International Journal of Particle Therapy
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International Journal of Particle Therapy
@ijpt.bsky.social
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The official journal of the Particle Therapy Cooperative Group (PTCOG). The IJPT is published quarterly by Elsevier and is an open access journal: https://www.sciencedirect.com/journal/international-journal-of-particle-therapy
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ijpt.bsky.social
Read the results of an important survey of 29 U.S. proton therapy centers assessing awareness and management of relative biological effectiveness variability in clinical practice: www.sciencedirect.com/science/arti...
Figure 1. Assumption of a constant relative biological effectiveness (RBE) of 1.1: Responses on the level of (a) overall concern [Q3] and (b) urgency for revision of current practice for normal tissue [Q4]. Distribution in percent (number of responses).
November 14, 2025 at 7:08 PM
ijpt.bsky.social
Our first AI in Particle Therapy Special Issue article is available! Learn how a novel #AI approach models the evolution of visual field deficits in patients with para-optic tumors treated using pencil beam scanning #protontherapy - www.sciencedirect.com/special-issu...
Fig. 1. Workflow for archetypal and modeling analysis of optical damage pattern evaluation after radiotherapy.
November 12, 2025 at 5:39 PM
ijpt.bsky.social
In press now: #kidneycancer represents 4% of all new #Cancer cases in the US. Read a study that suggests #Proton based #SBRT improves target coverage while reducing the dose to primary renal cell carcinoma patient OARs: www.sciencedirect.com/science/arti...
Fig. 1. Representative color wash images in axial (left), coronal (middle), and sagittal (right) planes comparing protons (top row) versus photon (bottom row) based SBRT dose deposition for primary RCC. As shown, the target receives similar coverage in the two planes, with greater sparing of nearby structures with protons including the healthy part of the kidneys, stomach, bowel and liver.
October 27, 2025 at 3:02 PM
ijpt.bsky.social
Numerous factors influence #protontherapy treatment times & with 29 new centers opened in the last 5 years, #NAPT reports these patients have tripled. Read treatment time insights from the Miami Cancer Institute’s RTLS system #RTLS system - www.sciencedirect.com/science/arti... #cancer #radonc
Fig. 1. Diagram of the proton clinic RTLS sensors/zones. The colors indicate room status (green for available and yellow for occupied).
October 6, 2025 at 1:15 PM
ijpt.bsky.social
In press now: Read a UF Health Proton Therapy study that developed & validated an automated framework for #protontherapy plan review, enhancing error detection capabilities & workflow efficiency in pencil beam scanning: www.sciencedirect.com/science/arti... #PBS #radonc #MedPhys #cancerresearch
Fig. 2. Treatment plan review workflow incorporating Auto-IniCheck for initial plan assessment. Auto-IniCheck is integrated into the initial plan review process for dosimetrists and physicists to enhance error detection and improve review efficiency. The figure illustrates the use of Auto-IniCheck with manual checks, streamlining the initial review process.
October 3, 2025 at 3:17 PM
ijpt.bsky.social
Excessive quality assurance computed tomography scans can increase patient burden, resources, & #healthcare costs. Read a John Hopkins School of Medicine study evaluating the impact of standardized minimum #QACT frequencies across treatment sites - sciencedirect.com/science/arti... #MedPhys #Cancer
Fig. 1. Alignment Issue Caught by CBCT. In both the CBCT and the QACT, the alignment is to the fiducials and it can be observed that the bony anatomy is then very off. This resulted in an adaptive plan. This highlights the usefulness of CBCTs in identifying patient anatomical changes that can reduce the standard QACT rates, instead triggering a QACT if anatomical changes, such as this bony vs fiducial alignment difference, are observed on CBCTs.
September 25, 2025 at 4:55 PM
ijpt.bsky.social
In press now: Read a collaborative Juntendo-Harvard study that suggests both #Xrays and #protons may induce #radiation-induced bystander responses in osteoblasts and osteoclasts, irrespective of cell combination, dose, or radiation type: www.sciencedirect.com/science/arti...
Figure 1. Experimental Materials. Figure 1A shows how differentiation is induced in MC3T3-E1 and RAW264.7 cells. Figure 1B illustrates the method of verifying the bystander effect and the structure of the items used for the experiment. Abbreviations: RANKL = receptor activator of nuclear factor kappa-B ligand.
September 16, 2025 at 6:04 PM
ijpt.bsky.social
Volume 17 is online now! Read articles related to #IMPT Versus #IMRT for #BreastCancer, #Protons or #Photons in pituitary #neuroendocrine tumors, NTCP-based prediction of lung sparing with IMPT, and more: www.sciencedirect.com/journal/inte...
September 8, 2025 at 3:27 PM
ijpt.bsky.social
Clear cell #adenocarcinoma of the uterine cervix is a rare and aggressive subtype of #cervicalcancer, typically resistant to conventional #RT. Read a case report in press with IJPT that suggests a #CIRT boost can achieve long-term local control: www.sciencedirect.com/science/arti... #cancerresearch
Fig. 3. Summed dose distribution of the two treatment plans Sum of the dose from external beam photon radiotherapy and carbon ion radiotherapy, expressed in EQD2.
August 14, 2025 at 2:10 PM
ijpt.bsky.social
Understanding how cells respond to & repair DNA damage is crucial for optimizing #radiotherapy - a new study evaluates how loss of different #DNA DSB repair genes impacts radiosensitivity: www.sciencedirect.com/science/arti... #MedPhys #RadOnc #ParticleTherapy #CancerResearch #protontherapy
Fig. 5. Medras accurately predicts radiation response in different cell models, shown by the correlation between Medras-predicted and experimentally obtained MID values.
July 28, 2025 at 12:06 PM
ijpt.bsky.social
Registration is now open for the #PTCOG-NA 11th Annual Meeting in Shreveport November 7-9, 2025. Take advantage of Early Bird Rates until August 20th! Learn more: www.ptcog-na.org/ptcog-na-11t...
July 17, 2025 at 7:37 PM
ijpt.bsky.social
In press with IJPT - learn about a novel method using an #XCT-PGD with on-board #CBCT for comprehensive 3D verification of #proton beam delivery accuracy: www.sciencedirect.com/science/arti... #MedPhys #RadOnc #ParticleTherapy #CancerResearch
Fig. 1. Experimental setup for the X-ray computed tomography polymer gel dosimeter (XCT-PGD). (a) Schematic diagram of the gel dosimeter in a cylindrical container placed inside an absorber. (b) Photograph of the actual setup on the treatment couch. The gel dosimeter is placed in an absorber and positioned using external lasers so that the center of its sensitive region aligns with the mechanical isocenter. The dosimeter is then secured in place with adhesive tape.
June 18, 2025 at 4:08 PM
ijpt.bsky.social
Volume 16 is complete & online now, featuring articles on #medulloblastoma from the Pediatric Proton/Photon Consortium Registry #PPCR, operational improvement of a #protontherapy system, & more: sciencedirect.com/journal/inte... #CancerResearch #radonc #MedPhys
June 6, 2025 at 2:21 PM
ijpt.bsky.social
In press now with IJPT: #IMPT vs. #IMRT provides excellent cardiac protection, particularly for left-sided IMNI and high-risk #breast cancer patients - learn more: www.sciencedirect.com/science/arti...
From Fig. 1. The irradiation field diagrams of IMPT and IMRT (A) and illustration of cardiac substructures delineation, mean dose, and isodose line distribution for IMPT and IMRT in left-sided (B) and right-sided (C) patients. Note: The mean dose to cardiac substructures is measured in cGy(RBE).
May 30, 2025 at 6:10 PM
ijpt.bsky.social
In press now: Learn how a tailored #QACT schedule based on beam trajectory and target location reduces unnecessary imaging without compromising treatment accuracy in cranial #protontherapy : sciencedirect.com/science/arti... #particletherapy #radonc #MedPhys
Fig. 1. Dosimetric Savings of 2 mm Plans. The dosimetric difference for each OAR clinical goal is shown for each patient.
May 22, 2025 at 3:42 PM
ijpt.bsky.social
Learn about the development of #step-and-shoot arc therapy (SPArc-step&shoot) for #headandneck #cancer treatment @BeaumontRadOnc @CorewellHealth - in press now with IJPT: www.sciencedirect.com/science/arti... #RadOnc #protontherapy
Fig. 1. Angular distribution of gantry angle vs. selected beam energy and number of protons per control point for SPArc-step&shoot and SPArc-dynamic.
April 21, 2025 at 12:12 PM
ijpt.bsky.social
Are you working on #AI applications in #ParticleTherapy? Learn more about our AI in PT Special Issue! Submission deadline is August 31, 2025, with publication at the close of 2025: www.sciencedirect.com/special-issu...
April 4, 2025 at 12:38 PM
ijpt.bsky.social
Join #PTCOG-NA for gumbo, gators and gantries! Abstract submission now open for the 11th Annual Meeting Nov 7-9, 2025 in Shreveport, LA. Deadline for submission is May 12th: www.ptcog-na.org/ptcog-na-11t...
March 28, 2025 at 8:21 PM
ijpt.bsky.social
#carbonion #radiotherapy is an emerging non-surgical treatment for early-stage #breastcancer - read the first study to evaluate pectoral myositis after C-ion RT, in press with IJPT now: www.sciencedirect.com/science/arti...
Fig. 1. A pectoral myositis and dose distributions of C-ion RT.
March 27, 2025 at 12:55 PM
ijpt.bsky.social
In Italy, where 3 facilities are dedicated to #protontherapy and others are planned, definitive selection guidelines for #headandneck #cancer patients have yet to be established. Read an analysis of a model-based selection strategy in this landscape: www.sciencedirect.com/science/arti...
Figure 1. Schematic proposal of NTCP-based MBS in Italy and interplay between the variables involved.
March 25, 2025 at 7:39 PM
ijpt.bsky.social
Volume 15 is online! Read about the value of #Hadrontherapy, #CarbonIon #RadiationTherapy, #radiomics for #PULSAR, and more: www.sciencedirect.com/journal/inte... #ParticleTherapy #CancerResearch #radonc #RadBio
March 10, 2025 at 12:15 PM
ijpt.bsky.social
In press now - Independent Review Organization appeals provide a valuable pathway to proton therapy access, with higher overturn rates improving significantly in recent years. Learn more: www.sciencedirect.com/science/arti...
From figure 2B: IRO Approval Rate by State
February 17, 2025 at 4:39 PM
ijpt.bsky.social
Head & neck mucosal melanomas are aggressive, radiotherapy-resistant cancers-read about early outcomes of carbon-ion radiotherapy at #MedAustron for HNMM using European and Japanese RBE-adapted dose prescriptions: www.sciencedirect.com/science/arti... #melanoma #headandneck #cancer #cancerresearch
January 9, 2025 at 1:06 PM
ijpt.bsky.social
What is the role of hadrontherapy in treating radioresistant, rare, recurrent, and radioinduced tumors? Begin the new year understanding the '4Rs of hadrontherapy with an international, multidisciplinary team of experts and IJPT: www.sciencedirect.com/science/arti...
Fig. 1. The 4Rs of hadrontherapy indications: R-adioresistant, R-are, R-ecurrent, and R-adioinduced tumours. Figure made by iInkscape Project.
January 2, 2025 at 2:25 PM
ijpt.bsky.social
December 13, 2024 at 3:44 PM