Ingo Hartung
@hartungingo.bsky.social
discovery chemistry nerd @Merckgroup; oncology, immunology, targeted protein degradation, ADCs; soccer, politics, tapas can slip into the feed; my own views
Hi all, our old #sciencetwitter party place is reopening. Just in case you didn‘t get the invite… bring your Popcorn!
June 5, 2025 at 9:03 PM
Hi all, our old #sciencetwitter party place is reopening. Just in case you didn‘t get the invite… bring your Popcorn!
Guess who is sitting in front of me…
April 29, 2025 at 12:00 AM
Guess who is sitting in front of me…
Life could be worse… unfortunately, a pretty busy working week ahead.
April 6, 2025 at 10:51 AM
Life could be worse… unfortunately, a pretty busy working week ahead.
First impressions of comparing #AACR25 coverage on Bluesky with the other place. I am used to check the conference handle regularly to build my conference schedule. Some interesting findings on Twitter, nothing here yet. I hope conference coverage will pick up here as well.
April 6, 2025 at 10:27 AM
First impressions of comparing #AACR25 coverage on Bluesky with the other place. I am used to check the conference handle regularly to build my conference schedule. Some interesting findings on Twitter, nothing here yet. I hope conference coverage will pick up here as well.
She spoke of a genocide committed against the Palestinians.
March 22, 2025 at 10:35 AM
She spoke of a genocide committed against the Palestinians.
Still difficult for me to judge the reach of this platform. #AACR25 (5 weeks from now) will be the 1st real test for science posting here. The meeting program is packed w/ sessions about novel ADC approaches, degraders/proximity inducers, targeting intracktables, overcoming resistance, using AI.
March 22, 2025 at 9:20 AM
Still difficult for me to judge the reach of this platform. #AACR25 (5 weeks from now) will be the 1st real test for science posting here. The meeting program is packed w/ sessions about novel ADC approaches, degraders/proximity inducers, targeting intracktables, overcoming resistance, using AI.
A bit more than one month til #AACR25 and two months til the ASCMEDI-EFMC symposium - both in Chicago. I never thought that traveling to the US may ever become an issue for political reasons. Let‘s see what the next weeks will bring…
March 20, 2025 at 9:13 PM
A bit more than one month til #AACR25 and two months til the ASCMEDI-EFMC symposium - both in Chicago. I never thought that traveling to the US may ever become an issue for political reasons. Let‘s see what the next weeks will bring…
More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...
March 19, 2025 at 7:06 AM
More about rewiring transcription with bifunctional TCIP molecules: biological proof-of-concept in sarcoma cell lines www.biorxiv.org/content/10.1...
This one is more challenging… still to early to give an assessment.
March 9, 2025 at 7:17 PM
This one is more challenging… still to early to give an assessment.
What a book! Very well deserved Booker Prize. Must-read recommendation. #ChemistsWhoRead
March 8, 2025 at 2:43 PM
What a book! Very well deserved Booker Prize. Must-read recommendation. #ChemistsWhoRead
Tja, das ist mal ein Romanbeginn, der meine Aufmerksamkeit schon im ersten Satz gewonnen hat…
March 1, 2025 at 4:00 PM
Tja, das ist mal ein Romanbeginn, der meine Aufmerksamkeit schon im ersten Satz gewonnen hat…
Small molecular weight drug molecules are products of design. Multiple characteristics are designed into one chemical structure. Read about how the combination of experimental data with calculated properties streamlines the discovery of oral designer PROTACs:
pubs.rsc.org/en/content/a...
@rsc.org
pubs.rsc.org/en/content/a...
@rsc.org
February 22, 2025 at 10:03 AM
Small molecular weight drug molecules are products of design. Multiple characteristics are designed into one chemical structure. Read about how the combination of experimental data with calculated properties streamlines the discovery of oral designer PROTACs:
pubs.rsc.org/en/content/a...
@rsc.org
pubs.rsc.org/en/content/a...
@rsc.org
Visiting #Irsee2025 was again a true pleasure. Not only the great science in a unique environment. But also the truly Bavarian weather, food & beer! Already looking forward to 25th til 27th February 2026 for #Irsee2026! @dechema.bsky.social
February 21, 2025 at 8:59 AM
Visiting #Irsee2025 was again a true pleasure. Not only the great science in a unique environment. But also the truly Bavarian weather, food & beer! Already looking forward to 25th til 27th February 2026 for #Irsee2026! @dechema.bsky.social
More biocatalysis at #Irsee2025. It took us a few years to bring Uwe Bornscheuer all the way from the baltic sea to south-western Bavaria. But it was worth the wait… reengineering methyl transferases and monooxygenases. @dechema.bsky.social
February 21, 2025 at 8:45 AM
More biocatalysis at #Irsee2025. It took us a few years to bring Uwe Bornscheuer all the way from the baltic sea to south-western Bavaria. But it was worth the wait… reengineering methyl transferases and monooxygenases. @dechema.bsky.social
The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!
February 21, 2025 at 7:55 AM
The new perspective from the @euromedchem.bsky.social Best Practice Initiative is now online: chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1... Best practice recommendations for the optimization from a Hit to a Lead. Kudos to Bob Young & Jean Quancard for driving this initiative!
The power & coolness of biocatalysis at #Irsee2025: Rebecca Buller from Zurich University of Applied Sciences about strategies to evolve designer enzymes. Enabling the chlorination of the complex macrolide soraphen and the derivatization of terpenes.
February 21, 2025 at 7:49 AM
The power & coolness of biocatalysis at #Irsee2025: Rebecca Buller from Zurich University of Applied Sciences about strategies to evolve designer enzymes. Enabling the chlorination of the complex macrolide soraphen and the derivatization of terpenes.
Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
February 11, 2025 at 2:06 PM
Talking about VHL-based #PROTACs: Check out our newest publication from the @proxidrugs.bsky.social consortium in which we propose & exemplify a generalizable workflow for the validation of E3 ligands for developing PROTACs.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Still all fine on this side of the sea of greenland (formerly known as the atlantic ocean).
February 11, 2025 at 6:48 AM
Still all fine on this side of the sea of greenland (formerly known as the atlantic ocean).
There are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...
February 10, 2025 at 9:45 PM
There are many reasons for drug discovery scientists to be interested in #PROTACs. VHL-based PROTACs should not be ignored, there are important use cases for them. @alessiociulli.bsky.social & colleagues now compiled the VHL ligand chemical space in this paper: www.tandfonline.com/doi/pdf/10.1...
Und noch eine Roman-Empfehlung mit aktuellem Bezug: Arnold Zweigs Roman “De Vriedt kehrt heim” über einen politischen Mord im britischen Mandatsgebiet Palästina (Erstveröffentlichung 1932!). Neuausgabe aus 2024 der Anderen Bibliothek. Über die Ursprünge des israelisch-palästinensischen Konflikts.
January 26, 2025 at 10:47 AM
Und noch eine Roman-Empfehlung mit aktuellem Bezug: Arnold Zweigs Roman “De Vriedt kehrt heim” über einen politischen Mord im britischen Mandatsgebiet Palästina (Erstveröffentlichung 1932!). Neuausgabe aus 2024 der Anderen Bibliothek. Über die Ursprünge des israelisch-palästinensischen Konflikts.
Nach längerer Pause gestern mal wieder im Theater: Faust 1&2 im Schauspiel Frankfurt, Regie Jan-Christoph Gockel, mit “Kommissar Brix” als Mephisto. 4h modernes, multimediales, sehr kurzweiliges Theater. Textkenntnis hilft, kann aber durch die Einführung ersetzt werden. Wieder im März & April.
January 26, 2025 at 9:42 AM
Nach längerer Pause gestern mal wieder im Theater: Faust 1&2 im Schauspiel Frankfurt, Regie Jan-Christoph Gockel, mit “Kommissar Brix” als Mephisto. 4h modernes, multimediales, sehr kurzweiliges Theater. Textkenntnis hilft, kann aber durch die Einführung ersetzt werden. Wieder im März & April.
Appropriate reading during these tumultuous days: „Twilight of Democracy“ by @anneapplebaum.bsky.social. A few teasers below for those interested in thinking about the historical perspective for the destructive centrifugal forces currently visible in all Western democracies. amzn.eu/d/1m8dE4G
January 25, 2025 at 10:24 AM
Appropriate reading during these tumultuous days: „Twilight of Democracy“ by @anneapplebaum.bsky.social. A few teasers below for those interested in thinking about the historical perspective for the destructive centrifugal forces currently visible in all Western democracies. amzn.eu/d/1m8dE4G
Sunset are always spectacular when you are at the coast in the south.
January 19, 2025 at 7:27 AM
Sunset are always spectacular when you are at the coast in the south.
In preparation for the inauguration on Monday I ask myself what has happened in the 16 years since this speech: youtu.be/HcOgwJ9uAMQ?...
Since the days of cooperation across the aisle.
Astonishing that we would look back at George W Bush this way.
Since the days of cooperation across the aisle.
Astonishing that we would look back at George W Bush this way.
January 14, 2025 at 7:59 PM
In preparation for the inauguration on Monday I ask myself what has happened in the 16 years since this speech: youtu.be/HcOgwJ9uAMQ?...
Since the days of cooperation across the aisle.
Astonishing that we would look back at George W Bush this way.
Since the days of cooperation across the aisle.
Astonishing that we would look back at George W Bush this way.