@iwangtoknow.bsky.social
Reposted
Happy to introduce SegMantX. Analyzing #plasmid we find that most duplications are MGE-driven. Additional use cases include detection of DNA transfer between replicons and examination of plasmid sequence similarity. Try it out! doi.org/10.1093/molb...
SegMantX: a novel tool for detecting DNA duplications uncovers prevalent duplications in plasmids
Abstract. Segmental duplications play an important role in genome evolution via their contribution to copy-number variation, gene-family diversification an
doi.org
October 8, 2025 at 9:16 AM
Happy to introduce SegMantX. Analyzing #plasmid we find that most duplications are MGE-driven. Additional use cases include detection of DNA transfer between replicons and examination of plasmid sequence similarity. Try it out! doi.org/10.1093/molb...
Reposted
Happy to finally share this! Read here about the best strategy the the persistence of low-copy plasmids. @mariosanter.bsky.social @iwangtoknow.bsky.social doi.org/10.1038/s414...
The combination of active partitioning and toxin-antitoxin systems is most advantageous for low-copy plasmid fitness - Nature Communications
Effe et al. evaluate how specific plasmid traits influence plasmid fitness; they provide mechanistic insight into the persistence of large conjugative plasmids, including those that disseminate antibi...
doi.org
August 3, 2025 at 10:46 AM
Happy to finally share this! Read here about the best strategy the the persistence of low-copy plasmids. @mariosanter.bsky.social @iwangtoknow.bsky.social doi.org/10.1038/s414...
Reposted
Lucaprot leverages AI to discover highly-divergent RNA-dependent RNA polymerase sequences, completely revolutionizing the field of RNA Virus discovery! We are ecstatic to have Xin Hou (@xinhou.bsky.social) as one of our invited speakers at the #RdRpSummit2025!
May 9, 2025 at 2:59 PM
Lucaprot leverages AI to discover highly-divergent RNA-dependent RNA polymerase sequences, completely revolutionizing the field of RNA Virus discovery! We are ecstatic to have Xin Hou (@xinhou.bsky.social) as one of our invited speakers at the #RdRpSummit2025!
Reposted
Imagine that you are a low-copy extra-chromosomal genetic elements invading a host cell. What’s your best strategy to survive? Check our new study of prokaryotic #plasmid for the answer! www.biorxiv.org/content/10.1... led by Johannes Effe with @iwangtoknow.bsky.social and more! (not on bsky)
Persistence of large conjugative plasmids relies on the combination of active partitioning and addiction mechanisms
Extrachromosomal and mobile genetic elements, including transposable elements, plasmids, and accessory chromosomes, are found across all domains of life. The replication and segregation of elements in...
www.biorxiv.org
February 12, 2025 at 5:10 PM
Imagine that you are a low-copy extra-chromosomal genetic elements invading a host cell. What’s your best strategy to survive? Check our new study of prokaryotic #plasmid for the answer! www.biorxiv.org/content/10.1... led by Johannes Effe with @iwangtoknow.bsky.social and more! (not on bsky)