Hotte
@hottekoeln.bsky.social
Mitochondrial Stress, Melatonin, and Neurodegenerative Diseases: New Nanopharmacological Approaches
www.techscience.com/biocell/v49n...
www.techscience.com/biocell/v49n...
Mitochondrial Stress, Melatonin, and Neurodegenerative Diseases: New Nanopharmacological Approaches
Neurodegenerative diseases (NDs) such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), and amyotrophic lateral sclerosis (ALS) are characterized by progressive neurona...
www.techscience.com
December 27, 2025 at 6:30 AM
Mitochondrial Stress, Melatonin, and Neurodegenerative Diseases: New Nanopharmacological Approaches
www.techscience.com/biocell/v49n...
www.techscience.com/biocell/v49n...
Liquid–Liquid Phase Separation of AR Orchestrated by Melatonin Sensitizes Prostate Cancer to Ferroptosis Via MCM5/NRF2 Axis Collapse
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Liquid–Liquid Phase Separation of AR Orchestrated by Melatonin Sensitizes Prostate Cancer to Ferroptosis Via MCM5/NRF2 Axis Collapse
The treatment of prostate cancer (PCa) remains challenging, and while melatonin (MEL) has demonstrated therapeutic potential, its precise mechanisms require further elucidation. Through integrated in...
onlinelibrary.wiley.com
October 30, 2025 at 2:44 AM
Liquid–Liquid Phase Separation of AR Orchestrated by Melatonin Sensitizes Prostate Cancer to Ferroptosis Via MCM5/NRF2 Axis Collapse
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Vitamin D May Increase the Number of CD4-CD8+ NKT-like Cells in Humans—A Novel Insight into Potential Immunomodulatory Action
www.mdpi.com/2072-6643/17...
www.mdpi.com/2072-6643/17...
www.mdpi.com
October 15, 2025 at 11:00 AM
Vitamin D May Increase the Number of CD4-CD8+ NKT-like Cells in Humans—A Novel Insight into Potential Immunomodulatory Action
www.mdpi.com/2072-6643/17...
www.mdpi.com/2072-6643/17...
Vitamin D as an Immune Modulator in Systemic Lupus Erythematosus: A Narrative Review
www.mdpi.com/2075-1729/15...
www.mdpi.com/2075-1729/15...
www.mdpi.com
October 12, 2025 at 1:55 AM
Vitamin D as an Immune Modulator in Systemic Lupus Erythematosus: A Narrative Review
www.mdpi.com/2075-1729/15...
www.mdpi.com/2075-1729/15...
Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast - Communications Biology
A study using fission yeast reveals that rapalink-1 extends lifespan and identifies new anti-ageing proteins, including all agmatinase enzymes. Agmatinases are shown to modulate growth through the regulation of the target of rapamycin signalling pathway.
www.nature.com
October 10, 2025 at 4:26 AM
Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Microplastics found to change gut microbiome in first human-sample study
medicalxpress.com/news/2025-10...
medicalxpress.com/news/2025-10...
Microplastics found to change gut microbiome in first human-sample study
New research presented at UEG Week 2025 shows that microplastics—plastic particles smaller than 5 mm commonly found in the environment—can alter the human gut microbiome, with some changes resembling ...
medicalxpress.com
October 8, 2025 at 12:17 AM
Microplastics found to change gut microbiome in first human-sample study
medicalxpress.com/news/2025-10...
medicalxpress.com/news/2025-10...
Sugar Restriction in the First 1000 Days after Conception and Long-Term Respiratory Health: A Quasi-experiment Study
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Sugar Restriction in the First 1000 Days after Conception and Long-Term Respiratory Health: A Quasi-experiment Study
High sugar intake during the first 1,000 days after conception is common and may impact lifelong respiratory health. While early-life sugar exposure h…
www.sciencedirect.com
October 7, 2025 at 6:37 AM
Sugar Restriction in the First 1000 Days after Conception and Long-Term Respiratory Health: A Quasi-experiment Study
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain
Microvascular circulation in the brain is often impaired in connection with the loss of pericytes in old age. The neurotrophic factor BDNF also decreases in the aging brain. We hypothesized that BDNF ...
www.biorxiv.org
October 7, 2025 at 6:32 AM
Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
www.nature.com
October 7, 2025 at 2:22 AM
Rapid amyloid-β clearance and cognitive recovery through multivalent modulation of blood–brain barrier transport
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Cardiovascular protective properties of the natural product eugenol
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Cardiovascular protective properties of the natural product eugenol
Medicinal herbs have long been used in traditional medicine and their multi-featured bioactivities against the pathophysiology of chronic diseases are…
www.sciencedirect.com
October 4, 2025 at 11:13 AM
Cardiovascular protective properties of the natural product eugenol
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
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Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial
pubmed.ncbi.nlm.nih.gov/40826930/
Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial
pubmed.ncbi.nlm.nih.gov/40826930/
Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial - PubMed
JOURNAL/mgres/04.03/01612956-202606000-00002/figure1/v/2025-08-18T154854Z/r/image-tiff Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, ...
pubmed.ncbi.nlm.nih.gov
October 4, 2025 at 10:41 AM
,
Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial
pubmed.ncbi.nlm.nih.gov/40826930/
Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial
pubmed.ncbi.nlm.nih.gov/40826930/
The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis
The same phosphatase controls birth and death of mitochondria.
www.science.org
October 4, 2025 at 3:12 AM
The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model
As life expectancy continues to rise, addressing aging and age-related diseases becomes crucial for maintaining a healthy lifestyle. Advanced glycatio…
www.sciencedirect.com
October 2, 2025 at 2:22 AM
Extracellular matrix glycation epigenetically regulates brain aging and neurodegeneration in the in vitro aged neurovascular model
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease
pubmed.ncbi.nlm.nih.gov/40959937/
pubmed.ncbi.nlm.nih.gov/40959937/
Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease - PubMed
Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders, characterized by a progressive decline in cognitive function. Increasing evidence indicates that alpha-ketoglutarate ...
pubmed.ncbi.nlm.nih.gov
September 18, 2025 at 12:06 AM
Alpha-Ketoglutarate Ameliorates Synaptic Plasticity Deficits in APP/PS1 Mice Model of Alzheimer's Disease
pubmed.ncbi.nlm.nih.gov/40959937/
pubmed.ncbi.nlm.nih.gov/40959937/
Blueberry Anthocyanins Ameliorate Hepatic Dysfunction in High-Fat Diet-Fed Mice: Association with Altered Gut Microbiota and Bile Acid Metabolism
www.mdpi.com/2304-8158/14...
www.mdpi.com/2304-8158/14...
www.mdpi.com
September 11, 2025 at 12:54 AM
Blueberry Anthocyanins Ameliorate Hepatic Dysfunction in High-Fat Diet-Fed Mice: Association with Altered Gut Microbiota and Bile Acid Metabolism
www.mdpi.com/2304-8158/14...
www.mdpi.com/2304-8158/14...
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral organoids
pubmed.ncbi.nlm.nih.gov/40913913/?fb...
pubmed.ncbi.nlm.nih.gov/40913913/?fb...
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral organoids - PubMed
Alzheimer's disease (AD) is marked by amyloid-beta (Aβ) plaque buildup, tau hyperphosphorylation, neuroinflammation, neuronal loss, and impaired adult hippocampal neurogenesis (AHN). Taurine has shown...
pubmed.ncbi.nlm.nih.gov
September 8, 2025 at 11:47 PM
Taurine suppresses Aβ aggregation and attenuates Alzheimer's disease pathologies in 5XFAD mice and patient-derived cerebral organoids
pubmed.ncbi.nlm.nih.gov/40913913/?fb...
pubmed.ncbi.nlm.nih.gov/40913913/?fb...
The Anti-Inflammatory Actions of Soluble Klotho in Brain Aging and Its Main Associated Diseases
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
www.mdpi.com
September 4, 2025 at 5:04 AM
The Anti-Inflammatory Actions of Soluble Klotho in Brain Aging and Its Main Associated Diseases
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
www.mdpi.com
September 4, 2025 at 4:57 AM
Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction
www.mdpi.com/1422-0067/26...
www.mdpi.com/1422-0067/26...
Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis
www.mdpi.com/2227-9059/12...
www.mdpi.com/2227-9059/12...
www.mdpi.com
September 4, 2025 at 4:48 AM
Eugenol: A Potential Modulator of Human Platelet Activation and Mouse Mesenteric Vascular Thrombosis via an Innovative cPLA2-NF-κB Signaling Axis
www.mdpi.com/2227-9059/12...
www.mdpi.com/2227-9059/12...
Electromodulation of human monocyte-derived macrophages drives a regenerative phenotype and impedes inflammation
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Electromodulation of human monocyte-derived macrophages drives a regenerative phenotype and impedes inflammation
O’Rourke et al. demonstrate that external delivery of electrical stimulation regulates
the function of innate immune cells, macrophages, to favor tissue repair and regeneration.
These findings are rel...
www.cell.com
September 3, 2025 at 12:41 AM
Electromodulation of human monocyte-derived macrophages drives a regenerative phenotype and impedes inflammation
www.cell.com/cell-reports...
www.cell.com/cell-reports...
Targeting immunosenescence and inflammaging: advancing longevity research
www.nature.com/articles/s12...
www.nature.com/articles/s12...
Targeting immunosenescence and inflammaging: advancing longevity research - Experimental & Molecular Medicine
Aging affects our immune system, leading to a decline in its function and increased inflammation, known as immunosenescence and inflammaging. Researchers have studied ways to improve immune health and...
www.nature.com
September 2, 2025 at 11:06 AM
Targeting immunosenescence and inflammaging: advancing longevity research
www.nature.com/articles/s12...
www.nature.com/articles/s12...
Evaluating the nonlinear effects of sleep duration on biological aging across phenotypic, genomic, and epigenomic data
www.aging-us.com/article/2063...
www.aging-us.com/article/2063...
Evaluating the nonlinear effects of sleep duration on biological aging across phenotypic, genomic, and epigenomic data | Aging
Aging | doi:10.18632/aging.206306. Xueyao Wu, Xunying Zhao, Aaron Ge, Zhitong Han, Can Hou, Yu Hao, Jinyu Xiao, Mengyu Fan, Stephen Burgess, Jiayuan Li, Xia Jiang
www.aging-us.com
September 2, 2025 at 1:19 AM
Evaluating the nonlinear effects of sleep duration on biological aging across phenotypic, genomic, and epigenomic data
www.aging-us.com/article/2063...
www.aging-us.com/article/2063...