Kemp eliminase w/ 250-fold increase in enzymatic activity using an experimental structural ensemble and molecular dynamics-based filtering
www.biorxiv.org/content/10.1...
Engineering a Kemp eliminase w/ 250-fold increase in enzymatic activity using an experimental structural ensemble and molecular dynamics-based filtering
www.biorxiv.org/content/10.1...
November 3, 2023 at 6:04 AM
“Design of efficient artificial enzymes using crystallographically-enhanced conformational sampling” 🧪🧶🧬
Engineering a Kemp eliminase w/ 250-fold increase in enzymatic activity using an experimental structural ensemble and molecular dynamics-based filtering
www.biorxiv.org/content/10.1...
Engineering a Kemp eliminase w/ 250-fold increase in enzymatic activity using an experimental structural ensemble and molecular dynamics-based filtering
www.biorxiv.org/content/10.1...