Hocek lab
@hoceklab.bsky.social
Research group at IOCB Prague and Charles University working in bioorganic and medicinal chemistry of nucleic acids and their components. http://hocekgroup.uochb.cas.cz/
Our new paper on Enzymatic synthesis of base-modified RNA and influence of the modifications on stability, translation, and CRISPR-Cas9 cleavage - published in ACS Chem. Biol.: doi.org/10.1021/acsc.... @iocbprague.bsky.social @sciencecharles.bsky.social @akademievedcr.bsky.social
November 12, 2025 at 10:10 AM
Our new paper on Enzymatic synthesis of base-modified RNA and influence of the modifications on stability, translation, and CRISPR-Cas9 cleavage - published in ACS Chem. Biol.: doi.org/10.1021/acsc.... @iocbprague.bsky.social @sciencecharles.bsky.social @akademievedcr.bsky.social
Our newest paper Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase-Modified Aptamers Demonstrated on Indole-Modified β-Conglutin Aptamer published in ChemBioChem: doi.org/10.1002/cbic... ; @iocbprague.bsky.social
September 30, 2025 at 1:11 PM
Our newest paper Versatile Enzymatic Approach for Truncation, Labeling, and Mutation of Nucleobase-Modified Aptamers Demonstrated on Indole-Modified β-Conglutin Aptamer published in ChemBioChem: doi.org/10.1002/cbic... ; @iocbprague.bsky.social
New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social
September 9, 2025 at 2:50 PM
New paper in great collaboration with @cardosolab.bsky.social on Super-Resolution Compatible DNA Labeling Technique Reveals Chromatin Mobility and Organization Changes During Differentiation published in Advanced Science: doi.org/10.1002/advs... @iocbprague.bsky.social
Polymerase synthesis of base-modified DNA scaled-up to milligram quantities suitable for NMR structure studies. Check our newest work published in ChemistryEurope doi.org/10.1002/ceur... @iocbprague.bsky.social
August 7, 2025 at 12:56 PM
Polymerase synthesis of base-modified DNA scaled-up to milligram quantities suitable for NMR structure studies. Check our newest work published in ChemistryEurope doi.org/10.1002/ceur... @iocbprague.bsky.social
Natalia Kuprikova has successfully defended (at the Charles University) her PhD thesis entitled Enzymatic synthesis of hypermodified DNA bearing anionic or cationic functional groups. PhD No. 48 from the Hocek group. Congratulations!
June 2, 2025 at 1:41 PM
Natalia Kuprikova has successfully defended (at the Charles University) her PhD thesis entitled Enzymatic synthesis of hypermodified DNA bearing anionic or cationic functional groups. PhD No. 48 from the Hocek group. Congratulations!
Our newest paper on enzymatic incorporation of 2-substituted adenine nucleotides into RNA and their use for RNA labeling has been published in ChemBioChem: doi.org/10.1002/cbic... @iocbprague.bsky.social
May 22, 2025 at 11:00 AM
Our newest paper on enzymatic incorporation of 2-substituted adenine nucleotides into RNA and their use for RNA labeling has been published in ChemBioChem: doi.org/10.1002/cbic... @iocbprague.bsky.social
Ugnė Šinkevičiūtė has successfully defended the Charles University her PhD thesis entitled: New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors. PhD No. 47 from the Hocek group. Congratulations !
March 21, 2025 at 3:21 PM
Ugnė Šinkevičiūtė has successfully defended the Charles University her PhD thesis entitled: New deazapurine nucleobases, nucleosides and nucleotides as potential cytostatics or CD73 inhibitors. PhD No. 47 from the Hocek group. Congratulations !
Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...
March 10, 2025 at 10:09 AM
Our newest paper on enzymatic synthesis of hypermodified zwitterionic DNA bearing 4 different cationic groups has just been published in NAR. doi.org/10.1093/nar/...
Filip Gracias has successfully defended at UCT Prague his PhD thesis entitled: Synthesis of epigenetic pyrimidine nucleotides and their non-natural analogues for regulation of transcription. PhD No. 46 from the Hocek group. Congratulations Dr. Gracias! @iocbprague.bsky.social
February 28, 2025 at 11:10 AM
Filip Gracias has successfully defended at UCT Prague his PhD thesis entitled: Synthesis of epigenetic pyrimidine nucleotides and their non-natural analogues for regulation of transcription. PhD No. 46 from the Hocek group. Congratulations Dr. Gracias! @iocbprague.bsky.social
Our new paper (collaboration with P. Rezacova group) on the use of environment-sensitive fluorophore-linked nucleotide in DNA probes for identification of effectors of TFs and studying conformational changes of protein-DNA complexes has been published in RSC Chem. Biol.: doi.org/10.1039/D4CB...
January 15, 2025 at 4:07 PM
Our new paper (collaboration with P. Rezacova group) on the use of environment-sensitive fluorophore-linked nucleotide in DNA probes for identification of effectors of TFs and studying conformational changes of protein-DNA complexes has been published in RSC Chem. Biol.: doi.org/10.1039/D4CB...