The Helix Brief
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Heliix Brief delivers fast, accessible updates on the latest biomedical research. We scan new papers published in Europe PMC and bring you clear, concise digests focused on relevance and impact.
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November 11, 2025 at 2:51 PM
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These insights into the molecular architecture and dynamic behavior of the T9SS machinery advance our understanding of bacterial protein secretion mechanisms, which are crucial for processes like gliding motility and the secretion of virulence factors.
November 11, 2025 at 2:51 PM
These insights into the molecular architecture and dynamic behavior of the T9SS machinery advance our understanding of bacterial protein secretion mechanisms, which are crucial for processes like gliding motility and the secretion of virulence factors.
Further analysis suggests that the PorKN complex undergoes conformational changes during substrate transport, transitioning between 50° and 90° states relative to the membrane plane.
November 11, 2025 at 2:51 PM
Further analysis suggests that the PorKN complex undergoes conformational changes during substrate transport, transitioning between 50° and 90° states relative to the membrane plane.
The findings reveal that the PorK subunit contains a repurposed formylglycine-generating enzyme-like fold, which serves as a structural hub for complex assembly. The complex exhibits a 33-fold symmetry, with PorK and PorN forming two tightly packed and wedged subrings.
November 11, 2025 at 2:51 PM
The findings reveal that the PorK subunit contains a repurposed formylglycine-generating enzyme-like fold, which serves as a structural hub for complex assembly. The complex exhibits a 33-fold symmetry, with PorK and PorN forming two tightly packed and wedged subrings.
This study used cryo-electron microscopy to determine the high-resolution structure of the PorKN ring complex, a crucial component of the type IX secretion system (T9SS) in the bacterium Porphyromonas gingivalis.
November 11, 2025 at 2:51 PM
This study used cryo-electron microscopy to determine the high-resolution structure of the PorKN ring complex, a crucial component of the type IX secretion system (T9SS) in the bacterium Porphyromonas gingivalis.
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November 11, 2025 at 2:31 PM
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The SAS can be a valuable asset in monitoring progress in acceptance and commitment therapy, as well as mindfulness-based interventions for sleep issues.
November 11, 2025 at 2:31 PM
The SAS can be a valuable asset in monitoring progress in acceptance and commitment therapy, as well as mindfulness-based interventions for sleep issues.
While the SAS demonstrated temporal stability, it lacked configural invariance between good and poor sleepers, suggesting potential differences in how sleep acceptance manifests across these groups.
November 11, 2025 at 2:31 PM
While the SAS demonstrated temporal stability, it lacked configural invariance between good and poor sleepers, suggesting potential differences in how sleep acceptance manifests across these groups.
Through a rigorous process involving 1,350 participants, the study established the scale's unidimensional structure, high internal consistency, and strong convergent validity with measures of insomnia, anxiety, and depression.
November 11, 2025 at 2:31 PM
Through a rigorous process involving 1,350 participants, the study established the scale's unidimensional structure, high internal consistency, and strong convergent validity with measures of insomnia, anxiety, and depression.
The researchers developed the Sleep Acceptance Scale (SAS) to measure an individual's cognitive and emotional responses to sleep problems.
November 11, 2025 at 2:31 PM
The researchers developed the Sleep Acceptance Scale (SAS) to measure an individual's cognitive and emotional responses to sleep problems.
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November 11, 2025 at 2:11 PM
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These findings demonstrate the potential of DCT and digital technologies to transform early-stage clinical trials, enabling more efficient and patient-centric research.
November 11, 2025 at 2:11 PM
These findings demonstrate the potential of DCT and digital technologies to transform early-stage clinical trials, enabling more efficient and patient-centric research.
The study found that PK results, safety, and tolerability data collected remotely through the DCT framework were comparable to those from a conventional on-site study. The use of wearable devices allowed for real-time remote monitoring of participants.
November 11, 2025 at 2:11 PM
The study found that PK results, safety, and tolerability data collected remotely through the DCT framework were comparable to those from a conventional on-site study. The use of wearable devices allowed for real-time remote monitoring of participants.
Eight healthy participants underwent two treatment periods: Period 1 with practice sessions for wearable devices and PK sampling, and Period 2 without practice sessions.
November 11, 2025 at 2:11 PM
Eight healthy participants underwent two treatment periods: Period 1 with practice sessions for wearable devices and PK sampling, and Period 2 without practice sessions.
This study explored the feasibility of a hybrid decentralized clinical trial (DCT) design for a Phase 1 study of the drug etrasimod.
November 11, 2025 at 2:11 PM
This study explored the feasibility of a hybrid decentralized clinical trial (DCT) design for a Phase 1 study of the drug etrasimod.
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November 11, 2025 at 1:51 PM
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These findings offer valuable insights into the potential of autolysins as novel therapeutic agents against this challenging pathogen, though additional research is needed to explore their broader applicability and limitations.
November 11, 2025 at 1:51 PM
These findings offer valuable insights into the potential of autolysins as novel therapeutic agents against this challenging pathogen, though additional research is needed to explore their broader applicability and limitations.
The high-resolution crystal structure of the endopeptidase domain revealed a substrate-binding groove with the catalytic residues Cys242 and His296. Modeling and mutagenic analyses further elucidated the enzyme-substrate interaction.
November 11, 2025 at 1:51 PM
The high-resolution crystal structure of the endopeptidase domain revealed a substrate-binding groove with the catalytic residues Cys242 and His296. Modeling and mutagenic analyses further elucidated the enzyme-substrate interaction.
The researchers expressed, purified, and assayed the entire protein and its individual domains, finding that only the endopeptidase domain exhibited bacteriolytic activity against C. difficile.
November 11, 2025 at 1:51 PM
The researchers expressed, purified, and assayed the entire protein and its individual domains, finding that only the endopeptidase domain exhibited bacteriolytic activity against C. difficile.
This study delves into the biochemical and structural characteristics of the putative autolysin CdCwlT33800 from Clostridioides difficile, a major cause of pseudomembranous colitis.
November 11, 2025 at 1:51 PM
This study delves into the biochemical and structural characteristics of the putative autolysin CdCwlT33800 from Clostridioides difficile, a major cause of pseudomembranous colitis.
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November 11, 2025 at 1:31 PM
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