LAB72
@jcarbal.bsky.social
We propose that nucleolar splitting behaves as a mesoscale mechanical readout of meiotic chromosome dynamics, mainly reporting homolog engagement and telomere-led movements rather than absolute DSB load.
Full preprint: (3/3)
www.biorxiv.org/content/10.1...
Full preprint: (3/3)
www.biorxiv.org/content/10.1...
Nucleolar Cdc14 Splitting Reflects Recombination Context and Meiotic Chromosome Dynamics
Chromosome dynamics, recombination, and nucleolar organization intersect during meiotic prophase I, yet how recombination context influences nucleolar architecture remains unclear. We analyzed the nuc...
www.biorxiv.org
December 2, 2025 at 9:36 AM
We propose that nucleolar splitting behaves as a mesoscale mechanical readout of meiotic chromosome dynamics, mainly reporting homolog engagement and telomere-led movements rather than absolute DSB load.
Full preprint: (3/3)
www.biorxiv.org/content/10.1...
Full preprint: (3/3)
www.biorxiv.org/content/10.1...
Splitting is rare and mostly early in our recombination-competent prophase reference (ndt80Δ), but frequent and persistent in recombination-defective (dmc1Δ) and DSB-free settings (spo11-y135f). The pattern does not match Hop1-P–based recombination checkpoint readouts. (2/3)
December 2, 2025 at 9:36 AM
Splitting is rare and mostly early in our recombination-competent prophase reference (ndt80Δ), but frequent and persistent in recombination-defective (dmc1Δ) and DSB-free settings (spo11-y135f). The pattern does not match Hop1-P–based recombination checkpoint readouts. (2/3)