Holger Heyn
@hoheyn.bsky.social
Scientist. Single Cell Genomics Group Leader at CNAG. Co-founder & CSO at Omniscope. ICREA Professor.
Reposted by Holger Heyn
📢New paper out in Oncogene!
➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)
📎 www.nature.com/articles/s41...
➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)
📎 www.nature.com/articles/s41...
Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes - Oncogene
Oncogene - Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes
www.nature.com
April 3, 2025 at 7:20 AM
📢New paper out in Oncogene!
➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)
📎 www.nature.com/articles/s41...
➡️'Transcriptional reprogramming triggered by neonatal UV radiation or Lkb1 loss prevents BRAFV600E-induced growth arrest in melanocytes', with the collaboration of @paulanietog.bsky.social, Ginevra Caratù and @hoheyn.bsky.social (CNAG)
📎 www.nature.com/articles/s41...
Reposted by Holger Heyn
🚀New research published in @naturecomms.bsky.social!
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG
📎 www.nature.com/articles/s41...
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG
📎 www.nature.com/articles/s41...
Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer - Nature Communications
‘T cell engagers promote antitumor immunity, but how macrophage modulates this activity in tumor is still unclear. Here the authors show, using biopsies from patients with uveal melanoma and single ce...
www.nature.com
April 4, 2025 at 7:00 AM
🚀New research published in @naturecomms.bsky.social!
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG
📎 www.nature.com/articles/s41...
👉'Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer', with @paulanietog.bsky.social and @hoheyn.bsky.social from CNAG
📎 www.nature.com/articles/s41...
Reposted by Holger Heyn
🌟Big step in #PrecisionMedicine: CNAG publishes an inflammation atlas with 6.5 million single cells from 1,047 patients across 19 diseases!
🎯Key to understanding inflammation in infections, autoimmune diseases & cancer
Led by @hoheyn.bsky.social, under Doctis Proj.
www.biorxiv.org/content/10.1...
🎯Key to understanding inflammation in infections, autoimmune diseases & cancer
Led by @hoheyn.bsky.social, under Doctis Proj.
www.biorxiv.org/content/10.1...
www.biorxiv.org
April 11, 2025 at 9:44 AM
🌟Big step in #PrecisionMedicine: CNAG publishes an inflammation atlas with 6.5 million single cells from 1,047 patients across 19 diseases!
🎯Key to understanding inflammation in infections, autoimmune diseases & cancer
Led by @hoheyn.bsky.social, under Doctis Proj.
www.biorxiv.org/content/10.1...
🎯Key to understanding inflammation in infections, autoimmune diseases & cancer
Led by @hoheyn.bsky.social, under Doctis Proj.
www.biorxiv.org/content/10.1...
Reposted by Holger Heyn
🌎 This week, we crossed the ocean to Canada to take part in the @keystonesymposia.bsky.social #SingleCell Biology: Unique Cells to #Tissue Ecosystems
🗣️ Our Single Cell Genomics Group Leader at CNAG, @hoheyn.bsky.social, presented “The Power of a Million Cells”
#KSSingleCell25 #KeystoneConferences
🗣️ Our Single Cell Genomics Group Leader at CNAG, @hoheyn.bsky.social, presented “The Power of a Million Cells”
#KSSingleCell25 #KeystoneConferences
May 16, 2025 at 8:13 AM
🌎 This week, we crossed the ocean to Canada to take part in the @keystonesymposia.bsky.social #SingleCell Biology: Unique Cells to #Tissue Ecosystems
🗣️ Our Single Cell Genomics Group Leader at CNAG, @hoheyn.bsky.social, presented “The Power of a Million Cells”
#KSSingleCell25 #KeystoneConferences
🗣️ Our Single Cell Genomics Group Leader at CNAG, @hoheyn.bsky.social, presented “The Power of a Million Cells”
#KSSingleCell25 #KeystoneConferences
Ever wondered why we do all these #Omics?
Here is your answer: biorxiv.org/content/10.1... 📜
Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.
Here is your answer: biorxiv.org/content/10.1... 📜
Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.
Systematic evaluation of single-cell multimodal data integration for comprehensive human reference atlas.
The integration of multimodal single-cell data enables comprehensive organ reference atlases, yet its impact remains largely unexplored, particularly in complex tissues. We generated a benchmarking da...
biorxiv.org
March 7, 2025 at 7:01 PM
Ever wondered why we do all these #Omics?
Here is your answer: biorxiv.org/content/10.1... 📜
Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.
Here is your answer: biorxiv.org/content/10.1... 📜
Multi-Omics integration of a Human Cell Atlas
@humancellatlas.org of the Kidney, coordinated by the #HCA Standards and Technology Working Group and co-led by
@elimereu.bsky.social.
TICK tock. Your Immune clock is ticking! -Immune Age-
@omniscope.bsky.social is launching a suite of Immune Tracking products at #MWC2025
Immune Age uses T cells as living sensors, a new Biomarker strategy to quantify #BiologicalAge (@erictopol.bsky.social : erictopol.substack.com/p/steve-horv...)
@omniscope.bsky.social is launching a suite of Immune Tracking products at #MWC2025
Immune Age uses T cells as living sensors, a new Biomarker strategy to quantify #BiologicalAge (@erictopol.bsky.social : erictopol.substack.com/p/steve-horv...)
March 5, 2025 at 8:03 AM
TICK tock. Your Immune clock is ticking! -Immune Age-
@omniscope.bsky.social is launching a suite of Immune Tracking products at #MWC2025
Immune Age uses T cells as living sensors, a new Biomarker strategy to quantify #BiologicalAge (@erictopol.bsky.social : erictopol.substack.com/p/steve-horv...)
@omniscope.bsky.social is launching a suite of Immune Tracking products at #MWC2025
Immune Age uses T cells as living sensors, a new Biomarker strategy to quantify #BiologicalAge (@erictopol.bsky.social : erictopol.substack.com/p/steve-horv...)
YOU NEVER WALK ALONE 💛 🖤 🤍
Building a company is no easy task—but doing it with friends is a recipe for success.
Thanks so much to my co-founders Vijay and Lynnette
@omniscope.bsky.social and @fcbarcelonamain.bsky.social
for your support! 🔥
Building a company is no easy task—but doing it with friends is a recipe for success.
Thanks so much to my co-founders Vijay and Lynnette
@omniscope.bsky.social and @fcbarcelonamain.bsky.social
for your support! 🔥
March 3, 2025 at 9:26 AM
YOU NEVER WALK ALONE 💛 🖤 🤍
Building a company is no easy task—but doing it with friends is a recipe for success.
Thanks so much to my co-founders Vijay and Lynnette
@omniscope.bsky.social and @fcbarcelonamain.bsky.social
for your support! 🔥
Building a company is no easy task—but doing it with friends is a recipe for success.
Thanks so much to my co-founders Vijay and Lynnette
@omniscope.bsky.social and @fcbarcelonamain.bsky.social
for your support! 🔥
Reposted by Holger Heyn
Excited to collaborate with @hoheyn.bsky.social, @jcnietos.bsky.social, @paulanietog.bsky.social & team on leptomeningeal metastatic disease - a key challenge in #NeuroOncology. Our study reveals unique immune responses in CSF, highlighting CSF liquid biopsy’s potential to guide CNS tumor therapies.
📢 SUPER EXCITED to share our latest preprint:
Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid
Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others.
biorxiv.org/content/10.110…
Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid
Incredible work and collaboration from @jcnietos.bsky.social @piazeiner.bsky.social @hoheyn.bsky.social and others.
biorxiv.org/content/10.110…
https://biorxiv.org/content/10.110…
January 29, 2025 at 12:33 PM
Excited to collaborate with @hoheyn.bsky.social, @jcnietos.bsky.social, @paulanietog.bsky.social & team on leptomeningeal metastatic disease - a key challenge in #NeuroOncology. Our study reveals unique immune responses in CSF, highlighting CSF liquid biopsy’s potential to guide CNS tumor therapies.
XMAS Exercise: #review writing
T Cell Sequencing for Next-Gen Clinical Diagnostics
Every day until Christmas, I’ll be dropping #TCR-seq insights to better Detect and Treat!
Get your socks ready for a daily boost of Science to balance out the holiday sugar rush.
#ScienceIsWeAll
T Cell Sequencing for Next-Gen Clinical Diagnostics
Every day until Christmas, I’ll be dropping #TCR-seq insights to better Detect and Treat!
Get your socks ready for a daily boost of Science to balance out the holiday sugar rush.
#ScienceIsWeAll
November 29, 2024 at 4:41 PM
XMAS Exercise: #review writing
T Cell Sequencing for Next-Gen Clinical Diagnostics
Every day until Christmas, I’ll be dropping #TCR-seq insights to better Detect and Treat!
Get your socks ready for a daily boost of Science to balance out the holiday sugar rush.
#ScienceIsWeAll
T Cell Sequencing for Next-Gen Clinical Diagnostics
Every day until Christmas, I’ll be dropping #TCR-seq insights to better Detect and Treat!
Get your socks ready for a daily boost of Science to balance out the holiday sugar rush.
#ScienceIsWeAll
The REAL Superpower of Deep T Cell Sequencing!
We tracked #singlecell from Tumor to Blood.
We identified ICI-induced T cells.
We quantified T cell memory.
We designed personalized TCR-T therapy.
Amazing collab w/ Omniscope, CNAG and @irbbarcelona.bsky.social.
www.biorxiv.org/content/10.1...
We tracked #singlecell from Tumor to Blood.
We identified ICI-induced T cells.
We quantified T cell memory.
We designed personalized TCR-T therapy.
Amazing collab w/ Omniscope, CNAG and @irbbarcelona.bsky.social.
www.biorxiv.org/content/10.1...
Spatio-temporal T cell tracking for personalized TCR-T designs in childhood cancer
Immune checkpoint inhibition (ICI) has revolutionized oncology, offering extended survival and long-term remission in previously incurable cancers. While highly effective in tumors with high mutationa...
www.biorxiv.org
November 29, 2024 at 4:25 PM
The REAL Superpower of Deep T Cell Sequencing!
We tracked #singlecell from Tumor to Blood.
We identified ICI-induced T cells.
We quantified T cell memory.
We designed personalized TCR-T therapy.
Amazing collab w/ Omniscope, CNAG and @irbbarcelona.bsky.social.
www.biorxiv.org/content/10.1...
We tracked #singlecell from Tumor to Blood.
We identified ICI-induced T cells.
We quantified T cell memory.
We designed personalized TCR-T therapy.
Amazing collab w/ Omniscope, CNAG and @irbbarcelona.bsky.social.
www.biorxiv.org/content/10.1...
OUT NOW!
Adaptive Evolution of the Human Immune Cell Landscape.
"Human adaptation controls pathogen spread at early stages of infection with specific states at strategic barrier sites".
Our (late) contribution to the HCA-Nature bundle.
www.nature.com/articles/s41...
Adaptive Evolution of the Human Immune Cell Landscape.
"Human adaptation controls pathogen spread at early stages of infection with specific states at strategic barrier sites".
Our (late) contribution to the HCA-Nature bundle.
www.nature.com/articles/s41...
Adaptation in human immune cells residing in tissues at the frontline of infections - Nature Communications
Immune cells are under evolutionary pressure due to their anti-infective defence role. Here Salvador-Martínez and Murga-Moreno et al. combine population genetics approaches and Human Cell Atlas data, ...
www.nature.com
November 29, 2024 at 4:23 PM
OUT NOW!
Adaptive Evolution of the Human Immune Cell Landscape.
"Human adaptation controls pathogen spread at early stages of infection with specific states at strategic barrier sites".
Our (late) contribution to the HCA-Nature bundle.
www.nature.com/articles/s41...
Adaptive Evolution of the Human Immune Cell Landscape.
"Human adaptation controls pathogen spread at early stages of infection with specific states at strategic barrier sites".
Our (late) contribution to the HCA-Nature bundle.
www.nature.com/articles/s41...