Matt Holt
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holtjma.bsky.social
Matt Holt
@holtjma.bsky.social
Staff scientist at @PacBio; formerly @hudsonalpha; avid gamer; opinions are my own
I just try to avoid major deviations from norms, even if those deviations are *technically* in spec. There’s usually no reward, just a high risk of a bunch of user issues/complaints distracting from the fun parts of what we do.
November 7, 2025 at 2:07 AM
This sounds like the kind of thing that would break a lot of parsers, I guess the current VCF spec doesn’t work for some reason?
November 7, 2025 at 12:31 AM
Poshanka!
November 5, 2025 at 1:34 AM
TotK is the obvious extension. If you like Mario Odyssey, DK Bananza is somewhat similar to both (and kid friendly if that matters). It’s hard to find a game with adventure/story/cinematics + open world + puzzles/crafting, which is part of why BotW was so awesome!
November 3, 2025 at 12:58 PM
It’s challenging as well, the difference in AI slop and human sloppiness is hard to distinguish. I didn’t want to name the preprint because it could just be poor writing and inattention to detail, hard to say.
October 20, 2025 at 4:28 PM
Reposted by Matt Holt
Paraviewer creates easy-to-use review websites from Paraphase output. Try these demos!

WGS data: pacificbiosciences.github.io/ParaviewerWG...

PureTarget data: pacificbiosciences.github.io/ParaviewerPT...
Paraviewer
pacificbiosciences.github.io
October 15, 2025 at 2:59 PM