Jan-Matthis Lueckmann
@janmatthis.bsky.social
Research scientist at Google in Zurich
http://research.google/teams/connectomics
PhD from @mackelab.bsky.social
http://research.google/teams/connectomics
PhD from @mackelab.bsky.social
Pinned
ZAPBench
ZAPBench evaluates how well different models can predict the activity of over 70,000 neurons in a novel larval zebrafish dataset.
google-research.github.io
⚡️ Excited to introduce ZAPBench, our #ICLR2025 spotlight: The Zebrafish Activity Prediction Benchmark measures progress in predicting neural activity within an entire vertebrate brain (70k+ neurons!)
Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench
🧠🧪
Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench
🧠🧪
Reposted by Jan-Matthis Lueckmann
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Jaxley: differentiable simulation enables large-scale training of detailed biophysical models of neural dynamics - Nature Methods
Jaxley is a versatile platform for biophysical modeling in neuroscience. It allows efficiently simulating large-scale biophysical models on CPUs, GPUs and TPUs. Model parameters can be optimized with ...
www.nature.com
November 13, 2025 at 1:08 PM
Our work on training biophysical models with Jaxley is now out in @natmethods.nature.com. Led by @deismic.bsky.social, with @philipp.hertie.ai, @ppjgoncalves.bsky.social & @jakhmack.bsky.social et al.
Paper: www.nature.com/articles/s41...
Paper: www.nature.com/articles/s41...
Reposted by Jan-Matthis Lueckmann
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
An ion channel omnimodel for standardized biophysical neuron modelling
Biophysical neuron modeling is an indispensable tool in neuroscience research, with the combination of diverse ion channel kinetics and morphologies being used to explain various single-neuron propert...
www.biorxiv.org
October 6, 2025 at 6:25 PM
“Mapping ion channel function” doi.org/10.7554/eLif... isn’t exactly a citation slayer, but it’s still one of my favourites (& my first independent project). Today we push pt 2, where we trace code origin & unite almost all channel models in a common expression. Boom! www.biorxiv.org/content/10.1...
Reposted by Jan-Matthis Lueckmann
New preprint: SBI with foundation models!
Tired of training or tuning your inference network, or waiting for your simulations to finish? Our method NPE-PF can help: It provides training-free simulation-based inference, achieving competitive performance with orders of magnitude fewer simulations! ⚡️
Tired of training or tuning your inference network, or waiting for your simulations to finish? Our method NPE-PF can help: It provides training-free simulation-based inference, achieving competitive performance with orders of magnitude fewer simulations! ⚡️
July 23, 2025 at 2:28 PM
New preprint: SBI with foundation models!
Tired of training or tuning your inference network, or waiting for your simulations to finish? Our method NPE-PF can help: It provides training-free simulation-based inference, achieving competitive performance with orders of magnitude fewer simulations! ⚡️
Tired of training or tuning your inference network, or waiting for your simulations to finish? Our method NPE-PF can help: It provides training-free simulation-based inference, achieving competitive performance with orders of magnitude fewer simulations! ⚡️
Reposted by Jan-Matthis Lueckmann
Wouldn't it be great if we could not only image large connectomic volumes but also completely reconstruct them? And if a whole mouse brain project didn't cost billions?
With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.
With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.
May 22, 2025 at 11:42 AM
Wouldn't it be great if we could not only image large connectomic volumes but also completely reconstruct them? And if a whole mouse brain project didn't cost billions?
With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.
With the PATHFINDER preprint (www.biorxiv.org/content/10.1...), we preview a future where it doesn't have to.
⚡️ Excited to introduce ZAPBench, our #ICLR2025 spotlight: The Zebrafish Activity Prediction Benchmark measures progress in predicting neural activity within an entire vertebrate brain (70k+ neurons!)
Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench
🧠🧪
Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench
🧠🧪
ZAPBench
ZAPBench evaluates how well different models can predict the activity of over 70,000 neurons in a novel larval zebrafish dataset.
google-research.github.io
March 4, 2025 at 3:22 PM
⚡️ Excited to introduce ZAPBench, our #ICLR2025 spotlight: The Zebrafish Activity Prediction Benchmark measures progress in predicting neural activity within an entire vertebrate brain (70k+ neurons!)
Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench
🧠🧪
Explore interactive visualizations, datasets, code + paper: google-research.github.io/zapbench
🧠🧪
Reposted by Jan-Matthis Lueckmann
If you use the sbi toolbox, help make it better by sharing your feedback!!
🙏 Please help us improve the SBI toolbox! 🙏
In preparation for the upcoming SBI Hackathon, we’re running a user study to learn what you like, what we can improve, and how we can grow.
👉 Please share your thoughts here: forms.gle/foHK7myV2oaK...
Your input will make a big difference—thank you! 🙌
In preparation for the upcoming SBI Hackathon, we’re running a user study to learn what you like, what we can improve, and how we can grow.
👉 Please share your thoughts here: forms.gle/foHK7myV2oaK...
Your input will make a big difference—thank you! 🙌
February 6, 2025 at 8:55 PM
If you use the sbi toolbox, help make it better by sharing your feedback!!