Idoia Quintana-Urzainqui
@idoiaeu.bsky.social
EIPOD Fellow @EMBL.Brain EvoDevo. Studying brain development and evolution in sharks and other creatures 🦈 🧠#embryo2014
https://youtu.be/TU7p_34-nmo?si=JlBwcHw1qfU3GvX9
https://youtu.be/TU7p_34-nmo?si=JlBwcHw1qfU3GvX9
Thank you so much Diego! Glad you liked it :)
September 9, 2025 at 4:20 PM
Thank you so much Diego! Glad you liked it :)
Ohhhh. Mil gracias!! Me alegra mucho que lo disfrutes.
September 9, 2025 at 3:21 PM
Ohhhh. Mil gracias!! Me alegra mucho que lo disfrutes.
Thank you Georgios!! 😊 💜 🦈
September 8, 2025 at 11:29 AM
Thank you Georgios!! 😊 💜 🦈
Gracias!!! Qué honor! :)))
September 3, 2025 at 11:51 AM
Gracias!!! Qué honor! :)))
Oh! Qué bien Rodrigo! Qué disfrutes mucho la nueva etapa! :)
September 3, 2025 at 11:21 AM
Oh! Qué bien Rodrigo! Qué disfrutes mucho la nueva etapa! :)
Thank you Cedric!
September 3, 2025 at 11:19 AM
Thank you Cedric!
Thanks Baptiste! :)
September 3, 2025 at 11:18 AM
Thanks Baptiste! :)
Thank you Ali! :)
September 3, 2025 at 10:11 AM
Thank you Ali! :)
Thank you so much Teresa!
September 3, 2025 at 10:10 AM
Thank you so much Teresa!
Thanks also for pointing to that study in cyclids, it is really interesting. But they compare adult to adult, if I am not mistaken
September 3, 2025 at 10:09 AM
Thanks also for pointing to that study in cyclids, it is really interesting. But they compare adult to adult, if I am not mistaken
Good point. Indeed, age and heterochronies can be important players here. Our study includes a window of development equivalent to mouse E12-14, but it looks like our "MP" is a bit less mature than the mouse MP. This can cause the correlations to be lower, not necesarily meaning a lack of homology..
September 3, 2025 at 10:09 AM
Good point. Indeed, age and heterochronies can be important players here. Our study includes a window of development equivalent to mouse E12-14, but it looks like our "MP" is a bit less mature than the mouse MP. This can cause the correlations to be lower, not necesarily meaning a lack of homology..
Gracias Rodrigo! :)
September 3, 2025 at 9:52 AM
Gracias Rodrigo! :)
Thanks to Arendt group: Detlev, Leslie, Tobi, Nico @galicae.bsky.social and Phil. My amazing students @gulceserka.bsky.social, @anaverbanac.bsky.social,Maite and Dori. Huge thanks to the Kaessmann lab for all their support and fruitful discussions @kaessmannlab.bsky.social @evo-and-devo.bsky.social
a man in a suit and tie is giving a thank you sign .
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September 2, 2025 at 5:51 PM
Thanks to Arendt group: Detlev, Leslie, Tobi, Nico @galicae.bsky.social and Phil. My amazing students @gulceserka.bsky.social, @anaverbanac.bsky.social,Maite and Dori. Huge thanks to the Kaessmann lab for all their support and fruitful discussions @kaessmannlab.bsky.social @evo-and-devo.bsky.social
We now have a unique opportunity to keep developing cartilaginous fish models. Throug their study we will be able to explore how these and other features evolved across vertebrates and uncover the molecular mechanisms driving brain evolution. Stay tuned for more discoveries and tool developments!
September 2, 2025 at 5:51 PM
We now have a unique opportunity to keep developing cartilaginous fish models. Throug their study we will be able to explore how these and other features evolved across vertebrates and uncover the molecular mechanisms driving brain evolution. Stay tuned for more discoveries and tool developments!
Our study moved the postulated origin of several developmental pallial features back to the jawed common ancestor. We hypothesize these features likely contributed to the increased complexity of their brains coincident with the emergence of predation.
a stuffed shark is standing in front of a fire
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September 2, 2025 at 5:51 PM
Our study moved the postulated origin of several developmental pallial features back to the jawed common ancestor. We hypothesize these features likely contributed to the increased complexity of their brains coincident with the emergence of predation.
Using the plasmid, we showed that the dorsal pallial area gives rise to a layered structure aligned with the positions of Reelin and CRs. Moreover, this structure corresponds with a complex anatomical region that brings together glutamatergic and GABAergic neurons, likely forming a complex circuitry
September 2, 2025 at 5:51 PM
Using the plasmid, we showed that the dorsal pallial area gives rise to a layered structure aligned with the positions of Reelin and CRs. Moreover, this structure corresponds with a complex anatomical region that brings together glutamatergic and GABAergic neurons, likely forming a complex circuitry
We developed a protocol to label shark neural tissue with a reporter plasmid- First time this is achieved in a Cartilaginous Fish! Impossible without (bluesky-less) Maite Boersig, Isabel Rollán, Dori Torres-Sabino and Rami Reshef. The coolest shark team ever!🦈💙
September 2, 2025 at 5:51 PM
We developed a protocol to label shark neural tissue with a reporter plasmid- First time this is achieved in a Cartilaginous Fish! Impossible without (bluesky-less) Maite Boersig, Isabel Rollán, Dori Torres-Sabino and Rami Reshef. The coolest shark team ever!🦈💙
Even more interesting, their location closely matched where reelin is expressed.
September 2, 2025 at 5:51 PM
Even more interesting, their location closely matched where reelin is expressed.
But where are CRs in the shark brain?
Using HCR we found them emerging from medial pallial regions, spread across the surface of the dorsal and medial pallium and near the olfactory bulb. Really similar to their locations in mammals. Thanks to @anaverbanac.bsky.social for all her HCR work!
Using HCR we found them emerging from medial pallial regions, spread across the surface of the dorsal and medial pallium and near the olfactory bulb. Really similar to their locations in mammals. Thanks to @anaverbanac.bsky.social for all her HCR work!
September 2, 2025 at 5:51 PM
But where are CRs in the shark brain?
Using HCR we found them emerging from medial pallial regions, spread across the surface of the dorsal and medial pallium and near the olfactory bulb. Really similar to their locations in mammals. Thanks to @anaverbanac.bsky.social for all her HCR work!
Using HCR we found them emerging from medial pallial regions, spread across the surface of the dorsal and medial pallium and near the olfactory bulb. Really similar to their locations in mammals. Thanks to @anaverbanac.bsky.social for all her HCR work!
Very timely, beautiful work from Maria Tosches lab @matosches.bsky.social shows CR-like cells (Tp73 positive) in a variety of vertebrates! Supporting their ancient origin. Check it out! www.biorxiv.org/content/10.1...
Evolution of Cajal-Retzius Cells in Vertebrates from an Ancient Class of Tp73+ Neurons
In the developing cerebral cortex, Cajal Retzius (CR) cells are early-born neurons that orchestrate the development of mammalian-specific cortical features. However, this cell type has not been conclu...
www.biorxiv.org
September 2, 2025 at 5:51 PM
Very timely, beautiful work from Maria Tosches lab @matosches.bsky.social shows CR-like cells (Tp73 positive) in a variety of vertebrates! Supporting their ancient origin. Check it out! www.biorxiv.org/content/10.1...
Key question : are shark CR cells homologous to those of mammals? Our various cross-species comparisons suggest they are. Indeed, it was the only cell type with a clear one-to-one match across the three species—supporting an ancient origin of CR cells at least in the stem of al jawed vertebrates.
September 2, 2025 at 5:51 PM
Key question : are shark CR cells homologous to those of mammals? Our various cross-species comparisons suggest they are. Indeed, it was the only cell type with a clear one-to-one match across the three species—supporting an ancient origin of CR cells at least in the stem of al jawed vertebrates.
Cajal-Retzius cells—first described by Ramón y Cajal and Gustaf Retzius—are a peculiar developmental type essential for neocortex development. They spread through the outter-most cortical layer, they express reelin, and guide the formation of the six neocortical layers, among other key roles.
September 2, 2025 at 5:51 PM
Cajal-Retzius cells—first described by Ramón y Cajal and Gustaf Retzius—are a peculiar developmental type essential for neocortex development. They spread through the outter-most cortical layer, they express reelin, and guide the formation of the six neocortical layers, among other key roles.