Iason Keramidis
@ikeram.bsky.social
Postdoc @Stanford & the Schnitzer lab.
Measuring network dynamics of multiple neuron types across multiple brain areas during memory encoding.
PhD in neuroscience (advisor: Prof. Yves De Koninck)
Measuring network dynamics of multiple neuron types across multiple brain areas during memory encoding.
PhD in neuroscience (advisor: Prof. Yves De Koninck)
🆕 paper, now online!
We show that chronic hippocampus optogenetic activation in wild-type mice drives Alzheimer–like proteomic remodeling, supporting the notion that neuronal hyperactivity may disrupt proteostatic regulation in ways that mirror the prodromal phase of AD www.cell.com/iscience/ful...
We show that chronic hippocampus optogenetic activation in wild-type mice drives Alzheimer–like proteomic remodeling, supporting the notion that neuronal hyperactivity may disrupt proteostatic regulation in ways that mirror the prodromal phase of AD www.cell.com/iscience/ful...
Chronic optogenetic activation of hippocampal CA1 neurons triggers Alzheimer’s disease-like proteomic remodeling
Molecular neuroscience; Cellular neuroscience; Proteomics
www.cell.com
September 15, 2025 at 1:55 AM
🆕 paper, now online!
We show that chronic hippocampus optogenetic activation in wild-type mice drives Alzheimer–like proteomic remodeling, supporting the notion that neuronal hyperactivity may disrupt proteostatic regulation in ways that mirror the prodromal phase of AD www.cell.com/iscience/ful...
We show that chronic hippocampus optogenetic activation in wild-type mice drives Alzheimer–like proteomic remodeling, supporting the notion that neuronal hyperactivity may disrupt proteostatic regulation in ways that mirror the prodromal phase of AD www.cell.com/iscience/ful...
September 12, 2025 at 7:01 PM