Henry McSorley
@henrymcsorley.bsky.social
I use parasites to mess with the immune system. Reader at University of Dundee. I also like bikes and cats.
Great pic! It’s a lovely area
October 26, 2025 at 6:05 PM
Great pic! It’s a lovely area
congrats - beautiful work!
October 23, 2025 at 8:07 PM
congrats - beautiful work!
Done! 7 laps, 67 km. To be clear, the race is still going on, IM done. 3000 calories - could eat… strava.app.link/8fs8DA6u0Wb
September 27, 2025 at 3:31 PM
Done! 7 laps, 67 km. To be clear, the race is still going on, IM done. 3000 calories - could eat… strava.app.link/8fs8DA6u0Wb
A Marshall just shouted “only 3 hours left!” And the look I gave him did this.
a man wearing glasses and a hat is laughing with his tongue out
ALT: a man wearing glasses and a hat is laughing with his tongue out
media.tenor.com
September 27, 2025 at 2:16 PM
A Marshall just shouted “only 3 hours left!” And the look I gave him did this.
Lap 5 update
a man with a mustache is laying on a couch and says screaming
ALT: a man with a mustache is laying on a couch and says screaming
media.tenor.com
September 27, 2025 at 1:16 PM
Lap 5 update
Lap 4 update: oh no
September 27, 2025 at 12:05 PM
Lap 4 update: oh no
Currently done lap 3 and has gone exactly as above, with a major crash due to overexcitement. (Bike and rider are fine)
I plan to learn nothing from this.
I plan to learn nothing from this.
September 27, 2025 at 11:13 AM
Currently done lap 3 and has gone exactly as above, with a major crash due to overexcitement. (Bike and rider are fine)
I plan to learn nothing from this.
I plan to learn nothing from this.
My usual performance goes:
Lap 1: take it slow, pace yourself.
Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next…
Lap 3: imma do a hot lap!
Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no.
Lap 5: screaming, crying, throwing up
Lap 1: take it slow, pace yourself.
Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next…
Lap 3: imma do a hot lap!
Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no.
Lap 5: screaming, crying, throwing up
September 27, 2025 at 11:13 AM
My usual performance goes:
Lap 1: take it slow, pace yourself.
Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next…
Lap 3: imma do a hot lap!
Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no.
Lap 5: screaming, crying, throwing up
Lap 1: take it slow, pace yourself.
Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next…
Lap 3: imma do a hot lap!
Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no.
Lap 5: screaming, crying, throwing up
Thats where the story ends at the moment - we would love to look at the in vivo effects of HpBoRB against RELM-beta (does it suppress RELM-beta's activity?) but we ran out of time in Viv's PhD. If anyone has any interesting RELM-beta assays they would like to try HpBoRB in, hit us up!
September 25, 2025 at 7:28 AM
Thats where the story ends at the moment - we would love to look at the in vivo effects of HpBoRB against RELM-beta (does it suppress RELM-beta's activity?) but we ran out of time in Viv's PhD. If anyone has any interesting RELM-beta assays they would like to try HpBoRB in, hit us up!
We then confirmed this binding in a number of ELISA, SPR and gel filtration assays - it is a high-affinity (subnanomolar) interaction.
September 25, 2025 at 7:28 AM
We then confirmed this binding in a number of ELISA, SPR and gel filtration assays - it is a high-affinity (subnanomolar) interaction.
We screened the CCP domain protein family to see if there were other host immune factor binders, using an AVEXIS protein-protein interaction screen. The screen confirmed that HpBARI binds ST2, and that TGM1 binds TGFBR2 (reassuring) and identified one new hit - a protein which bound RELM-beta.
September 25, 2025 at 7:28 AM
We screened the CCP domain protein family to see if there were other host immune factor binders, using an AVEXIS protein-protein interaction screen. The screen confirmed that HpBARI binds ST2, and that TGM1 binds TGFBR2 (reassuring) and identified one new hit - a protein which bound RELM-beta.
This story started when we realised that all of the immunomodulators we had identified from Hpb (HpARI, HpBARI and TGM) were related in their domain structure - all consist of strings of CCP domains. Turns out the CCP domain family is massively (and uniquely) expanded in the Hpb genome.
September 25, 2025 at 7:28 AM
This story started when we realised that all of the immunomodulators we had identified from Hpb (HpARI, HpBARI and TGM) were related in their domain structure - all consist of strings of CCP domains. Turns out the CCP domain family is massively (and uniquely) expanded in the Hpb genome.