Indeed, we were able to replicate the empirical observations across the across the synthetic aging trajectory, including the decrease in slow wave frequency, increase in variability, and decrease in amplitude.

We swapped out the neural mass model for one capturing the sleep-like dynamics (AdEx), and then followed the properties of the simulated slow waves across the aging trajectory bu decreasing gradually the inter-hemispheric connections in representative young connectomes.

During aging, the slow waves are getting flatter and occur less frequently and with more variability. This was shown on a sample of over 2300 subjects using EEG head band during sleep.

doi.org/10.1101/2023...