Hernán A. Burbano
@hernanaburbano.bsky.social
Professor of Ancient Genomics and Evolution, GEE, University College London.
www.burbanolab.org
www.burbanolab.org
Why does the trade-off persist?
Because both competition and colonization hinge on the same surface molecule. The O-antigen is a case of antagonistic pleiotropy – you can’t optimize one function without hurting the other.
(6/n)
Because both competition and colonization hinge on the same surface molecule. The O-antigen is a case of antagonistic pleiotropy – you can’t optimize one function without hurting the other.
(6/n)
November 18, 2025 at 8:41 AM
Why does the trade-off persist?
Because both competition and colonization hinge on the same surface molecule. The O-antigen is a case of antagonistic pleiotropy – you can’t optimize one function without hurting the other.
(6/n)
Because both competition and colonization hinge on the same surface molecule. The O-antigen is a case of antagonistic pleiotropy – you can’t optimize one function without hurting the other.
(6/n)
What surprised us: this trade-off isn’t transient.
Using herbarium samples up to 200 years old, we show that the same genetic variants have persisted across 10⁵–10⁶ generations, with no evidence of widespread escape via recombination.
Natural selection keeps circling the same solutions.
(5/n)
Using herbarium samples up to 200 years old, we show that the same genetic variants have persisted across 10⁵–10⁶ generations, with no evidence of widespread escape via recombination.
Natural selection keeps circling the same solutions.
(5/n)
November 18, 2025 at 8:41 AM
What surprised us: this trade-off isn’t transient.
Using herbarium samples up to 200 years old, we show that the same genetic variants have persisted across 10⁵–10⁶ generations, with no evidence of widespread escape via recombination.
Natural selection keeps circling the same solutions.
(5/n)
Using herbarium samples up to 200 years old, we show that the same genetic variants have persisted across 10⁵–10⁶ generations, with no evidence of widespread escape via recombination.
Natural selection keeps circling the same solutions.
(5/n)
Many Gram negative bacteria fight using tailocins – phage-derived molecular weapons that kill close relatives by binding to specific O-antigen receptors on the cell surface.
Powerful in warfare… but costly.
(3/n)
Powerful in warfare… but costly.
(3/n)
November 18, 2025 at 8:41 AM
Many Gram negative bacteria fight using tailocins – phage-derived molecular weapons that kill close relatives by binding to specific O-antigen receptors on the cell surface.
Powerful in warfare… but costly.
(3/n)
Powerful in warfare… but costly.
(3/n)
Our new collaborative work led by @taliamycota.bsky.social
Jiajun Cui & Emma Caullireau between my lab @ucllifesciences.bsky.social @cloeucl.bsky.social & the Karasov Lab (tkarasovlab.org) @uofubiology.bsky.social
and collaborators: @plantricia.bsky.social et al.
tinyurl.com/5yx2wmz5
(1/n)
Jiajun Cui & Emma Caullireau between my lab @ucllifesciences.bsky.social @cloeucl.bsky.social & the Karasov Lab (tkarasovlab.org) @uofubiology.bsky.social
and collaborators: @plantricia.bsky.social et al.
tinyurl.com/5yx2wmz5
(1/n)
November 18, 2025 at 8:41 AM
Our new collaborative work led by @taliamycota.bsky.social
Jiajun Cui & Emma Caullireau between my lab @ucllifesciences.bsky.social @cloeucl.bsky.social & the Karasov Lab (tkarasovlab.org) @uofubiology.bsky.social
and collaborators: @plantricia.bsky.social et al.
tinyurl.com/5yx2wmz5
(1/n)
Jiajun Cui & Emma Caullireau between my lab @ucllifesciences.bsky.social @cloeucl.bsky.social & the Karasov Lab (tkarasovlab.org) @uofubiology.bsky.social
and collaborators: @plantricia.bsky.social et al.
tinyurl.com/5yx2wmz5
(1/n)
Published version of our collaborative work! Congrats to @laskyjr.bsky.social @upenn.edu & Lua Lopez who lead the work, and to all the authors. tinyurl.com/mu8uht92 @ucllifesciences.bsky.social @cloeucl.bsky.social
August 14, 2025 at 10:00 AM
Published version of our collaborative work! Congrats to @laskyjr.bsky.social @upenn.edu & Lua Lopez who lead the work, and to all the authors. tinyurl.com/mu8uht92 @ucllifesciences.bsky.social @cloeucl.bsky.social
A primer by Sergio Latorre @smlatorreo.bsky.social tinyurl.com/ye8zwcrc on the paper by Jigisha et al. "Popgen and molecular epidemiology of wheat powdery mildew" @plosbiology.org tinyurl.com/357nkey8 @ucllifesciences.bsky.social @cloeucl.bsky.social
May 6, 2025 at 8:25 AM
A primer by Sergio Latorre @smlatorreo.bsky.social tinyurl.com/ye8zwcrc on the paper by Jigisha et al. "Popgen and molecular epidemiology of wheat powdery mildew" @plosbiology.org tinyurl.com/357nkey8 @ucllifesciences.bsky.social @cloeucl.bsky.social
Our new collaborative paper led by @laskyjr.bsky.social 's @upenn.edu & Lua Lopez's Cal State U Labs. tinyurl.com/2hsdzd68 @ucllifesciences.bsky.social #herbarium #genomics Stasis and Genetic diversity in Arabidopsis thaliana across centuries.
February 17, 2025 at 7:08 PM
Our new collaborative paper led by @laskyjr.bsky.social 's @upenn.edu & Lua Lopez's Cal State U Labs. tinyurl.com/2hsdzd68 @ucllifesciences.bsky.social #herbarium #genomics Stasis and Genetic diversity in Arabidopsis thaliana across centuries.
Check also our recent original paper on Tailocins: tinyurl.com/y85b2xn9
November 26, 2024 at 7:49 AM
Check also our recent original paper on Tailocins: tinyurl.com/y85b2xn9