Hi! It’s great if I could be added there

Thank you! Hope you like it.
This is the direct link to the preprint (somehow the doi link is broken)

doi.org/10.1101/2024...

🔗: www.medrxiv.org/content/10.1...

Link to the tweetrial on X
twitter.com/mepbphhond_/...

Archive:
hiroaki-murayama.github.io/posts/2024/1...

Finally, a big thank you to all co-authors!
@Toshiaki_R_A, Borame L Dickens, Jen Han Foo, Shihui Jin, Patrick K Mukadi, @EjimaKeisuke, @Sungmok_J, @Nishi_Akihiro, @kiesha_prem & @_akiraendo
9/9

In the 2022 clade IIb outbreak, mpox showed a rapid spread among men who have sex with men. This time, clade Ib may have found its niche among FSWs, another key population group. Our findings reemphasise the importance of prioritising support for those key groups for control.
8/9

Our estimates suggest sexual contact contributes 41% to the effective reproduction number (Reff) in the Kivus, consistent with clade Ib’s Reff of ~ 1.5 in the Kivus vs ~0.9 for clade Ia in endemic provinces, underscoring the need for targeted control in high-risk contact settings.
7/9

Using the same age-dependent susceptibility estimates, we developed an extended model with additional sexual contact routes and fitted it to the age-sex distribution of cases in clade Ib-affected regions to explain the apparent excess among sexually-active age groups.
6/9

Estimating susceptibility in children and smallpox-immunised cohorts with historical clade Ia cases in DRC (2011-2015), we found the contact matrix well explained the age distribution of clade Ia cases in 2024, suggesting community contacts as the main driver of transmission.
5/9

To assess the relative contribution of community and sexual contact transmission, we modelled age- and sex-dependent contact patterns to explain the observed age/sex profiles of clade Ia and Ib cases.
4/9

Although initial investigation of the clade Ib outbreak found heterosexual contacts among female sex workers (FSWs) and their clients as key exposure routes, general community contacts may play a role, with children accounting for a significant proportion of reported cases.
3/9

Clade Ia MPXV has historically circulated in DRC mainly through animal exposure followed by limited human-to-human transmission. In contrast, the rapid spread of clade Ib in South Kivu, DRC suggested sustained human-to-human transmission.
2/9