jcisar.bsky.social
@jcisar.bsky.social
Individual models for preclinical ADME parameters such as clearance, volume of distribution, and oral bioavailability are valuable, but what really matters is the overall effect in vivo and how it could translate to humans.
pubs.acs.org/doi/10.1021/... I am happy to share our efforts in validating an early human dose prediction method that can be used at the point of design.
Toward Dose Prediction at Point of Design
Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis a...
pubs.acs.org
December 13, 2024 at 2:30 PM
Individual models for preclinical ADME parameters such as clearance, volume of distribution, and oral bioavailability are valuable, but what really matters is the overall effect in vivo and how it could translate to humans.
pubs.acs.org/doi/10.1021/... I am happy to share our efforts in validating an early human dose prediction method that can be used at the point of design.
Toward Dose Prediction at Point of Design
Human dose prediction (HDP) is a useful tool for compound optimization in preclinical drug discovery. We describe here our exclusively in silico HDP strategy to triage compound designs for synthesis a...
pubs.acs.org
December 13, 2024 at 2:29 PM
pubs.acs.org/doi/10.1021/... I am happy to share our efforts in validating an early human dose prediction method that can be used at the point of design.