Intensive Care Medicine Journal
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Intensive Care Medicine serves as the premier publication platform facilitating the communication and exchange of cutting-edge research and ideas within the field of intensive care medicine on a comprehensive scale. This platform is designed for profession
Norepinephrine is increasingly used in perioperative care for haemodynamic management, with benefits in stabilising blood pressure during surgery and reducing adverse outcomes linked to hypotension. zurl.co/kFyFN
November 24, 2025 at 9:00 AM
Norepinephrine is increasingly used in perioperative care for haemodynamic management, with benefits in stabilising blood pressure during surgery and reducing adverse outcomes linked to hypotension. zurl.co/kFyFN
#1minutevideo Higher hospital-level use of continuous kidney replacement therapy in critically ill patients with AKI was linked to lower risk-adjusted mortality, suggesting that greater CKRT utilisation may reflect more effective care. zurl.co/zTsVe
November 23, 2025 at 5:01 PM
#1minutevideo Higher hospital-level use of continuous kidney replacement therapy in critically ill patients with AKI was linked to lower risk-adjusted mortality, suggesting that greater CKRT utilisation may reflect more effective care. zurl.co/zTsVe
A 4D trial analysis finds dexmedetomidine shows a global benefit in non-intubated ICU hyperactive delirium, with less rescue medication and no safety signals, while questioning joint Z-score endpoints and early stopping for efficacy. zurl.co/jncbI
November 23, 2025 at 9:00 AM
A 4D trial analysis finds dexmedetomidine shows a global benefit in non-intubated ICU hyperactive delirium, with less rescue medication and no safety signals, while questioning joint Z-score endpoints and early stopping for efficacy. zurl.co/jncbI
Invasive meningococcal disease is rare yet deadly, with post-pandemic rebounds and shifting serogroups. Early recognition and antibiotics improve survival, while hemodynamic failure drives mortality and sequelae. zurl.co/vrjap
November 22, 2025 at 5:00 PM
Invasive meningococcal disease is rare yet deadly, with post-pandemic rebounds and shifting serogroups. Early recognition and antibiotics improve survival, while hemodynamic failure drives mortality and sequelae. zurl.co/vrjap
Bedside guidance on vasopressin in septic shock: start early with norepinephrine, use fixed low doses with 0.005 IU/min titration, prefer central access, monitor for digital ischaemia; major trials found no overall survival benefit. zurl.co/1bsJo
November 22, 2025 at 9:00 AM
Bedside guidance on vasopressin in septic shock: start early with norepinephrine, use fixed low doses with 0.005 IU/min titration, prefer central access, monitor for digital ischaemia; major trials found no overall survival benefit. zurl.co/1bsJo
#VisualAbstract Invasive candidiasis in ICU care demands faster rule-in/rule-out diagnostics, risk-stratified therapy and rigorous stewardship. Rising non-albicans species and resistance make team-based management and source control key to improving outcomes. zurl.co/c7fhh
November 21, 2025 at 5:00 PM
#VisualAbstract Invasive candidiasis in ICU care demands faster rule-in/rule-out diagnostics, risk-stratified therapy and rigorous stewardship. Rising non-albicans species and resistance make team-based management and source control key to improving outcomes. zurl.co/c7fhh
Authors state that ‘early’ mobilisation in ICU after surgery should use 72 hours as an upper boundary within ERAS, alongside prehabilitation. Evidence shows no overall advantage for 24 versus 72 hours, and stronger randomised data are still needed. zurl.co/RklsU
November 21, 2025 at 9:00 AM
Authors state that ‘early’ mobilisation in ICU after surgery should use 72 hours as an upper boundary within ERAS, alongside prehabilitation. Evidence shows no overall advantage for 24 versus 72 hours, and stronger randomised data are still needed. zurl.co/RklsU
In 77 critically ill adults on ceftriaxone, higher unbound 24-h AUC was associated with faster CRP decline over 10 days than lower exposure, after adjustment, suggesting value for exposure-guided dosing while acknowledging observational limits. zurl.co/NGrJv
November 20, 2025 at 5:00 PM
In 77 critically ill adults on ceftriaxone, higher unbound 24-h AUC was associated with faster CRP decline over 10 days than lower exposure, after adjustment, suggesting value for exposure-guided dosing while acknowledging observational limits. zurl.co/NGrJv
#ICM-Quizz #MedEd Pulmonary artery pulse pressure and an EtCO₂ waveform of 17 mmHg indicate that atrial activity sustains transpulmonary flow and pulmonary venous return. In VA-ECMO without native ejection, EtCO₂ tends to fall below 10 mmHg. zurl.co/5XREe
November 20, 2025 at 9:00 AM
#ICM-Quizz #MedEd Pulmonary artery pulse pressure and an EtCO₂ waveform of 17 mmHg indicate that atrial activity sustains transpulmonary flow and pulmonary venous return. In VA-ECMO without native ejection, EtCO₂ tends to fall below 10 mmHg. zurl.co/5XREe
Deaths dominate the MAKE composite after KDIGO stage-3 AKI, diluting kidney-specific signals. With 51% MAKE, deaths were 32%, long-term dialysis 12% and persistent dysfunction 7%. Kidney-centred analyses treating death as a competing risk are urged. zurl.co/Tyq5v
November 19, 2025 at 9:00 AM
Deaths dominate the MAKE composite after KDIGO stage-3 AKI, diluting kidney-specific signals. With 51% MAKE, deaths were 32%, long-term dialysis 12% and persistent dysfunction 7%. Kidney-centred analyses treating death as a competing risk are urged. zurl.co/Tyq5v
Pharmaceutical poisonings make up to 10% of ICU admissions. The review outlines ABCDE-based stabilisation and when to escalate from supportive care to decontamination, extracorporeal removal, antidotes, lipid emulsion or VA-ECMO. zurl.co/DwBcm
November 18, 2025 at 5:00 PM
Pharmaceutical poisonings make up to 10% of ICU admissions. The review outlines ABCDE-based stabilisation and when to escalate from supportive care to decontamination, extracorporeal removal, antidotes, lipid emulsion or VA-ECMO. zurl.co/DwBcm
A nine-hospital survey finds ICU staff are motivated to act sustainably: median intrinsic time is 5 minutes/day and 59.6% would give ≥5 minutes; awareness, training and intensivist role boost engagement, and recognition can raise effort. zurl.co/qLWKw
November 18, 2025 at 9:00 AM
A nine-hospital survey finds ICU staff are motivated to act sustainably: median intrinsic time is 5 minutes/day and 59.6% would give ≥5 minutes; awareness, training and intensivist role boost engagement, and recognition can raise effort. zurl.co/qLWKw
#VisualAbstract Across 47 French ICUs, ventilator weaning was longer in Guillain–Barré syndrome than in myasthenia gravis; tracheostomy was more frequent, and extubation attempts fewer in Guillain–Barré, while reintubation and mortality were similar. zurl.co/VyYGU
November 17, 2025 at 5:00 PM
#VisualAbstract Across 47 French ICUs, ventilator weaning was longer in Guillain–Barré syndrome than in myasthenia gravis; tracheostomy was more frequent, and extubation attempts fewer in Guillain–Barré, while reintubation and mortality were similar. zurl.co/VyYGU
Pre-arrest frailty, assessed by the Clinical Frailty Scale, was linked to higher mortality and poorer functional outcomes after out-of-hospital cardiac arrest, with frail survivors more likely to report functional decline and lower health status. zurl.co/PUBuj
November 17, 2025 at 9:00 AM
Pre-arrest frailty, assessed by the Clinical Frailty Scale, was linked to higher mortality and poorer functional outcomes after out-of-hospital cardiac arrest, with frail survivors more likely to report functional decline and lower health status. zurl.co/PUBuj
Cognitive reserve may refine post-ICU recovery stratification, using proxies such as education, occupation and lifestyle, but socioeconomic data should be applied to support care and avoid reinforcing disparities. zurl.co/DkzHG
November 16, 2025 at 5:00 PM
Cognitive reserve may refine post-ICU recovery stratification, using proxies such as education, occupation and lifestyle, but socioeconomic data should be applied to support care and avoid reinforcing disparities. zurl.co/DkzHG
PO-AKI prevention includes biomarker-guided KDIGO bundles, balanced crystalloids to finish ~1–2 L positive, and avoiding 20% albumin; continuing ACEi/ARB shows no difference in AKI risk. zurl.co/pVr6s
November 16, 2025 at 9:00 AM
PO-AKI prevention includes biomarker-guided KDIGO bundles, balanced crystalloids to finish ~1–2 L positive, and avoiding 20% albumin; continuing ACEi/ARB shows no difference in AKI risk. zurl.co/pVr6s
#VisualAbstract ICU RCT meta-analysis: melatonin did not prevent delirium (RR 0.89 primary; 0.86 secondary) or reduce mortality. Trial-sequential analysis signalled futility, so further trials are unlikely to change this conclusion. zurl.co/LPi1v
November 15, 2025 at 5:00 PM
#VisualAbstract ICU RCT meta-analysis: melatonin did not prevent delirium (RR 0.89 primary; 0.86 secondary) or reduce mortality. Trial-sequential analysis signalled futility, so further trials are unlikely to change this conclusion. zurl.co/LPi1v
A personalised approach to prone positioning in acute brain injury is advocated, using multimodal neuromonitoring to guide care, with non-invasive tools supporting invasive intracranial pressure monitoring. zurl.co/OTRps
November 15, 2025 at 9:00 AM
A personalised approach to prone positioning in acute brain injury is advocated, using multimodal neuromonitoring to guide care, with non-invasive tools supporting invasive intracranial pressure monitoring. zurl.co/OTRps
Pcv-aCO2/Ca-cvO2 poorly reflects respiratory quotient and anaerobic metabolism; experiments and a multicentre trial signalled harm when CO2-derived targets guided resuscitation. zurl.co/0HEoo
November 14, 2025 at 5:00 PM
Pcv-aCO2/Ca-cvO2 poorly reflects respiratory quotient and anaerobic metabolism; experiments and a multicentre trial signalled harm when CO2-derived targets guided resuscitation. zurl.co/0HEoo
In septic shock, randomisation-inference of SEPSIS-PAM found no moderate to large heterogeneity between higher and lower MAP targets; mediation analyses linked higher norepinephrine need or persistent mottling with higher mortality. zurl.co/TmOPI
November 14, 2025 at 9:00 AM
In septic shock, randomisation-inference of SEPSIS-PAM found no moderate to large heterogeneity between higher and lower MAP targets; mediation analyses linked higher norepinephrine need or persistent mottling with higher mortality. zurl.co/TmOPI
#VisualAbstract A UK-endorsed ECMO emergency algorithm supports frontline staff: confirm arrest with MAP<30 mmHg, split into patient/device teams, restore flow via stepwise troubleshooting, and deliver structured resuscitation training. zurl.co/3Q7nN
November 13, 2025 at 5:00 PM
#VisualAbstract A UK-endorsed ECMO emergency algorithm supports frontline staff: confirm arrest with MAP<30 mmHg, split into patient/device teams, restore flow via stepwise troubleshooting, and deliver structured resuscitation training. zurl.co/3Q7nN
Ultrasound presets help lung imaging, but many devices lack one; low gain can reveal B-lines and pleural movement, and settings should be tailored to the clinical question. zurl.co/QIrei
November 13, 2025 at 9:00 AM
Ultrasound presets help lung imaging, but many devices lack one; low gain can reveal B-lines and pleural movement, and settings should be tailored to the clinical question. zurl.co/QIrei
A Markov model re-analysis of ACURASYS suggests neuromuscular blockade benefits younger ARDS patients with non-fatal McCabe scores, with no clear benefit in older or rapidly fatal cases, supporting selective, individualised use. zurl.co/5uiSI
November 12, 2025 at 5:00 PM
A Markov model re-analysis of ACURASYS suggests neuromuscular blockade benefits younger ARDS patients with non-fatal McCabe scores, with no clear benefit in older or rapidly fatal cases, supporting selective, individualised use. zurl.co/5uiSI
In intensive care, acute encephalopathy should be the unifying term, with delirium and coma as phenotypes, to align care with neurobiology and avoid delays from psychiatric labelling. zurl.co/athd7
November 12, 2025 at 9:00 AM
In intensive care, acute encephalopathy should be the unifying term, with delirium and coma as phenotypes, to align care with neurobiology and avoid delays from psychiatric labelling. zurl.co/athd7