freecell
@ifreecell.bsky.social
Discovery of Next Generation Therapeutics and Delivery Tools
Beyond Gene Editing: Exon Skipping Therapeutics
November 24, 2025 at 4:37 AM
Beyond Gene Editing: Exon Skipping Therapeutics
Non-canonical miRNA functions
November 24, 2025 at 3:26 AM
Non-canonical miRNA functions
Central role of skeletal muscle ageing in the pathogenesis of sarcopenia. www.sciencedirect.com/science/arti...
Potential pathways👇
✅insufficient myokine signalling (IL-6, 7, 15)
✅altered immune factors (pro-inflammatory profile)
✅impaired immune cell function
✅altered body composition
Potential pathways👇
✅insufficient myokine signalling (IL-6, 7, 15)
✅altered immune factors (pro-inflammatory profile)
✅impaired immune cell function
✅altered body composition
November 16, 2025 at 4:16 AM
Central role of skeletal muscle ageing in the pathogenesis of sarcopenia. www.sciencedirect.com/science/arti...
Potential pathways👇
✅insufficient myokine signalling (IL-6, 7, 15)
✅altered immune factors (pro-inflammatory profile)
✅impaired immune cell function
✅altered body composition
Potential pathways👇
✅insufficient myokine signalling (IL-6, 7, 15)
✅altered immune factors (pro-inflammatory profile)
✅impaired immune cell function
✅altered body composition
LNP for brain delivery
September 5, 2025 at 12:09 AM
LNP for brain delivery
Kraus et al. report absolute miRNA concentrations required for productive cleavage of highly expressed transcripts and identify mouse miRNAs that reach this threshold in vivo.
bit.ly/44cYNvj
bit.ly/44cYNvj
August 18, 2025 at 2:23 AM
Kraus et al. report absolute miRNA concentrations required for productive cleavage of highly expressed transcripts and identify mouse miRNAs that reach this threshold in vivo.
bit.ly/44cYNvj
bit.ly/44cYNvj
Research and Application of RNA Drugs in Kidney Diseases
March 22, 2025 at 2:16 AM
Research and Application of RNA Drugs in Kidney Diseases
The first step to use MS Exchange in an organization: servicedesk.msstate.edu/TDClient/45/...
March 3, 2025 at 2:14 AM
The first step to use MS Exchange in an organization: servicedesk.msstate.edu/TDClient/45/...
Mechanisms and comparison of ASOs. The ASOs regulate RNA function through different mechanisms. translationalneurodegeneration.biomedcentral.com/articles/10....
March 1, 2025 at 3:57 PM
Mechanisms and comparison of ASOs. The ASOs regulate RNA function through different mechanisms. translationalneurodegeneration.biomedcentral.com/articles/10....
www.mdpi.com/2076-3425/15... Modeling ALS with Patient-Derived iPSCs
March 1, 2025 at 3:46 PM
www.mdpi.com/2076-3425/15... Modeling ALS with Patient-Derived iPSCs
Functional assessment for therapeutic IgG mAbs academic.oup.com/abt/advance-...
March 1, 2025 at 3:40 PM
Functional assessment for therapeutic IgG mAbs academic.oup.com/abt/advance-...
BBB delivery using extracellular vesicles? www.cell.com/molecular-th...
February 23, 2025 at 3:27 PM
BBB delivery using extracellular vesicles? www.cell.com/molecular-th...
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications jbiomedsci.biomedcentral.com/articles/10....
February 23, 2025 at 3:23 PM
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications jbiomedsci.biomedcentral.com/articles/10....
"The versatility of CRAAVR cells for the streamlined testing and batch validation of AAVs for research and therapeutic applications."----but cannot be applied to all serotypes, such as AAV4. pubmed.ncbi.nlm.nih.gov/39944269/
February 22, 2025 at 3:34 PM
"The versatility of CRAAVR cells for the streamlined testing and batch validation of AAVs for research and therapeutic applications."----but cannot be applied to all serotypes, such as AAV4. pubmed.ncbi.nlm.nih.gov/39944269/
Gut-brain pathways and sites of action of endogenous and exogenous GLP-1 signaling academic.oup.com/endo/article...
February 22, 2025 at 3:04 PM
Gut-brain pathways and sites of action of endogenous and exogenous GLP-1 signaling academic.oup.com/endo/article...
Three sources of myofibroblasts pmc.ncbi.nlm.nih.gov/articles/PMC...
February 22, 2025 at 2:58 PM
Three sources of myofibroblasts pmc.ncbi.nlm.nih.gov/articles/PMC...
library preparation protocols used to study distinct RNA species
February 22, 2025 at 1:42 PM
library preparation protocols used to study distinct RNA species
Keystone: Drug Delivery to the Brain www.keystonesymposia.org/conferences/...
February 22, 2025 at 12:00 AM
Keystone: Drug Delivery to the Brain www.keystonesymposia.org/conferences/...
Choose a right control for immunofluorescence assay
February 19, 2025 at 4:38 PM
Choose a right control for immunofluorescence assay
massively parallel in vivo Perturb-seq screening www.nature.com/articles/s41...
February 19, 2025 at 2:57 AM
massively parallel in vivo Perturb-seq screening www.nature.com/articles/s41...
Improved workflow for Guide-Seq www.biorxiv.org/content/10.1...
February 15, 2025 at 12:00 AM
Improved workflow for Guide-Seq www.biorxiv.org/content/10.1...
Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte? pubmed.ncbi.nlm.nih.gov/39947256/
February 14, 2025 at 2:18 PM
Therapeutic PCSK9 targeting: Inside versus outside the hepatocyte? pubmed.ncbi.nlm.nih.gov/39947256/
Protocol overview for single-cell CRISPR screening in mouse brain.
February 14, 2025 at 4:09 AM
Protocol overview for single-cell CRISPR screening in mouse brain.
Fc Gamma Receptor Polymorphisms in Antibody Therapy: Implications for Bioassay Development to Enhance Product Quality academic.oup.com/abt/advance-...
February 13, 2025 at 2:48 PM
Fc Gamma Receptor Polymorphisms in Antibody Therapy: Implications for Bioassay Development to Enhance Product Quality academic.oup.com/abt/advance-...
Biomolecular condensates: It was RNA all along! dlvr.it/THvRLd
February 12, 2025 at 2:46 PM
Biomolecular condensates: It was RNA all along! dlvr.it/THvRLd
methods explored for drug loading (upper panel) and drug release (lower panel) in protein nanoparticle cages. www.sciencedirect.com/science/arti...
February 11, 2025 at 2:21 PM
methods explored for drug loading (upper panel) and drug release (lower panel) in protein nanoparticle cages. www.sciencedirect.com/science/arti...