Bella Lin
banner
isabellalin.bsky.social
Bella Lin
@isabellalin.bsky.social
PhD student @ Harvard Med | Cornell alum
Reposted by Bella Lin
Here we show that >90% of Paenibacillus encode a unique Spo0B with a transmembrane domain! TM domain helps it interact with its phosphorelay partners. Congrats to @isabellalin.bsky.social who left for grad school this week and her mentor @cassidyprints.bsky.social! www.biorxiv.org/content/10.1...
Conservation of sporulation genes and a transmembrane-containing Spo0B variant in Paenibacillus
Sporulation is a strategy employed by many bacteria to survive harsh environmental conditions. The genus Paenibacillus includes spore-forming species notorious for spoiling pasteurized dairy products ...
www.biorxiv.org
August 28, 2025 at 11:27 PM
Reposted by Bella Lin
Awesome work from my mentee @isabellalin.bsky.social on sporulation in non-model Bacilli!!
Conservation of sporulation genes and a transmembrane-containing Spo0B variant in Paenibacillus https://www.biorxiv.org/content/10.1101/2025.08.24.672004v1
August 25, 2025 at 2:08 PM
Reposted by Bella Lin
Just published the first chapter of my thesis! 🥰

E. coli regulates the levels of a translation release factor (RF2) via a *purposeful* frameshift during translation. We found that most other bacteria do this too and it's likely an ancient mechanism!

journals.asm.org/doi/10.1128/...
Conservation and evolution of the programmed ribosomal frameshift in prfB across the bacterial domain | mBio
Translation termination is catalyzed by one of two release factors in bacteria, RF1 or RF2. It has been known for decades that RF2 levels in Escherichia coli are regulated by a programmed ribosomal frameshift within the prfB gene that encodes RF2. We ...
journals.asm.org
August 19, 2025 at 5:39 PM
Reposted by Bella Lin
Bella Lin @isabellalin.bsky.social will be attending Harvard BBS for her PhD!! We’re so proud of you Bella! 🍾🎉
March 11, 2025 at 6:42 PM