📅 November 21st, 11:30 AM
📍 Sala de Grados, Faculty of Biology, University of Murcia

Let’s support research that truly makes a difference! 💚✨

💙 This research was made possible thanks to support from KBG patient associations in Spain and the U.S. 🙌

💙 Esta tesis ha sido posible gracias al apoyo de asociaciones de pacientes de KBG en España y EE. UU. 🙌

I’ll give it a try, and if it doesn’t work out, I’ll get back to you. Thanks a lot.

Congrats Aya. Amazing story!!!

We are working with these 2 libraries from ENZO:
1. SCREEN-WELL® FDA approved drug library V2, BML-2843
2. SCREEN-WELL® Natural Product library, BML-2865
Each one has advantages and disadvantages. We can long discuss about it.

We have the p63(bac):gal4 and woyld be happy to share it

Thanks Jeff for this useful tool!!!

Congrats Miranda! Amazing work and useful new tool! I would be happy to discuss porential collaboration if you think your reporter may be useful to study inflammation and trained immunity!

🔍 The study reveals a novel antibacterial role for SAMHD1, previously known for antiviral defense
#Immunology #Zebrafish #HostDefense #InfectionBiology
@zebrafishrock.bsky.social

6/6
The study was led by @umutsendikasi.bsky.social, IMIB & CIBERER with financial support from Fundacion Seneca & AEI.
It showcases the power of rethinking existing drugs to meet urgent medical needs.
#Science #DBA #Inflammasome #Hematology

5/6
This discovery highlights a new erythropoietic activity of spironolactone that is independent of steroid receptors, making it a promising candidate for drug repurposing in DBA and possibly other ribosomopathies.

4/6
We found spironolactone specifically blocks NLRP1 activation, reduces caspase-1 activity, and promotes red blood cell differentiation—
In cell lines, zebrafish DBA models, and HSPCs from DBA patients.
No effect seen with its analog eplerenone.