Matt Holt
@holtjma.bsky.social
Staff scientist at @PacBio; formerly @hudsonalpha; avid gamer; opinions are my own
I just try to avoid major deviations from norms, even if those deviations are *technically* in spec. There’s usually no reward, just a high risk of a bunch of user issues/complaints distracting from the fun parts of what we do.
November 7, 2025 at 2:07 AM
I just try to avoid major deviations from norms, even if those deviations are *technically* in spec. There’s usually no reward, just a high risk of a bunch of user issues/complaints distracting from the fun parts of what we do.
This sounds like the kind of thing that would break a lot of parsers, I guess the current VCF spec doesn’t work for some reason?
November 7, 2025 at 12:31 AM
This sounds like the kind of thing that would break a lot of parsers, I guess the current VCF spec doesn’t work for some reason?
TotK is the obvious extension. If you like Mario Odyssey, DK Bananza is somewhat similar to both (and kid friendly if that matters). It’s hard to find a game with adventure/story/cinematics + open world + puzzles/crafting, which is part of why BotW was so awesome!
November 3, 2025 at 12:58 PM
TotK is the obvious extension. If you like Mario Odyssey, DK Bananza is somewhat similar to both (and kid friendly if that matters). It’s hard to find a game with adventure/story/cinematics + open world + puzzles/crafting, which is part of why BotW was so awesome!
It’s challenging as well, the difference in AI slop and human sloppiness is hard to distinguish. I didn’t want to name the preprint because it could just be poor writing and inattention to detail, hard to say.
October 20, 2025 at 4:28 PM
It’s challenging as well, the difference in AI slop and human sloppiness is hard to distinguish. I didn’t want to name the preprint because it could just be poor writing and inattention to detail, hard to say.
Reposted by Matt Holt
Paraviewer creates easy-to-use review websites from Paraphase output. Try these demos!
WGS data: pacificbiosciences.github.io/ParaviewerWG...
PureTarget data: pacificbiosciences.github.io/ParaviewerPT...
WGS data: pacificbiosciences.github.io/ParaviewerWG...
PureTarget data: pacificbiosciences.github.io/ParaviewerPT...
Paraviewer
pacificbiosciences.github.io
October 15, 2025 at 2:59 PM
Paraviewer creates easy-to-use review websites from Paraphase output. Try these demos!
WGS data: pacificbiosciences.github.io/ParaviewerWG...
PureTarget data: pacificbiosciences.github.io/ParaviewerPT...
WGS data: pacificbiosciences.github.io/ParaviewerWG...
PureTarget data: pacificbiosciences.github.io/ParaviewerPT...