Hopfner Lab
@hopfnerlab.bsky.social
Structural biology on DNA repair, chromatin remodelling and innate immunity. Located at the Gene Center of the LMU in Munich.
https://www.genzentrum.uni-muenchen.de/research-groups/hopfner/index.html
https://www.genzentrum.uni-muenchen.de/research-groups/hopfner/index.html
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
September 18, 2025 at 4:09 PM
Thrilled that our work is now finally out in Nature Comms!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
rdcu.be/eG3vP
We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres.
Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
August 27, 2025 at 12:54 PM
Feeling recharged after our lab retreat in Obergurgl 🌞⛰️
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Great hikes, perfect weather, motivating talks from @oliveiramann.bsky.social, Liudmila Andreeva and lots of inspiring discussions. Big thanks for the warm hospitality!
Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
December 3, 2024 at 1:00 PM
Hello, Bluesky!
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie
To kick things off here, we’re excited to share: The SLFN11 story continues! We combined cryo-EM and biochemical assays to explain how phosphorylation regulates SLFN11´s tRNA cleavage and ssDNA binding activities.
Check out our new paper here www.nature.com/articles/s41... + movie