Ishitani Lab
@ishitani-lab.bsky.social
exploring cell-cell/organ-organ communication systems ensuring developmental robustness and disease/ageing prevention, using small fish models.
小魚をヒトモデルに、健康な発育・成長を支え、健康寿命を伸ばすメカニズムの探索・解析を行います！やってる人も聞く人もどっちも楽しくなるようなサイエンスを目指してます！！！
小魚をヒトモデルに、健康な発育・成長を支え、健康寿命を伸ばすメカニズムの探索・解析を行います！やってる人も聞く人もどっちも楽しくなるようなサイエンスを目指してます！！！
VERY HAPPY to share our new paper in Aging Cell (doi.org/10.1111/acel...). We discovered the unexpected roles of ER stress in youthful skin maintenance, using ultra-short lived killifish and spacial transcriptomics PIC. #aging #killifish
ER Stress Ire1‐Xbp1s Pathway Maintains Youthful Epidermal Basal Layer Through the Regulation of Cell Proliferation
In young epidermal basal layer, the Ire1-Xbp1s endoplasmic reticulum (ER) stress-response pathway maintains cell proliferation by activating the cell cycle regulator Vcp, whereas the age-dependent de....
doi.org
October 13, 2025 at 6:51 AM
VERY HAPPY to share our new paper in Aging Cell (doi.org/10.1111/acel...). We discovered the unexpected roles of ER stress in youthful skin maintenance, using ultra-short lived killifish and spacial transcriptomics PIC. #aging #killifish
Excited to share our latest review article published in Seminars in Cell & Developmental Biology "Mechanical force-driven cell competition ensures robust morphogen gradient formation"
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
April 13, 2025 at 3:10 AM
Excited to share our latest review article published in Seminars in Cell & Developmental Biology "Mechanical force-driven cell competition ensures robust morphogen gradient formation"
authors.elsevier.com/sd/article/S...
authors.elsevier.com/sd/article/S...
Our recent paper featured in a Nature Communications Editors’ Highlights (the 50 best papers recently published)!!
www.nature.com/collections/...
www.nature.com/collections/...
EXCITED to share our new paper in Nat Commun @natureportfolio.bsky.social "Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development”, identifying a potential marker of cell competition. #zebrafish #cellcompetition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development - Nature Communications
Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell competiti...
www.nature.com
January 23, 2025 at 1:20 AM
Our recent paper featured in a Nature Communications Editors’ Highlights (the 50 best papers recently published)!!
www.nature.com/collections/...
www.nature.com/collections/...
The meeting report of the international zebrafish conference (IZFC2024) "Swimming Into Future Breakthroughs From Kyoto, Japan:"has been published in Genes to Cells.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Swimming Into Future Breakthroughs From Kyoto, Japan: Report of the 18th International Zebrafish Conference (IZFC2024)
IZFC2024, held from August 17 to 21, 2024, in Kyoto, Japan, attracted 641 researchers from 38 countries. The conference fostered investigation, innovation, and collaboration in zebrafish research, in...
onlinelibrary.wiley.com
January 8, 2025 at 3:16 AM
The meeting report of the international zebrafish conference (IZFC2024) "Swimming Into Future Breakthroughs From Kyoto, Japan:"has been published in Genes to Cells.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Ishitani Lab
異常細胞除く「細胞競合」、因子特定で可視化 大阪大 - 日本経済新聞 www.nikkei.com/article/DGXZ...
異常細胞除く「細胞競合」、因子特定で可視化 大阪大 - 日本経済新聞
大阪大学の石谷太教授らは、正常な細胞が異常な細胞を排除する「細胞競合」に関わる遺伝子を特定した。この遺伝子を活用すれば、除去される異常細胞を可視化できる。細胞競合が起きる場所や時期を調べられ、病気の解明や医薬品の開発などにつながる可能性がある。細胞は分裂をくり返して増殖し、臓器や組織を形づくる。人間や動物の体には増殖の過程でできた異常な細胞を除去する細胞競合という現象がある。この働きが低下する
www.nikkei.com
December 29, 2024 at 12:56 AM
異常細胞除く「細胞競合」、因子特定で可視化 大阪大 - 日本経済新聞 www.nikkei.com/article/DGXZ...
EXCITED to share our new paper in Nat Commun @natureportfolio.bsky.social "Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development”, identifying a potential marker of cell competition. #zebrafish #cellcompetition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development - Nature Communications
Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell competiti...
www.nature.com
December 17, 2024 at 12:28 PM
EXCITED to share our new paper in Nat Commun @natureportfolio.bsky.social "Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development”, identifying a potential marker of cell competition. #zebrafish #cellcompetition
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Ishitani Lab
The longevity factor Foxo3 mediates “unfit” cell elimination to ensure both precise development and cancer prevention
Open Access
www.nature.com/articles/s41...
Open Access
www.nature.com/articles/s41...
Foxo3-mediated physiological cell competition ensures robust tissue patterning throughout vertebrate development - Nature Communications
Physiological roles of cell competition in vertebrates and the universal mechanisms regulating diverse cell competition are unknown. Here, authors show that Foxo3-mediated physiological cell competiti...
www.nature.com
December 17, 2024 at 11:53 AM
The longevity factor Foxo3 mediates “unfit” cell elimination to ensure both precise development and cancer prevention
Open Access
www.nature.com/articles/s41...
Open Access
www.nature.com/articles/s41...