Jeff Goldstein
@jagstein.bsky.social
Northwestern, placenta pathology, machine learning, infections in pregnancy, not giving medical advice, available for media
Still life with Zebra Mussels, Chicago
September 24, 2025 at 3:12 PM
Still life with Zebra Mussels, Chicago
8 dug a 🎮-shaped hole at the beach and demanded I show bluesky
July 11, 2025 at 1:25 AM
8 dug a 🎮-shaped hole at the beach and demanded I show bluesky
Geometry diagram in the skies above Chicago
July 3, 2025 at 1:44 PM
Geometry diagram in the skies above Chicago
Mushrooms from Mammoth Cave National Park
March 27, 2025 at 5:53 PM
Mushrooms from Mammoth Cave National Park
Hourly weather with lots of details?
March 5, 2025 at 4:28 PM
Hourly weather with lots of details?
Reviewing a proposal for a colleague yesterday, "don't summon the casual interference police!!" Who are the casual inference police?
February 25, 2025 at 2:46 PM
Reviewing a proposal for a colleague yesterday, "don't summon the casual interference police!!" Who are the casual inference police?
Now rereading: blitzed, the History of drugs and the third Reich.
February 19, 2025 at 1:32 PM
Now rereading: blitzed, the History of drugs and the third Reich.
Two vessel umbilical cord. One artery, one vein (normal 2 arteries). Seen in ~1% of pregnancies, most often an isolated finding, but there may be associated genitourinary abnormalities. #placentapath
February 12, 2025 at 2:23 PM
Two vessel umbilical cord. One artery, one vein (normal 2 arteries). Seen in ~1% of pregnancies, most often an isolated finding, but there may be associated genitourinary abnormalities. #placentapath
From "Would you rather" copyright 2003: would you rather have to use a calculator that makes a mistake once every 50 computations OR do all the calculations by hand?
February 4, 2025 at 11:12 PM
From "Would you rather" copyright 2003: would you rather have to use a calculator that makes a mistake once every 50 computations OR do all the calculations by hand?
I pay attention to the vascular smooth muscle nuclei. This vessel was from the same section and shows intact nuclei, supporting that the thrombus above is pre-mortem.
January 29, 2025 at 2:49 PM
I pay attention to the vascular smooth muscle nuclei. This vessel was from the same section and shows intact nuclei, supporting that the thrombus above is pre-mortem.
What am I looking for in the umbilical cord? Adherent thrombus. Loss of endothelium, some layering of fibrin. This finding is sufficient to explain a demise.
January 29, 2025 at 2:49 PM
What am I looking for in the umbilical cord? Adherent thrombus. Loss of endothelium, some layering of fibrin. This finding is sufficient to explain a demise.
Compare & contrast with hemosiderin, which is chunkier and more reliably brown. Iron stain can help you, but not all heme breakdown products will stain(!)
January 29, 2025 at 1:22 AM
Compare & contrast with hemosiderin, which is chunkier and more reliably brown. Iron stain can help you, but not all heme breakdown products will stain(!)
What am I looking for in #placenta membranes: meconium -laden macrophages. Orangey / brownish foamy material in macrophages. The foaminess is more reliable than the color (poop is different colors(!))
January 29, 2025 at 1:22 AM
What am I looking for in #placenta membranes: meconium -laden macrophages. Orangey / brownish foamy material in macrophages. The foaminess is more reliable than the color (poop is different colors(!))
What am I looking for in the placental membranes? Chronic deciduitis with plasma cells (cdpc). Usually lymphocytic background. For me, you must have plasma cells - some places will call it if there are "enough" lymphs.
January 27, 2025 at 9:44 PM
What am I looking for in the placental membranes? Chronic deciduitis with plasma cells (cdpc). Usually lymphocytic background. For me, you must have plasma cells - some places will call it if there are "enough" lymphs.
MIR stage 3 - chorioamnionitis with amnion necrosis. Can still have line amnion cells... Criteria are thickened basement membrane or neutrophil karyorrhexis. Highest risk of neonatal sepsis.
January 23, 2025 at 6:05 PM
MIR stage 3 - chorioamnionitis with amnion necrosis. Can still have line amnion cells... Criteria are thickened basement membrane or neutrophil karyorrhexis. Highest risk of neonatal sepsis.
Maternal inflammatory response stage 2, acute chorioamnionitis - more than a few neutrophils in the fibrous chorion and amnion. I need to see subchorio as well.
January 23, 2025 at 6:05 PM
Maternal inflammatory response stage 2, acute chorioamnionitis - more than a few neutrophils in the fibrous chorion and amnion. I need to see subchorio as well.
Maternal inflammatory response in #placenta membranes. Stage 1, subchorionitis. At least a few neutrophils lining up below the fibrous chorion
January 23, 2025 at 6:05 PM
Maternal inflammatory response in #placenta membranes. Stage 1, subchorionitis. At least a few neutrophils lining up below the fibrous chorion
But pd.datetime >>> dt
January 19, 2025 at 4:02 PM
But pd.datetime >>> dt
Placental Pathology in fetal demise: cytomegalovirus (CMV). Infectious villitis. Plasma cells and calcifications significantly more frequent than in VUE. May see inclusions. CMV IHC is diagnostic.
January 16, 2025 at 2:34 PM
Placental Pathology in fetal demise: cytomegalovirus (CMV). Infectious villitis. Plasma cells and calcifications significantly more frequent than in VUE. May see inclusions. CMV IHC is diagnostic.
Placental Pathology in stillbirth - retro placental hemorrhage / hematoma, suggestive of abruption. Micro shows nasal plate disruption, fibrin, and villous infarction
January 10, 2025 at 2:28 PM
Placental Pathology in stillbirth - retro placental hemorrhage / hematoma, suggestive of abruption. Micro shows nasal plate disruption, fibrin, and villous infarction
Placental Pathology in fetal demise: immune hydrops. Massively elevated nucleated red blood cells in the fetal circulation. Rare erythroblasts were noted.
January 8, 2025 at 2:40 PM
Placental Pathology in fetal demise: immune hydrops. Massively elevated nucleated red blood cells in the fetal circulation. Rare erythroblasts were noted.
