Center for Molecular Integrative Neuroresilience
@icahncmin.bsky.social
Creating a culture of innovation that emphasizes creativity, disruptive thinking, and interdisciplinary collaboration to understand and promote neuroresilience.
Researchers at Kindai University have discovered that oral administration of arginine, a naturally occurring amino acid, can suppress amyloid β (Aβ) aggregation & alleviate neurological symptoms in animal models of #Alzheimers. In Neurochemistry International ➡️ www.sciencedirect.com/science/arti...
November 25, 2025 at 2:19 PM
Researchers at Kindai University have discovered that oral administration of arginine, a naturally occurring amino acid, can suppress amyloid β (Aβ) aggregation & alleviate neurological symptoms in animal models of #Alzheimers. In Neurochemistry International ➡️ www.sciencedirect.com/science/arti...
Researchers Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Benjamin Deneen, et al. @bcmhouston.bsky.social discovered natural mechanism that clears existing #Amyloid plaques in brains of mouse models of #Alzheimers & preserves cognitive function. Nature Neuroscience 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 24, 2025 at 2:45 PM
Researchers Dong-Joo Choi, Sanjana Murali, Wookbong Kwon, Benjamin Deneen, et al. @bcmhouston.bsky.social discovered natural mechanism that clears existing #Amyloid plaques in brains of mouse models of #Alzheimers & preserves cognitive function. Nature Neuroscience 👉
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A MUST READ! Zaven Khachaturian offers a unique perspective & terrific account of the history of Alzheimer Movement in the United States as well as the origins & future of Alzheimer's Disease Research Centers (ADRC). @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
November 21, 2025 at 2:44 PM
A MUST READ! Zaven Khachaturian offers a unique perspective & terrific account of the history of Alzheimer Movement in the United States as well as the origins & future of Alzheimer's Disease Research Centers (ADRC). @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
People w/ lower incomes & people from racial & ethnic historically underrepresented groups in clinical studies are more likely to have modifiable risk factors for #Dementia, factors that could be changed to lower their risk. Learn More @greenjournal.bsky.social 👉 www.neurology.org/doi/10.1212/...
Income, Race-Ethnicity, and Dementia Risk Factors in the United States | Neurology
ObjectivesTo determine population attributable fractions (PAFs) of modifiable dementia risk
factors by income, and independent and interactive associations of race-ethnicity
and income with each risk ...
www.neurology.org
November 20, 2025 at 6:58 PM
People w/ lower incomes & people from racial & ethnic historically underrepresented groups in clinical studies are more likely to have modifiable risk factors for #Dementia, factors that could be changed to lower their risk. Learn More @greenjournal.bsky.social 👉 www.neurology.org/doi/10.1212/...
Researchers Tomomi Takahashi, Rei Kurita, et al. at Tokyo Metropolitan University have turned to concepts from polymer physics to better understand a central feature of #Alzheimers: the formation of tau protein fibrils. Learn More @elsevierconnect.bsky.social 👉 www.sciencedirect.com/science/arti...
November 17, 2025 at 3:56 PM
Researchers Tomomi Takahashi, Rei Kurita, et al. at Tokyo Metropolitan University have turned to concepts from polymer physics to better understand a central feature of #Alzheimers: the formation of tau protein fibrils. Learn More @elsevierconnect.bsky.social 👉 www.sciencedirect.com/science/arti...
Once again, congratulations to @mountsinainyc.bsky.social's Pinar Ayata, Jessica Crowle, Matthew Challman, John Crary, Alison Goate, Anne Schaefer, et al., as well as, all of the contributing researchers from other institutions! Very exciting work.
PRESS RELEASE! Building on the pioneering work of Dr. Alison Goate, an int'l team, led by @mountsinainyc.bsky.social's Anne Schaefer, ID'd a distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers 👉 www.mountsinai.org/about/newsro...
November 15, 2025 at 2:36 PM
Once again, congratulations to @mountsinainyc.bsky.social's Pinar Ayata, Jessica Crowle, Matthew Challman, John Crary, Alison Goate, Anne Schaefer, et al., as well as, all of the contributing researchers from other institutions! Very exciting work.
While exact causes of diseases like #Alzheimers & #Dementia are largely unknown, researchers have been able to ID a key characteristic in affected brains: reduced blood flow. Here, Patrick Drew, et al. at Penn Sate build upon this understanding. @elife.bsky.social 👉 elifesciences.org/articles/105...
November 13, 2025 at 1:49 PM
While exact causes of diseases like #Alzheimers & #Dementia are largely unknown, researchers have been able to ID a key characteristic in affected brains: reduced blood flow. Here, Patrick Drew, et al. at Penn Sate build upon this understanding. @elife.bsky.social 👉 elifesciences.org/articles/105...
What an incredible day! THANK YOU SO MUCH to the organizers of EICMMHD 2025. Organizing such an outstanding conference is a rare & exciting accomplishment. The reaction to my presentation truly exceeded my expectations! Thank you to my amazing colleagues for making this session such a huge success.
November 12, 2025 at 3:21 PM
What an incredible day! THANK YOU SO MUCH to the organizers of EICMMHD 2025. Organizing such an outstanding conference is a rare & exciting accomplishment. The reaction to my presentation truly exceeded my expectations! Thank you to my amazing colleagues for making this session such a huge success.
🚀 TOMORROW! I am thrilled to present at the 6th Egyptian Intl. Conf. on #Microbiota & #Microbiome in Health & Disease. Futhermore, I am absolutely delighted to have been asked to Chair session 2 on Day 1. Learn More 👉 efmsa.org Check Out Agenda 👉 www.efmsa.org/agenda/2025
November 11, 2025 at 3:40 PM
🚀 TOMORROW! I am thrilled to present at the 6th Egyptian Intl. Conf. on #Microbiota & #Microbiome in Health & Disease. Futhermore, I am absolutely delighted to have been asked to Chair session 2 on Day 1. Learn More 👉 efmsa.org Check Out Agenda 👉 www.efmsa.org/agenda/2025
🇺🇸 Honoring Veterans in November 🇺🇸
As a proud @deptvetaffairs.bsky.social federal employee serving at the #VABronx, I am humbled by the unselfish sacrifice veterans make & am proud of the work my colleagues do. To our #Veterans, #MilitaryFamilies & #WarriorCaregivers, THANK YOU for your service!
As a proud @deptvetaffairs.bsky.social federal employee serving at the #VABronx, I am humbled by the unselfish sacrifice veterans make & am proud of the work my colleagues do. To our #Veterans, #MilitaryFamilies & #WarriorCaregivers, THANK YOU for your service!
November 10, 2025 at 10:25 PM
🇺🇸 Honoring Veterans in November 🇺🇸
As a proud @deptvetaffairs.bsky.social federal employee serving at the #VABronx, I am humbled by the unselfish sacrifice veterans make & am proud of the work my colleagues do. To our #Veterans, #MilitaryFamilies & #WarriorCaregivers, THANK YOU for your service!
As a proud @deptvetaffairs.bsky.social federal employee serving at the #VABronx, I am humbled by the unselfish sacrifice veterans make & am proud of the work my colleagues do. To our #Veterans, #MilitaryFamilies & #WarriorCaregivers, THANK YOU for your service!
Loss of social cognition memory impairs #Alzheimers patients to recognize family, friends, & caregivers. Harald Sontheimer, et al. investigated role of perineuronal nets in AD-associated social memory impairments. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
November 10, 2025 at 9:08 PM
Loss of social cognition memory impairs #Alzheimers patients to recognize family, friends, & caregivers. Harald Sontheimer, et al. investigated role of perineuronal nets in AD-associated social memory impairments. @alzdemjournals.bsky.social 👉 alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Weill Cornell's Daniel Barnett, Till Zimmer, Caroline Booraem, et al. uncovered how free radicals from astrocyte mitochondria can fuel #Dementia revealing potential breakthrough for treating diseases like #Alzheimers & #FrontotemporalDementia. In Nature Metabolism ➡️ www.nature.com/articles/s42...
November 7, 2025 at 7:40 PM
Weill Cornell's Daniel Barnett, Till Zimmer, Caroline Booraem, et al. uncovered how free radicals from astrocyte mitochondria can fuel #Dementia revealing potential breakthrough for treating diseases like #Alzheimers & #FrontotemporalDementia. In Nature Metabolism ➡️ www.nature.com/articles/s42...
EXCITING WORK! Congratulations to the Icahn School of Medicine at Mount Sinai’s Pinar Ayata, Jessica Crowley, Matthew Challman, John Crary, Alison Goate, Anne Schaefer, et al., as well as contributing researchers from other institutions!
Read FULL STUDY @nature.com
👉 www.nature.com/articles/s41...
Read FULL STUDY @nature.com
👉 www.nature.com/articles/s41...
November 7, 2025 at 12:29 AM
EXCITING WORK! Congratulations to the Icahn School of Medicine at Mount Sinai’s Pinar Ayata, Jessica Crowley, Matthew Challman, John Crary, Alison Goate, Anne Schaefer, et al., as well as contributing researchers from other institutions!
Read FULL STUDY @nature.com
👉 www.nature.com/articles/s41...
Read FULL STUDY @nature.com
👉 www.nature.com/articles/s41...
🚀 ONE WEEK AWAY! I am thrilled to present at the 6th Egyptian Intl. Conf. on #Microbiota & #Microbiome in Health & Disease. Futhermore, I am absolutely delighted to have been asked to Chair session 2 on Day 1. Learn More 👉 efmsa.org Check Out Agenda 👉 www.efmsa.org/agenda/2025
November 5, 2025 at 4:03 PM
🚀 ONE WEEK AWAY! I am thrilled to present at the 6th Egyptian Intl. Conf. on #Microbiota & #Microbiome in Health & Disease. Futhermore, I am absolutely delighted to have been asked to Chair session 2 on Day 1. Learn More 👉 efmsa.org Check Out Agenda 👉 www.efmsa.org/agenda/2025
@massgeneralbrigham.bsky.social researchers Wai-Ying Wendy Yau, Dylan Kirn, Jennifer Rabin, et al. found that increasing your steps by even a little bit may help slow down progression of #Alzheimers among people at heightened risk. Full Study in Nature Medicine 👉 www.nature.com/articles/s41...
November 4, 2025 at 12:55 AM
@massgeneralbrigham.bsky.social researchers Wai-Ying Wendy Yau, Dylan Kirn, Jennifer Rabin, et al. found that increasing your steps by even a little bit may help slow down progression of #Alzheimers among people at heightened risk. Full Study in Nature Medicine 👉 www.nature.com/articles/s41...
How can flavanols influence brain function & nervous system when so little of them are absorbed? Researchers at the Shibaura Institute of Technology investigated how #Flavanols affect the nervous system through sensory stimulation. @elsevierconnect.bsky.social 👉 www.sciencedirect.com/science/arti...
Astringent flavanol fires the locus-noradrenergic system, regulating neurobehavior and autonomic nerves
Astringency is a characteristic exhibited by only a limited number of polyphenolic compounds which show high electrochemical activity and are suscepti…
www.sciencedirect.com
November 3, 2025 at 3:52 PM
How can flavanols influence brain function & nervous system when so little of them are absorbed? Researchers at the Shibaura Institute of Technology investigated how #Flavanols affect the nervous system through sensory stimulation. @elsevierconnect.bsky.social 👉 www.sciencedirect.com/science/arti...
TERRIFIC PAPER! University of Tehran's Ameneh Rezayof, et al. investigated role of #NitricOxide system w/in dorsomedial nucleus of thalamus in regulating memory performance & cortical electrophysiological activity in rat model of #AD @elsevierconnect.bsky.social www.sciencedirect.com/science/arti...
Modulation of the mediodorsal thalamic nitric oxide system ameliorated amnesia and medial prefrontal abnormal network activity in a streptozotocin-induced rat model of Alzheimer's disease
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by amnesia and neuronal network dysfunction. Given that the mediodo…
www.sciencedirect.com
November 1, 2025 at 5:42 PM
TERRIFIC PAPER! University of Tehran's Ameneh Rezayof, et al. investigated role of #NitricOxide system w/in dorsomedial nucleus of thalamus in regulating memory performance & cortical electrophysiological activity in rat model of #AD @elsevierconnect.bsky.social www.sciencedirect.com/science/arti...
Very Interesting Paper ➡️ Findings by Chiara Moretti, Magnus Simrén, Fredrik Bäckhed, et al. suggest that specific members of the human gut #Microbiota synthesize bioactive #Serotonin that can contribute to gut health. @cp-cellreports.bsky.social 👉 www.sciencedirect.com/science/arti...
Identification of human gut bacteria that produce bioactive serotonin and promote colonic innervation
The gut microbiota regulates host intestinal serotonin synthesis, thereby promoting the development and maintenance of the enteric nervous system, whi…
www.sciencedirect.com
October 31, 2025 at 10:59 PM
Very Interesting Paper ➡️ Findings by Chiara Moretti, Magnus Simrén, Fredrik Bäckhed, et al. suggest that specific members of the human gut #Microbiota synthesize bioactive #Serotonin that can contribute to gut health. @cp-cellreports.bsky.social 👉 www.sciencedirect.com/science/arti...
Researchers Junyang Chen, Pan Xiang, Qiyong Gong, Xiaohe Tian, Giuseppe Battaglia, et al. report a nanotechnology approach that reverses #AlzheimersDisease in mouse models.
Learn More in Signal Transduction and Targeted Therapy @natureportfolio.nature.com
www.nature.com/articles/s41...
Learn More in Signal Transduction and Targeted Therapy @natureportfolio.nature.com
www.nature.com/articles/s41...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
www.nature.com
October 30, 2025 at 7:20 PM
Researchers Junyang Chen, Pan Xiang, Qiyong Gong, Xiaohe Tian, Giuseppe Battaglia, et al. report a nanotechnology approach that reverses #AlzheimersDisease in mouse models.
Learn More in Signal Transduction and Targeted Therapy @natureportfolio.nature.com
www.nature.com/articles/s41...
Learn More in Signal Transduction and Targeted Therapy @natureportfolio.nature.com
www.nature.com/articles/s41...
Research by Hiro Furukawa, et al. reveals how NMDA receptors control learning, memory & neuron survival. Discovery could lead to therapies that precisely modulate brain signaling to protect against #Alzheimers #Stroke & other #NeurodegenerativeDisorders. @nature.com 👉 www.nature.com/articles/s41...
Mechanism of conductance control and neurosteroid binding in NMDA receptors - Nature
Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.
www.nature.com
October 29, 2025 at 6:20 PM
Research by Hiro Furukawa, et al. reveals how NMDA receptors control learning, memory & neuron survival. Discovery could lead to therapies that precisely modulate brain signaling to protect against #Alzheimers #Stroke & other #NeurodegenerativeDisorders. @nature.com 👉 www.nature.com/articles/s41...
🚀 TWO WEEKS AWAY! I am thrilled to be presenting at the 6th Egyptian Intl. Conference on #Microbiota & #Microbiome in Health & Disease. EFMSA's mission is to advance the field of microbiome science & its applications. It is an honor to have been invited to speak! Learn More 👉 www.efmsa.org
October 28, 2025 at 7:57 PM
🚀 TWO WEEKS AWAY! I am thrilled to be presenting at the 6th Egyptian Intl. Conference on #Microbiota & #Microbiome in Health & Disease. EFMSA's mission is to advance the field of microbiome science & its applications. It is an honor to have been invited to speak! Learn More 👉 www.efmsa.org
Researchers Pat Sheehan, et al. @washumedicine.bsky.social have shown in mice that circadian rhythms w/in particular brain cells are disrupted in #Alzheimers in ways that change how & when hundreds of genes regulate key functions in the brain. Nature Neuroscience www.nature.com/articles/s41...
A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging - Nature Neuroscience
Sheehan et al. have characterized the circadian translatomes of astrocytes and microglia in the mouse cortex in the context of amyloid pathology or aging, revealing cell- and disease-specific reprogra...
www.nature.com
October 27, 2025 at 2:01 PM
Researchers Pat Sheehan, et al. @washumedicine.bsky.social have shown in mice that circadian rhythms w/in particular brain cells are disrupted in #Alzheimers in ways that change how & when hundreds of genes regulate key functions in the brain. Nature Neuroscience www.nature.com/articles/s41...
The 57th Brazilian Congress of Pharmacology and Experimental Therapeutics could not have been more exciting. Amazingly and serendipitously, I was able to meet up with the University Sao Paolo's Prof. Jose Belizario, an old friend. An amazing experience, full of nostalgia and new memories.
October 24, 2025 at 6:28 PM
The 57th Brazilian Congress of Pharmacology and Experimental Therapeutics could not have been more exciting. Amazingly and serendipitously, I was able to meet up with the University Sao Paolo's Prof. Jose Belizario, an old friend. An amazing experience, full of nostalgia and new memories.
Yesterday, October 23rd, I had privilege of presenting at the 57th Brazilian Congress of Pharmacology and Experimental Therapeutics at USP - Universidade de São Paulo @usponline. What a FANTASTIC EXPERIENCE! Thank you so much to the organizers for an incredible event.
October 24, 2025 at 5:55 PM
Yesterday, October 23rd, I had privilege of presenting at the 57th Brazilian Congress of Pharmacology and Experimental Therapeutics at USP - Universidade de São Paulo @usponline. What a FANTASTIC EXPERIENCE! Thank you so much to the organizers for an incredible event.
Study by Hugh Markus, et al. at Cambridge found impaired movement of #CerebrospinalFluid predicted #Dementia risk later in life among 40,000 adults recruited to the @ukbiobank.bsky.social. @alzdemjournals.bsky.social @alzassociation.bsky.social
➡️ alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
➡️ alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
October 23, 2025 at 7:59 PM
Study by Hugh Markus, et al. at Cambridge found impaired movement of #CerebrospinalFluid predicted #Dementia risk later in life among 40,000 adults recruited to the @ukbiobank.bsky.social. @alzdemjournals.bsky.social @alzassociation.bsky.social
➡️ alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
➡️ alz-journals.onlinelibrary.wiley.com/doi/10.1002/...