Isabella Menart
@isabellamenart.bsky.social
Originally from Slovenia, currently living in Uppsala 🇸🇪
PhD Candidate @uu.se at Ivarsson lab studying #evolution of #structure and #function in #denovo microproteins.
Dark proteome explorer 🚀 lover of #IDPs🍜 and #SLiMs🧩
PhD Candidate @uu.se at Ivarsson lab studying #evolution of #structure and #function in #denovo microproteins.
Dark proteome explorer 🚀 lover of #IDPs🍜 and #SLiMs🧩
If you think de novo proteins are interesting, and you want to learn more about protein evolution in general, stay tuned for more #evolutionarybiochemistry and #denovo content!
🧵9/9
🧵9/9
March 16, 2025 at 5:03 PM
If you think de novo proteins are interesting, and you want to learn more about protein evolution in general, stay tuned for more #evolutionarybiochemistry and #denovo content!
🧵9/9
🧵9/9
That's where my PhD comes in💡. My aim is to study the structure and folding of these proteins and draw conclusions about the evolution of structure in the early stages of protein birth. I also want to see whether these proteins can integrate into existing interaction networks in the cell.
🧵8/9
🧵8/9
March 16, 2025 at 5:03 PM
That's where my PhD comes in💡. My aim is to study the structure and folding of these proteins and draw conclusions about the evolution of structure in the early stages of protein birth. I also want to see whether these proteins can integrate into existing interaction networks in the cell.
🧵8/9
🧵8/9
Their research revealed a wide spectrum of folding propensities, from entirely disordered to compactly folded new proteins! It opens up many possibilities to study their structures more in depth.
🧵 7/9
🧵 7/9
March 16, 2025 at 5:03 PM
Their research revealed a wide spectrum of folding propensities, from entirely disordered to compactly folded new proteins! It opens up many possibilities to study their structures more in depth.
🧵 7/9
🧵 7/9
A good starting point to understanding the function of any protein is to look at its structure. In this paper, the groups of @bornberglab.bsky.social and @KlaraHlouchova have designed a #FRET-FACS based assay that estimates the folding propensity of de novo proteins.
🧵 6/9
🧵 6/9
High-throughput Selection of Human de novo-emerged sORFs with High Folding Potential
Abstract. De novo genes emerge from previously noncoding stretches of the genome. Their encoded de novo proteins are generally expected to be similar to ra
academic.oup.com
March 16, 2025 at 5:03 PM
A good starting point to understanding the function of any protein is to look at its structure. In this paper, the groups of @bornberglab.bsky.social and @KlaraHlouchova have designed a #FRET-FACS based assay that estimates the folding propensity of de novo proteins.
🧵 6/9
🧵 6/9
Publications like the one from Prensner et al. have shown that some de novo proteins could be implicated in diseases such as cancer. It is therefore important that we continue to look into their origins and functions, to better understand them.
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧵 5/9
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧵 5/9
Non-canonical open reading frames encode functional proteins essential for cancer cell survival
Although genomic analyses predict many non-canonical open reading frames (ORFs) in the human genome, it is unclear whether they encode biologically active proteins. Here, we experimentally interrogate...
pmc.ncbi.nlm.nih.gov
March 16, 2025 at 5:03 PM
Publications like the one from Prensner et al. have shown that some de novo proteins could be implicated in diseases such as cancer. It is therefore important that we continue to look into their origins and functions, to better understand them.
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧵 5/9
pmc.ncbi.nlm.nih.gov/articles/PMC...
🧵 5/9
A protein is considered de novo only if it arises from a previously non-coding segment of DNA, and is thus entirely unique from existing proteins. Although most de novo proteins will disappear soon after their birth, some carry beneficial functions and become fixed in a population’s genome.
🧵 4/9
🧵 4/9
March 16, 2025 at 5:03 PM
A protein is considered de novo only if it arises from a previously non-coding segment of DNA, and is thus entirely unique from existing proteins. Although most de novo proteins will disappear soon after their birth, some carry beneficial functions and become fixed in a population’s genome.
🧵 4/9
🧵 4/9
Since I am new to the Bluesky community, it's only appropriate that I introduce myself and my research. My name is Isabella, and I am a PhD student at @uu.se studying #evolution of #protein structure and function. And I think you should come explore the vast space of de novo proteins with me!🚀
🧵3/9
🧵3/9
March 16, 2025 at 5:03 PM
Since I am new to the Bluesky community, it's only appropriate that I introduce myself and my research. My name is Isabella, and I am a PhD student at @uu.se studying #evolution of #protein structure and function. And I think you should come explore the vast space of de novo proteins with me!🚀
🧵3/9
🧵3/9
Our cells are constantly innovating new, never-before-seen proteins, that could carry out novel functions. The field of naturally evolved #denovo proteins has been searching for these elusive new proteins and trying to understand how and why they appear, and what their function is.
🧵2/9
🧵2/9
March 16, 2025 at 5:03 PM
Our cells are constantly innovating new, never-before-seen proteins, that could carry out novel functions. The field of naturally evolved #denovo proteins has been searching for these elusive new proteins and trying to understand how and why they appear, and what their function is.
🧵2/9
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