Ehud Isacoff Lab
@isacofflab.bsky.social
#Neuroscience #UCBerkeley
Behavioral resilience via dynamic circuit firing homeostasis | PNAS www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
www.pnas.org
May 8, 2025 at 10:44 PM
Behavioral resilience via dynamic circuit firing homeostasis | PNAS www.pnas.org/doi/10.1073/...
Reposted by Ehud Isacoff Lab
East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu recently paid a visit to the University of California, Berkeley’s Innovative Genomics Institute to hear about the importance of NIH-funded basic research. news.berkeley.edu/2025/02/24/d...
During campus visit, U.S. representatives vow to fight freeze on federal research funding - Berkeley News
East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu visited the Innovative Genomics Institute for a tour and briefing
news.berkeley.edu
February 25, 2025 at 9:34 PM
East Bay Rep. Lateefah Simon and Los Angeles Rep. Ted Lieu recently paid a visit to the University of California, Berkeley’s Innovative Genomics Institute to hear about the importance of NIH-funded basic research. news.berkeley.edu/2025/02/24/d...
Reposted by Ehud Isacoff Lab
Our THIK study of the THIK K2P is out showing a novel feature that affects function (flow restrictor) and a PUFA modulation site. Congratulations to my team. 🥳 See also work by @profkalium.bsky.social in the same issue of NSMB. A growing thicket of THIK structures 😃
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Structure of the human K2P13.1 channel reveals a hydrophilic pore restriction and lipid cofactor site - Nature Structural & Molecular Biology
Roy-Chowdhury et al. report structures of the human leak channel K2P13.1 that identify a hydrophilic pore restriction and a polyunsaturated-fatty-acid-binding site corresponding to a small-molecule ag...
www.nature.com
February 26, 2025 at 5:47 PM
Our THIK study of the THIK K2P is out showing a novel feature that affects function (flow restrictor) and a PUFA modulation site. Congratulations to my team. 🥳 See also work by @profkalium.bsky.social in the same issue of NSMB. A growing thicket of THIK structures 😃
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns with @dirktrauner.bsky.social, Carmena Lab, and Lammel Lab.
Check out our latest application of proximity-based photopharmacology (PBPP), published in Neuron.
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns
Timed dopamine signals underlie reinforcement learning, favoring neural activity patterns that drive behaviors with positive outcomes. In the striatum…
www.sciencedirect.com
February 14, 2025 at 6:47 PM
Dopamine D1 receptor activation in the striatum is sufficient to drive reinforcement of anteceding cortical patterns with @dirktrauner.bsky.social, Carmena Lab, and Lammel Lab.
Reposted by Ehud Isacoff Lab
Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels).
portlandpress.com/biochemsoctr...
portlandpress.com/biochemsoctr...
Electrosome assembly: Structural insights from high voltage-activated calcium channel (CaV)–chaperone interactions
Ion channels are multicomponent complexes (termed here as“electrosomes”) that conduct the bioelectrical signals required for life. It has been appreciated for decades that assembly is critical for pro...
portlandpress.com
February 7, 2025 at 1:13 PM
Glad to share a new minireview with Zhou Chen summarizing our current thoughts on how cells make electrosomes (aka ion channels).
portlandpress.com/biochemsoctr...
portlandpress.com/biochemsoctr...