Joel Boerckel
@jboerckel.bsky.social
Assc Prof @pennmedicine.bsky.social.
Co-Director, McKay Orthopaedic Research Labs.
Mechanobiology of development & regeneration.
Prov. 25:2. 🦛
Philadelphia, PA
Co-Director, McKay Orthopaedic Research Labs.
Mechanobiology of development & regeneration.
Prov. 25:2. 🦛
Philadelphia, PA
Out latest preprint, from @cpane94.bsky.social in the lab, is out today!
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
June 19, 2025 at 1:01 AM
Out latest preprint, from @cpane94.bsky.social in the lab, is out today!
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
Maternal exercise rescues fetal akinesia-impaired joint and bone development.
www.biorxiv.org/content/10.1...
So excited for this one - a wonderful collab with Niamh Nowlan, supported by the US-Ireland Partnership Programme ❤️
Proud to see @cpane94.bsky.social giving an @asbmr.bsky.social Member Spotlight Webinar next week (Thursday the 12th)!
He'll be talking about his latest work: "Maternal exercise rescues fetal akinesia-impaired joint and bone development"
Register here: d5jjrf04.na1.hubspotlinks.com/Ctc/5I+113/d...
He'll be talking about his latest work: "Maternal exercise rescues fetal akinesia-impaired joint and bone development"
Register here: d5jjrf04.na1.hubspotlinks.com/Ctc/5I+113/d...
June 4, 2025 at 2:35 PM
Proud to see @cpane94.bsky.social giving an @asbmr.bsky.social Member Spotlight Webinar next week (Thursday the 12th)!
He'll be talking about his latest work: "Maternal exercise rescues fetal akinesia-impaired joint and bone development"
Register here: d5jjrf04.na1.hubspotlinks.com/Ctc/5I+113/d...
He'll be talking about his latest work: "Maternal exercise rescues fetal akinesia-impaired joint and bone development"
Register here: d5jjrf04.na1.hubspotlinks.com/Ctc/5I+113/d...
Our paper, led by Chris Panebianco (@cpane94.bsky.social) is out today at Developmental Dynamics!
"Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod."
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
"Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod."
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
May 14, 2025 at 3:32 PM
Our paper, led by Chris Panebianco (@cpane94.bsky.social) is out today at Developmental Dynamics!
"Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod."
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
"Dynamics of postnatal bone development and epiphyseal synostosis in the caprine autopod."
anatomypubs.onlinelibrary.wiley.com/doi/10.1002/...
Nothing calms like going to the library and bringing home a good poet.
May 6, 2025 at 6:39 PM
Nothing calms like going to the library and bringing home a good poet.
Facilities, overhead.
May 3, 2025 at 5:54 PM
Facilities, overhead.
In a vascularized bone-on-a-chip system, we found that mechanical loading modulated angiogenesis in a manner dependent on load timing and CYR61 treatment.
These data extend our prior findings on mechanical regulation of CYR61 expression during angiogenesis: www.science.org/doi/10.1126/...
These data extend our prior findings on mechanical regulation of CYR61 expression during angiogenesis: www.science.org/doi/10.1126/...
April 24, 2025 at 3:15 AM
In a vascularized bone-on-a-chip system, we found that mechanical loading modulated angiogenesis in a manner dependent on load timing and CYR61 treatment.
These data extend our prior findings on mechanical regulation of CYR61 expression during angiogenesis: www.science.org/doi/10.1126/...
These data extend our prior findings on mechanical regulation of CYR61 expression during angiogenesis: www.science.org/doi/10.1126/...
While CYR61 delivery in this system did not significantly affect bone or cartilage formation, it robustly stimulated angiogenesis.
April 24, 2025 at 3:15 AM
While CYR61 delivery in this system did not significantly affect bone or cartilage formation, it robustly stimulated angiogenesis.
Here, @amilangscience.bsky.social studied the effects of mechanical loading on bone fracture repair.
Identifying the YAP/TAZ target gene, CYR61 as a potential therapeutic fracture repair, she delivered rCYR61 to bone fractures in hematoma-mimetic hydrogels.
Identifying the YAP/TAZ target gene, CYR61 as a potential therapeutic fracture repair, she delivered rCYR61 to bone fractures in hematoma-mimetic hydrogels.
April 24, 2025 at 3:15 AM
Here, @amilangscience.bsky.social studied the effects of mechanical loading on bone fracture repair.
Identifying the YAP/TAZ target gene, CYR61 as a potential therapeutic fracture repair, she delivered rCYR61 to bone fractures in hematoma-mimetic hydrogels.
Identifying the YAP/TAZ target gene, CYR61 as a potential therapeutic fracture repair, she delivered rCYR61 to bone fractures in hematoma-mimetic hydrogels.
Deleting every “superfluous that” makes your writing less clear.
April 12, 2025 at 10:57 PM
Deleting every “superfluous that” makes your writing less clear.
Taught my kids how to play Euchre tonight.
This is a new level of parenting joy I hadn’t anticipated when they were small.
This is a new level of parenting joy I hadn’t anticipated when they were small.
February 24, 2025 at 12:22 AM
Taught my kids how to play Euchre tonight.
This is a new level of parenting joy I hadn’t anticipated when they were small.
This is a new level of parenting joy I hadn’t anticipated when they were small.
Sean and I rode our bikes down to the Eagles parade today.
Best part was the Kelly Dr. road closure.
Best part was the Kelly Dr. road closure.
February 14, 2025 at 10:21 PM
Sean and I rode our bikes down to the Eagles parade today.
Best part was the Kelly Dr. road closure.
Best part was the Kelly Dr. road closure.
Returning home rejuvenated by time w so many dear friends at #ORS2025
Also so proud and thankful for my group.
Special congrats to @cpane94.bsky.social on winning the NIRA, @amilangscience.bsky.social on @isfrfractures.bsky.social🥇Podium Award and @eseidlscience.bsky.social on Tendon 3MT Award 🙌
Also so proud and thankful for my group.
Special congrats to @cpane94.bsky.social on winning the NIRA, @amilangscience.bsky.social on @isfrfractures.bsky.social🥇Podium Award and @eseidlscience.bsky.social on Tendon 3MT Award 🙌
February 12, 2025 at 3:12 AM
Returning home rejuvenated by time w so many dear friends at #ORS2025
Also so proud and thankful for my group.
Special congrats to @cpane94.bsky.social on winning the NIRA, @amilangscience.bsky.social on @isfrfractures.bsky.social🥇Podium Award and @eseidlscience.bsky.social on Tendon 3MT Award 🙌
Also so proud and thankful for my group.
Special congrats to @cpane94.bsky.social on winning the NIRA, @amilangscience.bsky.social on @isfrfractures.bsky.social🥇Podium Award and @eseidlscience.bsky.social on Tendon 3MT Award 🙌
Excited for #ORS2025 and super proud of this group who will be presenting their work!
🙌🏻 @madhura0327.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social @amilangscience.bsky.social @cpane94.bsky.social
ht @cpane94.bsky.social for the slide!
🙌🏻 @madhura0327.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social @amilangscience.bsky.social @cpane94.bsky.social
ht @cpane94.bsky.social for the slide!
February 6, 2025 at 6:29 PM
Excited for #ORS2025 and super proud of this group who will be presenting their work!
🙌🏻 @madhura0327.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social @amilangscience.bsky.social @cpane94.bsky.social
ht @cpane94.bsky.social for the slide!
🙌🏻 @madhura0327.bsky.social @gkotsaris90.bsky.social @eseidlscience.bsky.social @amilangscience.bsky.social @cpane94.bsky.social
ht @cpane94.bsky.social for the slide!
90 minutes of continuum mechanics expressed in chalk length change.
Find the deformation gradient.
Find the deformation gradient.
February 6, 2025 at 3:13 PM
90 minutes of continuum mechanics expressed in chalk length change.
Find the deformation gradient.
Find the deformation gradient.
If I ever had to pick a walk-on song, it would be The Genetic Method.
RIP Garth Hudson ❤️
RIP Garth Hudson ❤️
January 28, 2025 at 3:00 AM
If I ever had to pick a walk-on song, it would be The Genetic Method.
RIP Garth Hudson ❤️
RIP Garth Hudson ❤️
I like to think they have Snidely Whiplash vibes
January 26, 2025 at 6:20 PM
I like to think they have Snidely Whiplash vibes
TFW you receive something you can tell wasn’t GPT-generated
January 22, 2025 at 8:50 PM
TFW you receive something you can tell wasn’t GPT-generated
So wonderful to have @joyywu.bsky.social as PCMD Visting Professor! Thanks for the great talk, Joy!
January 15, 2025 at 10:36 AM
So wonderful to have @joyywu.bsky.social as PCMD Visting Professor! Thanks for the great talk, Joy!
Remarkably, making the fracture site hypoxic promoted angiogenesis and increased bone formation.
January 15, 2025 at 4:23 AM
Remarkably, making the fracture site hypoxic promoted angiogenesis and increased bone formation.
Annemarie then did a cool experiment: she treated fractures with a CD71-blocking antibody, which prevents iron import.
CD71 blockade arrested heme synthesis and made the fracture site hypoxic!
CD71 blockade arrested heme synthesis and made the fracture site hypoxic!
January 15, 2025 at 4:23 AM
Annemarie then did a cool experiment: she treated fractures with a CD71-blocking antibody, which prevents iron import.
CD71 blockade arrested heme synthesis and made the fracture site hypoxic!
CD71 blockade arrested heme synthesis and made the fracture site hypoxic!
These erythroid progenitor cells express CD71, or Transferrin receptor 1.
Erythroid cells are super iron-hungry, as they begin to make hemoglobin, which uses iron to bind oxygen. Transferrin receptor is the primary iron transporter in these cells.
Erythroid cells are super iron-hungry, as they begin to make hemoglobin, which uses iron to bind oxygen. Transferrin receptor is the primary iron transporter in these cells.
January 15, 2025 at 4:22 AM
These erythroid progenitor cells express CD71, or Transferrin receptor 1.
Erythroid cells are super iron-hungry, as they begin to make hemoglobin, which uses iron to bind oxygen. Transferrin receptor is the primary iron transporter in these cells.
Erythroid cells are super iron-hungry, as they begin to make hemoglobin, which uses iron to bind oxygen. Transferrin receptor is the primary iron transporter in these cells.
We found that fracture activated local erythroid progenitor cells, without a change in serum EPO!
January 15, 2025 at 4:22 AM
We found that fracture activated local erythroid progenitor cells, without a change in serum EPO!
Now, when a bone is fractured, it breaks the bone and ruptures the vessels, but it also breaks the bone marrow. Bone marrow is special because it is the site of erythropoiesis: the production of new red blood cells from stem cells.
January 15, 2025 at 4:21 AM
Now, when a bone is fractured, it breaks the bone and ruptures the vessels, but it also breaks the bone marrow. Bone marrow is special because it is the site of erythropoiesis: the production of new red blood cells from stem cells.
What could cause this high oxygen? Fracture rapidly causes hematoma formation, which arrests bleeding and cuts off the supply of new erythrocytes.
So, we took a single cell approach to identify the cell populations at the fracture site, compared to contralateral bone marrow.
So, we took a single cell approach to identify the cell populations at the fracture site, compared to contralateral bone marrow.
January 15, 2025 at 4:21 AM
What could cause this high oxygen? Fracture rapidly causes hematoma formation, which arrests bleeding and cuts off the supply of new erythrocytes.
So, we took a single cell approach to identify the cell populations at the fracture site, compared to contralateral bone marrow.
So, we took a single cell approach to identify the cell populations at the fracture site, compared to contralateral bone marrow.