Would definitely be curious to hear your thoughts! (Doesn't have to be in a public forum though 😆, feel free to email me!). I'm a big fan of your work

It was amazing working on this with Ethan Richman, Tony Liu, @deisseroth.bsky.social, @crodriguezmdphd.bsky.social ‬, @samvesuna.bsky.social and many others. And we are very grateful for the incredible contributions of the participants who volunteered to be in the study.

We hypothesize that aspects of the etiology and treatment of certain neuropsychiatric disorders may be governed by alteration of such persistence-related phenomena.

By analogy to a piano's sustain pedal, emotional responses to sensory stimuli require the brain's "sustain pedal" to be activated, allowing signals to persist and accumulate.

One high level takeaway is that emergence of emotional responses in mammals seems to rely on the brain's capacity to sustain persistent activity dynamics. By pharmacologically disrupting this ability of the brain, we blunt emotional responses in both humans and mice.