Jack C. Lennon
@jackclennon.bsky.social
Forensic Neuropsychiatry | Principal Medical Writer
Using neuroimaging to help vacate the death penalty, one human at a time.
Using neuroimaging to help vacate the death penalty, one human at a time.
Reposted by Jack C. Lennon
RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS https://www.biorxiv.org/content/10.1101/2024.12.02.626340v1
RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS https://www.biorxiv.org/content/10.1101/2024.12.02.626340v1
Recent research has demonstrated significant aberrant activation of the innate immune system in ALS
www.biorxiv.org
December 3, 2024 at 2:17 AM
RIG-I mediated neuron-specific IFN type 1 signaling in FUS-ALS induces neurodegeneration and offers new biomarker-driven individualized treatment options for (FUS-)ALS https://www.biorxiv.org/content/10.1101/2024.12.02.626340v1
Reposted by Jack C. Lennon
I truly wouldn’t care if a man dressed like the king of England was in the urinal next to me. I get that for extremely online rightwingers, a trip to a public bathroom might be the most memorable moment of the day, but the rest of us truly do not give a shit who is peeing nearby.
November 19, 2024 at 6:55 PM
I truly wouldn’t care if a man dressed like the king of England was in the urinal next to me. I get that for extremely online rightwingers, a trip to a public bathroom might be the most memorable moment of the day, but the rest of us truly do not give a shit who is peeing nearby.
Reposted by Jack C. Lennon
Would love to hear from a Republican worried about food or housing costs how exactly deporting 10 million people who grow and pick our food and build our houses is going to lower food or housing costs.
November 19, 2024 at 11:27 PM
Would love to hear from a Republican worried about food or housing costs how exactly deporting 10 million people who grow and pick our food and build our houses is going to lower food or housing costs.
Malpetti and colleagues report that inflammation in frontal areas is associated with more rapid cognitive decline in people with a clinical diagnosis of FTD, providing complementary info to grey matter volume. tinyurl.com/nhhftk9f
Microglial activation in the frontal cortex predicts cognitive decline in frontotemporal dementia
Malpetti et al. report that inflammation in frontal regions is associated with faster cognitive decline in people with a clinical diagnosis of frontotempor
tinyurl.com
November 19, 2024 at 11:36 PM
Malpetti and colleagues report that inflammation in frontal areas is associated with more rapid cognitive decline in people with a clinical diagnosis of FTD, providing complementary info to grey matter volume. tinyurl.com/nhhftk9f
A new FSLeyes is out, with a range of small tweaks, improvements to the plugin framework, and some new lightbox features including overlap. Details at open.win.ox.ac.uk/pages/fsl/fsle…, install/update instructions at fsl.fmrib.ox.ac.uk/fsl/fslwiki/FS
November 19, 2024 at 11:35 PM
A new FSLeyes is out, with a range of small tweaks, improvements to the plugin framework, and some new lightbox features including overlap. Details at open.win.ox.ac.uk/pages/fsl/fsle…, install/update instructions at fsl.fmrib.ox.ac.uk/fsl/fslwiki/FS
From Maps to Multi-dimensional Network Mechanisms of Mental Disorders: Neuron www.cell.com/neuron/fullt...
From Maps to Multi-dimensional Network Mechanisms of Mental Disorders
Braun and colleagues describe a set of new computational tools from multi-dimensional
network neuroscience that allow for mechanistic inquiry of neuropsychiatric disorders,
and they outline strategies...
www.cell.com
November 19, 2024 at 11:34 PM
From Maps to Multi-dimensional Network Mechanisms of Mental Disorders: Neuron www.cell.com/neuron/fullt...
Take a look at ComplexUpset, a new R package for generating great UpSet plots directly with ggplot2.
November 19, 2024 at 11:34 PM
Take a look at ComplexUpset, a new R package for generating great UpSet plots directly with ggplot2.
November 19, 2024 at 3:13 AM
In adults without cognitive impairment and with low brain Aβ levels, a blood test combining Aβ42/40 and p-tau217 better predicted longitudinal changes in brain Aβ load than individual biomarkers.
ja.ma/4dM62xd
ja.ma/4dM62xd
p-Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation
This cohort study investigates the utility of plasma markers phosphorylated tau 217 (p-tau217) and β-amyloid 42/40 (Aβ42/40) to predict development of Alzheimer disease–related Aβ pathology in cogniti...
ja.ma
November 18, 2024 at 2:24 AM
In adults without cognitive impairment and with low brain Aβ levels, a blood test combining Aβ42/40 and p-tau217 better predicted longitudinal changes in brain Aβ load than individual biomarkers.
ja.ma/4dM62xd
ja.ma/4dM62xd
Hommersom et al. show in a human neuronal model that CACNA1A haploinsufficiency leads to synaptic deficits but increased intrinsic excitability, resulting in a variable phenotype ranging from ataxia to neurodevelopmental disorders. tinyurl.com/455bvtp3
CACNA1A haploinsufficiency leads to reduced synaptic function and increased intrinsic excitability
CACNA1A haploinsufficiency leads to a clinically variable phenotype ranging from ataxia to neurodevelopmental syndromes. Hommersom et al. investigate the u
tinyurl.com
November 18, 2024 at 2:18 AM
Hommersom et al. show in a human neuronal model that CACNA1A haploinsufficiency leads to synaptic deficits but increased intrinsic excitability, resulting in a variable phenotype ranging from ataxia to neurodevelopmental disorders. tinyurl.com/455bvtp3
Lisi & colleagues describe how incorporation of clinically relevant blood-based biomarkers into preclinical TBI research can facilitate the translation of findings into effective treatments, ultimately improving patient outcomes. tinyurl.com/ys7deuk4
Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury
Lisi et al. explore how incorporating clinically relevant blood-based biomarkers into preclinical traumatic brain injury research can facilitate the transl
tinyurl.com
November 18, 2024 at 1:58 AM
Lisi & colleagues describe how incorporation of clinically relevant blood-based biomarkers into preclinical TBI research can facilitate the translation of findings into effective treatments, ultimately improving patient outcomes. tinyurl.com/ys7deuk4