@jblalanne.bsky.social
Fruitful teamwork with J. K. Mich and A. C. Hunker at Allen Brain. Huge thanks to other members of @jshendure.bsky.social's lab for absolutely critical assistance, notably C. Huynh and @troymcdiarmid.bsky.social
January 17, 2025 at 3:53 PM
Fruitful teamwork with J. K. Mich and A. C. Hunker at Allen Brain. Huge thanks to other members of @jshendure.bsky.social's lab for absolutely critical assistance, notably C. Huynh and @troymcdiarmid.bsky.social
Why is this important? We think this chimerism is a substantial contributor to the experimental noise typically seen in AAV-MPRA type experiments, as detailed in this fantastic piece from our collaborators: doi.org/10.1101/2025...
This could have implications for other class of experiments as well.
This could have implications for other class of experiments as well.
January 17, 2025 at 3:53 PM
Why is this important? We think this chimerism is a substantial contributor to the experimental noise typically seen in AAV-MPRA type experiments, as detailed in this fantastic piece from our collaborators: doi.org/10.1101/2025...
This could have implications for other class of experiments as well.
This could have implications for other class of experiments as well.
Through some well-controlled paired-barcodes experiments & long-read sequencing, we found that with kb-sized homologous inserts, nearly half of packaged genomes showed evidence of barcode swapping.
January 17, 2025 at 3:53 PM
Through some well-controlled paired-barcodes experiments & long-read sequencing, we found that with kb-sized homologous inserts, nearly half of packaged genomes showed evidence of barcode swapping.