Quan Le
@hmquanle.bsky.social
Making molecular tools from proteins 🧬🛠 with @johntngo and co
@BU-BME || PhD Candidate 👨🔬 || #ProteinEngineering #synbio #biotech #science
@BU-BME || PhD Candidate 👨🔬 || #ProteinEngineering #synbio #biotech #science
Reposted by Quan Le
My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.
August 20, 2025 at 9:14 PM
My lab at BU is looking to hire a post-doc with experience in biophysics, protein engineering, and chemical (or synthetic) biology. The anticipated start date is Jan 2026. Please send a resume, cover letter, and names/emails for 3 references. We are looking to interview people during Sept/Oct 2025.
I'm excited to share our latest work on developing a method to engineer drug-activatable nanobodies using a viral protease against a variety of targets. Thank you to my PI Dr. John Ngo, labmates @alex-marzilli.bsky.social, @jeremyctran.bsky.social and Chris Kuffner for their help during the project.
Quan Le engineered intracellular nanobodies that can be stabilized and activated by NS3 protease inhibitors. By inserting NS3 at key sites, he created drug-sensitive nanobodies targeting GFP, mCherry, ALFA tag, and the β2-adrenergic receptor. Check it out here:
Protease-Containing Nanobodies for Detecting and Manipulating Intracellular Antigens Using Antiviral Drugs
Tools to induce the formation of protein–protein interactions (PPIs) via small molecules are essential for investigating and engineering biological systems. Here we introduce a protease-based strategy...
pubs.acs.org
May 12, 2025 at 6:06 PM
I'm excited to share our latest work on developing a method to engineer drug-activatable nanobodies using a viral protease against a variety of targets. Thank you to my PI Dr. John Ngo, labmates @alex-marzilli.bsky.social, @jeremyctran.bsky.social and Chris Kuffner for their help during the project.