Henry L Niman PhD
@hlniman.bsky.social
Some of the Canadian A(H5N5) viruses
birds and mammals possessed the PB2-E627K
Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission.
www.cell.com/cell-reports...
birds and mammals possessed the PB2-E627K
Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission.
www.cell.com/cell-reports...
Multiple transatlantic incursions of highly pathogenic avian influenza clade 2.3.4.4b A(H5N5) virus into North America and spillover to mammals
Erdelyan et al. reveal that seabirds likely facilitated the spread of A(H5N5) viruses
from Europe to Canada. All viral segments were Eurasian. Hemagglutinin contained substitutions
not present in Cana...
www.cell.com
November 14, 2025 at 11:52 PM
Some of the Canadian A(H5N5) viruses
birds and mammals possessed the PB2-E627K
Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission.
www.cell.com/cell-reports...
birds and mammals possessed the PB2-E627K
Ferrets inoculated with A(H5N5) viruses showed rapid, severe disease onset, with some evidence of direct contact transmission.
www.cell.com/cell-reports...
H5N5 with PB2 E627K
A6 genotype
A/Red_Fox/NS/FAV-0171-1/2025 | 3/26/25
A/Striped_Skunk/PEI/FAV-0130-1/2024 4/9/24
A/Raccoon/NS/FAV-0079-1/2024 | 2/2/24
A/black vulture/USA/021407-019/2025
A/common raven/USA/019390-017/2025
A/common raven/USA/019390-016/2025
A6 genotype
A/Red_Fox/NS/FAV-0171-1/2025 | 3/26/25
A/Striped_Skunk/PEI/FAV-0130-1/2024 4/9/24
A/Raccoon/NS/FAV-0079-1/2024 | 2/2/24
A/black vulture/USA/021407-019/2025
A/common raven/USA/019390-017/2025
A/common raven/USA/019390-016/2025
November 14, 2025 at 11:11 PM
H5N5 with PB2 E627K
A6 genotype
A/Red_Fox/NS/FAV-0171-1/2025 | 3/26/25
A/Striped_Skunk/PEI/FAV-0130-1/2024 4/9/24
A/Raccoon/NS/FAV-0079-1/2024 | 2/2/24
A/black vulture/USA/021407-019/2025
A/common raven/USA/019390-017/2025
A/common raven/USA/019390-016/2025
A6 genotype
A/Red_Fox/NS/FAV-0171-1/2025 | 3/26/25
A/Striped_Skunk/PEI/FAV-0130-1/2024 4/9/24
A/Raccoon/NS/FAV-0079-1/2024 | 2/2/24
A/black vulture/USA/021407-019/2025
A/common raven/USA/019390-017/2025
A/common raven/USA/019390-016/2025
H5N5
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
H5N5 Avian influenza confirmed in Grays Harbor County resident First detection of this strain in a human, risk to the public remains low
For immediate release: November 14, 2024 (25-138) Contact: DOH Communications
doh.wa.gov
November 14, 2025 at 10:29 PM
H5N5
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
H5N5
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
H5N5 Avian influenza confirmed in Grays Harbor County resident First detection of this strain in a human, risk to the public remains low
For immediate release: November 14, 2024 (25-138) Contact: DOH Communications
doh.wa.gov
November 14, 2025 at 10:29 PM
H5N5
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
mixed backyard flock of domestic poultry at home that had exposure to wild birds
Above is cause for concern
Previously (2024/2025)
in eastern Canada mammals
incl some with PB2 E627K
Genotype A6
Human case appears to be seriously ill
doh.wa.gov/newsroom/h5n...
Additional testing shows the virus to be H5N5, an avian influenza virus that has previously been reported in animals but never before in humans
not #H5N1
www.kxro.com/confirmed-ca...
not #H5N1
www.kxro.com/confirmed-ca...
Confirmed Case of Avian Influenza (“Bird Flu”) in Grays Harbor County - KXRO News Radio
KXRO has learned that the Washington State Department of health has confirmed that a case of avian...
www.kxro.com
November 14, 2025 at 9:26 PM
Additional testing shows the virus to be H5N5, an avian influenza virus that has previously been reported in animals but never before in humans
not #H5N1
www.kxro.com/confirmed-ca...
not #H5N1
www.kxro.com/confirmed-ca...
treatment in King County
after treated in Thurston and Grays Harbor counties
3 WA cos
presumptive #H5N1 will be conf
"respiratory distress" likely increasing
to facility more equiped for containment and treatment
doh.wa.gov/newsroom/gra...
after treated in Thurston and Grays Harbor counties
3 WA cos
presumptive #H5N1 will be conf
"respiratory distress" likely increasing
to facility more equiped for containment and treatment
doh.wa.gov/newsroom/gra...
Grays Harbor County resident tests preliminarily positive for avian influenza
For immediate release: November 13, 2025 (25-136) Contact: DOH Communications
doh.wa.gov
November 14, 2025 at 5:13 PM
treatment in King County
after treated in Thurston and Grays Harbor counties
3 WA cos
presumptive #H5N1 will be conf
"respiratory distress" likely increasing
to facility more equiped for containment and treatment
doh.wa.gov/newsroom/gra...
after treated in Thurston and Grays Harbor counties
3 WA cos
presumptive #H5N1 will be conf
"respiratory distress" likely increasing
to facility more equiped for containment and treatment
doh.wa.gov/newsroom/gra...
respiratory distress
King Co WA
Thurston & Grays Harbor Cos treat / hosp
presump #H5N1 pos
3rd North American w/ resp distress
(orig H5N1 case def)
A/British_Columbia/PHL-2032/2024 | 11/9/24
ECMO
hosp 2 mo
A/Louisiana/12/2024 | 12/11/24
fatal
Both D1.1 RBD E190D
doh.wa.gov/newsroom/gra...
King Co WA
Thurston & Grays Harbor Cos treat / hosp
presump #H5N1 pos
3rd North American w/ resp distress
(orig H5N1 case def)
A/British_Columbia/PHL-2032/2024 | 11/9/24
ECMO
hosp 2 mo
A/Louisiana/12/2024 | 12/11/24
fatal
Both D1.1 RBD E190D
doh.wa.gov/newsroom/gra...
Grays Harbor County resident tests preliminarily positive for avian influenza
For immediate release: November 13, 2025 (25-136) Contact: DOH Communications
doh.wa.gov
November 14, 2025 at 11:35 AM
respiratory distress
King Co WA
Thurston & Grays Harbor Cos treat / hosp
presump #H5N1 pos
3rd North American w/ resp distress
(orig H5N1 case def)
A/British_Columbia/PHL-2032/2024 | 11/9/24
ECMO
hosp 2 mo
A/Louisiana/12/2024 | 12/11/24
fatal
Both D1.1 RBD E190D
doh.wa.gov/newsroom/gra...
King Co WA
Thurston & Grays Harbor Cos treat / hosp
presump #H5N1 pos
3rd North American w/ resp distress
(orig H5N1 case def)
A/British_Columbia/PHL-2032/2024 | 11/9/24
ECMO
hosp 2 mo
A/Louisiana/12/2024 | 12/11/24
fatal
Both D1.1 RBD E190D
doh.wa.gov/newsroom/gra...
Early Nov hosp
high fever
confusion
respiratory distress
King County WA
after Thurston & Grays Harbor Cos treatment / hosp
presumptive #H5N1 pos
minimal info at WA DoH
Pacific flyway
no source cited
no CDC update
similarities w/ fatal 2024 D1.1 Louisiana case
doh.wa.gov/newsroom/gra...
high fever
confusion
respiratory distress
King County WA
after Thurston & Grays Harbor Cos treatment / hosp
presumptive #H5N1 pos
minimal info at WA DoH
Pacific flyway
no source cited
no CDC update
similarities w/ fatal 2024 D1.1 Louisiana case
doh.wa.gov/newsroom/gra...
Grays Harbor County resident tests preliminarily positive for avian influenza
For immediate release: November 13, 2025 (25-136) Contact: DOH Communications
doh.wa.gov
November 14, 2025 at 9:43 AM
Early Nov hosp
high fever
confusion
respiratory distress
King County WA
after Thurston & Grays Harbor Cos treatment / hosp
presumptive #H5N1 pos
minimal info at WA DoH
Pacific flyway
no source cited
no CDC update
similarities w/ fatal 2024 D1.1 Louisiana case
doh.wa.gov/newsroom/gra...
high fever
confusion
respiratory distress
King County WA
after Thurston & Grays Harbor Cos treatment / hosp
presumptive #H5N1 pos
minimal info at WA DoH
Pacific flyway
no source cited
no CDC update
similarities w/ fatal 2024 D1.1 Louisiana case
doh.wa.gov/newsroom/gra...
older adult
underlying health conditions
high fever, confusion, and respiratory distress
hospitalized in early November
King County WA
prior Thurston and Grays Harbor
H5 presumptive pos
Likely #H5N1
D1.1 genotype base on location
doh.wa.gov/newsroom/gra...
underlying health conditions
high fever, confusion, and respiratory distress
hospitalized in early November
King County WA
prior Thurston and Grays Harbor
H5 presumptive pos
Likely #H5N1
D1.1 genotype base on location
doh.wa.gov/newsroom/gra...
Grays Harbor County resident tests preliminarily positive for avian influenza
For immediate release: November 13, 2025 (25-136) Contact: DOH Communications
doh.wa.gov
November 14, 2025 at 8:20 AM
older adult
underlying health conditions
high fever, confusion, and respiratory distress
hospitalized in early November
King County WA
prior Thurston and Grays Harbor
H5 presumptive pos
Likely #H5N1
D1.1 genotype base on location
doh.wa.gov/newsroom/gra...
underlying health conditions
high fever, confusion, and respiratory distress
hospitalized in early November
King County WA
prior Thurston and Grays Harbor
H5 presumptive pos
Likely #H5N1
D1.1 genotype base on location
doh.wa.gov/newsroom/gra...
November 13, 2025 at 11:25 PM
November 13, 2025 at 12:33 AM
November 12, 2025 at 9:50 PM
November 11, 2025 at 2:02 AM
November 10, 2025 at 2:12 PM
November 9, 2025 at 11:56 PM
November 8, 2025 at 9:39 PM
November 8, 2025 at 4:52 PM
November 8, 2025 at 9:08 AM
November 6, 2025 at 4:47 PM
November 5, 2025 at 7:59 PM
November 5, 2025 at 6:21 PM
November 5, 2025 at 6:18 PM
November 5, 2025 at 4:27 AM
November 4, 2025 at 2:49 AM
November 2, 2025 at 4:40 AM