Ian Cockburn
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iancockburn.bsky.social
Ian Cockburn
@iancockburn.bsky.social
230 followers 53 following 1 posts
Immunologist @ANU | Here for the Science and to know what everyone is up to
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Reposted by Ian Cockburn
labwaggoner.bsky.social
B cells targeting parasites capture spatially linked antigens to secure T cell help @sciimmunology.bsky.social
www.science.org/doi/10.1126/...
November 7, 2025 at 9:37 PM
Reposted by Ian Cockburn
immunoeditor.bsky.social
Nov issue of #Science #Immunology out now!

This week: exTH17 cells sustain #IL17 –independent rheumatoid #arthritis; CXCR4+ mesodermal progenitors → rostral blood vessels, prodefinitive hematopoiesis, & postnatal tissue #macrophages; & how #Bcells acquire antigens from #parasites!

scim.ag/4qQA6Q6
ONLINE COVERB Cell Help Measures Up Against Parasites. How B cells acquire antigens from large pathogens, including single-celled parasites, to support T cell–driven humoral responses is not well understood. Gao et al. used Ighg2A10 B cells specific for the surface Plasmodium falciparum circumsporozoite protein (PfCSP) to examine the interaction between B cells and Plasmodium berghei sporozoites engineered to express PfCSP. Ighg2A10 B cells could internalize and present cognate and bystander surface antigens, which resulted in both intramolecular and intermolecular CD4 T cell help. This help either suppressed or supported protective B cell responses depending on whether the CD4 T cells recognized cytosolic or surface sporozoite antigens. This month’s cover is a pseudocolored and digitally altered scanning electron microscopy (SEM) micrograph of Plasmodium sporozoites (pale purple) attached to Ighg2A10 B cells (bright pink) at one end. Martin Oeggerli (Micronaut) 2025, with Xin Gao and Ian Cockburn, The John Curtin School of Medicine Research, Australian National University
November 7, 2025 at 10:19 PM
iancockburn.bsky.social
To get the ball rolling here on Bsky I'll post this recent preprint that I never posted on X because... you know... ick.
We find that B cells take bites out of parasites to obtain antigens for presentation to T cells.
www.biorxiv.org/content/10.1...
B cells targeting parasites capture spatially linked antigens to secure T cell help
Our understanding of T-cell-dependent humoral responses has been largely shaped by studies involving model antigens such as recombinant proteins and viruses [1][1],[2][2]. In these contexts, B cells i...
www.biorxiv.org
November 21, 2024 at 9:49 PM