Bel Esain
@isabelesain.bsky.social
PostDoc @Doudna_lab 🧬| PhD @Cambridge_Uni | @Harvard @imperialcollege - I like epigenetics and editing genes. Life begins at the end of your comfort zone✨✈️🌍⛵️🎿
Reposted by Bel Esain
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 6:04 PM
Excited to share our first work on protein design! Huge thanks to the entire team, and especially to Bel, Evan, to the Doudna, Jacobsen, Cate, Banfield labs, all co-authors, and my D-lab mates! 💫
Reposted by Bel Esain
Excited to share our work designing genome editors with machine learning! 🧬💻 Huge thanks to
@petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇
@petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 11:36 AM
Excited to share our work designing genome editors with machine learning! 🧬💻 Huge thanks to
@petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇
@petrskopintsev.bsky.social @isabelesain.bsky.social @doudna-lab.bsky.social and all co-authors. Check out the thread for a summary of what we found 👇
Reposted by Bel Esain
Big congrats to @petrskopintsev.bsky.social and @isabelesain.bsky.social !
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 4:49 PM
Big congrats to @petrskopintsev.bsky.social and @isabelesain.bsky.social !
First co-led work from the Doudna lab 🤜🤛
We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
✨New preprint!
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al!
Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬
🔗👇
December 9, 2025 at 9:23 AM
First co-led work from the Doudna lab 🤜🤛
We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
We designed minimal RNA-guided nucleases with AI, and even did Cryo-EM during an earthquake (!) Huge honor working with @petrskopintsev.bsky.social, @evandeturk.bsky.social, Jennifer Doudna and co-authors, everyone at D-Lab and @innovativegenomics.bsky.social
Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️
New in Science Magazine from the Doudna Lab and first author Owen Tuck: Recurrent acquisition of nuclease-protease pairs in antiviral immunity. Read here: https://ow.ly/pIWQ50XtEtM
Recurrent acquisition of nuclease-protease pairs in antiviral immunity
Antiviral immune systems diversify by integrating new genes into existing pathways, creating new mechanisms of viral resistance. We identified genes encoding a predicted nuclease paired with a trypsin-like protease repeatedly acquired by multiple, ...
ow.ly
November 26, 2025 at 2:46 AM
Incredible work by @owentuck.bsky.social, Jason Hu et al 👏🏼 Antiviral systems repeatedly acquire nuclease–protease pairs to fight viruses ⚔️
Super cool work by @erinedoherty.bsky.social and @jnoms.bsky.social ! 💪🏼
Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬
Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬
Work I co-led with @jnoms.bsky.social is now online at
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
@cp-cellhostmicrobe.bsky.social ! We revealed a previously unrealized diversity of viral immune-evasion proteins that selectively destroy different cyclic nucleotide signals used in bacterial immunity.
www.sciencedirect.com/science/arti...
Divergent viral phosphodiesterases for immune signaling evasion
Cyclic dinucleotides (CDNs) and other short oligonucleotides play fundamental roles in immune system activation in organisms ranging from bacteria to …
www.sciencedirect.com
November 26, 2025 at 2:38 AM
Super cool work by @erinedoherty.bsky.social and @jnoms.bsky.social ! 💪🏼
Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬
Viruses hack bacterial immunity by breaking down the nucleotide signals that trigger defence 🦠🧬
Reposted by Bel Esain
👩🏻🔬La investigadora española @isabelesain.bsky.social ha sido galardonada por su tesis doctoral contra el #cáncer en el @cruk-mi.bsky.social.
🗣️"El genoma humano es como un libro que tiene muchos capítulos".
🎬 En @aragontv.bsky.social.
www.cartv.es/aragonnotici...
El Reino Unido reconoce la tesis de una zaragozana que busca una solución universal contra el cáncer
La joven Isabel Esaín ha ganado el premio Cambridge que entrega el Instituto para la Investigación del Cáncer en el Reino Unido. Su trabajo ha descubierto un mecanismo que podría controlar las mutacio...
www.cartv.es
January 19, 2025 at 8:51 AM
👩🏻🔬La investigadora española @isabelesain.bsky.social ha sido galardonada por su tesis doctoral contra el #cáncer en el @cruk-mi.bsky.social.
🗣️"El genoma humano es como un libro que tiene muchos capítulos".
🎬 En @aragontv.bsky.social.
www.cartv.es/aragonnotici...
So honored to receive the Best Thesis Prize❤️ @cambridgeuni.bsky.social @cruk-ci.bsky.social still feels surreal. Thank you to CRUK, my supervisors for believing in my ideas, and my former lab members, friends and family for always supporting me. So grateful to be part of such an inspiring community!
Congratulations to @isabelesain.bsky.social, who is awarded the 2024 CRUK Cambridge Institute PhD Thesis Prize.
In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments.
www.cruk.cam.ac.uk/news/bel-esa...
In her doctoral research, Bel discovered a new molecular mechanism in cancer gene regulation opening up a new therapeutic window for cancer treatments.
www.cruk.cam.ac.uk/news/bel-esa...
December 3, 2024 at 4:13 PM
So honored to receive the Best Thesis Prize❤️ @cambridgeuni.bsky.social @cruk-ci.bsky.social still feels surreal. Thank you to CRUK, my supervisors for believing in my ideas, and my former lab members, friends and family for always supporting me. So grateful to be part of such an inspiring community!
Reposted by Bel Esain
🚨 The Alker Lab is starting at the University of Rhode Island in early 2025 and we will be hiring! 🚨
If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊
If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊
November 30, 2024 at 12:14 AM
🚨 The Alker Lab is starting at the University of Rhode Island in early 2025 and we will be hiring! 🚨
If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊
If you are interested in marine microbiology, bacterial genetics and/or symbiosis, please consider reaching out! Repost to help spread the word 🪸🧪🧬🌊