Stretch-mediated β₂-adrenergic signaling in cardiomyocytes depends on caveolae. Using the IonOptix CytoCypher MultiCell, researchers showed stretch increases contractility and cAMP via β₂AR—not β₁AR—and is lost when caveolae are disrupted. shorturl.at/AgbtN

Mechanical loading reveals hidden cardiomyocyte stiffness in cardiometabolic disease. Using IonOptix MyoStretcher and Calcium & Contractility systems, researchers found HFSD-fed mice had stiffer cells and slower Ca²⁺ decay—signs of diastolic dysfunction. shorturl.at/xDazR

A recent study reveals how a titin mutation alters thick filament length, driving dilated cardiomyopathy. Using the IonOptix MyoStretcher and CytoCypher MultiCell Systems, researchers measured changes in force, sarcomere length, and calcium handling. shorturl.at/H9b2r

Researchers modeled hypertrophic cardiomyopathy using human cardiac organoids derived from hiPSC-CMs carrying the MYBPC3 D389V variant. Using the IonOptix CytoCypher MultiCell System, they measured faster contractility and calcium kinetics. shorturl.at/rKqnN

In this Cardiovascular Research study, researchers used IonOptix’s MyoStretcher and MultiCell systems to assess stiffness and calcium handling in cardiomyocytes. Targeting titin isoforms via Rbm20-ASO reduced stiffness and improved diastolic function. shorturl.at/UCf89

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity.
Read more: shorturl.at/9TEEr

Such a pleasure to have Hanan from @ionoptix.bsky.social to come to FSU to help us setup this Ca2+ and contrqctility system to assess #cardiomyocyte function 🔬🧫🫀

Calcium transient imaging using an @ionoptix.bsky.social setup. On the bottom of the screen we can the pretty cardiomyocyte "beating". 🧪

Researchers used IonOptix cardiomyocyte systems to study GPR41 function. Butyrate reduced cell shortening and Ca²⁺ transients in WT but not GPR41−/− mice, implicating GPR41 in modulating inotropy via cAMP signaling and SERCA2a activity.
Read more: shorturl.at/9TEEr

Researchers used the IonOptix CytoCypher MultiCell to compare calcium handling and contractility in hiPSC-cardiomyocytes with or without sympathetic neurons. Coculture enhanced inotropy, chronotropy, and structure—supporting improved maturation. shorturl.at/fldct

Researchers feature IonOptix systems while highlighting the value of intact cardiomyocytes and tissue slices in HFpEF research. Preserving native environments yields more physiologically relevant insights than skinned preps.
Read more: shorturl.at/bK3pU

Using the IonOptix MyoStretcher, researchers revealed that diastolic dysfunction in a novel ovary-intact HFpEF mouse model stems from increased stiffness in ventricular myocytes—highlighting a link between menopause and HFpEF.
Read more: shorturl.at/T7gse

In this Journal of Molecular and Cellular Cardiology Plus publication from researchers at UVM, Hancock et al. demonstrate a novel method utilizing living myocardial slices to model early and late stage diastole using their IonOptix Cardiac Slice System. shorturl.at/4ShI6