🧠 Key takeaway: Cognitive resilience hinges on preserving excitatory-inhibitory homeostasis. Specific “surge-protector” neurons control excess firing and shield the cortex even when plaques and tangles are abundant.

For me what helped me the most was changing my mindset to "What's the worst that can happen? Me not getting the PhD? It's not going to happen, but if it does, I can leave with that! Not worth the price of my physical and mental health!". Still, bloody difficult, though. Keep swimming. Almost there.

Thank you to @alzheimersresearchuk.org & @alzheimerssoc.bsky.social for supporting this work.

🔍 Main findings:

• Tau vs Aβ → pathology-specific DNA methylation remodeling
• Larger effects in the hippocampus
• Convergence with human studies: ANK1, PRDM16, SATB1
• Accelerated epigenetic age with tau accumulation

#Tau #Amyloid #Alzheimer #EndAlz #Epigenetics

I keep saying that scientists come in all shapes & forms! Even the other day I was telling someone that a few years ago when I was an organizer of @soapboxscience.bsky.social Exeter, I tried to bring in professors & students, of course, but also RAs, core leads, etc. I certainly see you! :)

@laurenfish.bsky.social
#TainLuquez
@susanrohde.bsky.social @baldassogabi.bsky.social