Harry Wilders
@harrywilders.bsky.social
GSK/Francis Crick Institute Industrial Post-Doctoral Researcher exploring chemoproteomics approaches to covalent drug discovery
Pinned
Harry Wilders
@harrywilders.bsky.social
· Dec 11
Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening
Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive frag...
onlinelibrary.wiley.com
I am happy to share that our recent work has been published in Angewandte Chemie.
We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.
onlinelibrary.wiley.com/doi/full/10....
We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.
onlinelibrary.wiley.com/doi/full/10....
Reposted by Harry Wilders
Check out our new paper in @commschem.bsky.social, where we identified a novel enantioselective fragment for the deubiquitinating enzyme, OTUD7B. An absolute pleasure to co-lead this project with Aini Vuorinen and @cassandrakennedy.bsky.social!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
January 15, 2025 at 2:44 PM
Check out our new paper in @commschem.bsky.social, where we identified a novel enantioselective fragment for the deubiquitinating enzyme, OTUD7B. An absolute pleasure to co-lead this project with Aini Vuorinen and @cassandrakennedy.bsky.social!
www.nature.com/articles/s42...
www.nature.com/articles/s42...
Excited to see this out in Nature Communications. A great platform to profile reactive fragments against the human proteome (and beyond), quickly and accurately.
#ChemBio #Chemsky
#ChemBio #Chemsky
Excited to share a key part of my postdoctoral work from @crick.ac.uk and GSK, published in Nature Communications. A collaborative project to develop a high-throughput chemoproteomics platform for profiling cysteine-reactive fragments in native biological systems.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Robust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - Nature Communications
This paper presents a label-free chemoproteomics platform using data-independent acquisition to profile covalent fragment binding across the human proteome. The platform offers high reproducibility an...
www.nature.com
January 11, 2025 at 8:36 PM
Reposted by Harry Wilders
Interested in a PhD combining high-throughput synthesis, structural and cell biology to understand kinases? Deadline to apply for a project with Richard Bayliss, Helen Matthews and me: January 6th! www.findaphd.com/phds/project...
Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds on FindAPhD.com
PhD Project - Probing covalent mechanisms of regulation and inhibition in mitotic kinases at University of Leeds, listed on FindAPhD.com
www.findaphd.com
December 28, 2024 at 5:12 PM
Interested in a PhD combining high-throughput synthesis, structural and cell biology to understand kinases? Deadline to apply for a project with Richard Bayliss, Helen Matthews and me: January 6th! www.findaphd.com/phds/project...
I am happy to share that our recent work has been published in Angewandte Chemie.
We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.
onlinelibrary.wiley.com/doi/full/10....
We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.
onlinelibrary.wiley.com/doi/full/10....
Expedited SARS‐CoV‐2 Main Protease Inhibitor Discovery through Modular ‘Direct‐to‐Biology’ Screening
Direct-to-biology workflows promise to accelerate hit optimisation for drug discovery. Here, we describe a direct-to-biology method for the efficient synthesis and screening of cysteine-reactive frag...
onlinelibrary.wiley.com
December 11, 2024 at 5:50 PM
I am happy to share that our recent work has been published in Angewandte Chemie.
We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.
onlinelibrary.wiley.com/doi/full/10....
We demonstrate how ‘direct-to-biology’ screening can accelerate optimisation campaigns, yielding potent covalent and non-covalent inhibitors from reactive fragment hits.
onlinelibrary.wiley.com/doi/full/10....
Reposted by Harry Wilders
ChemBio fans please repost the #ChemicalBiology Feed bsky.app/profile/thor...
@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social
#chemsky
@carolynbertozzi.bsky.social @ritastrack.bsky.social @stephanhacker2.bsky.social @stuartcantrill.bsky.social @laurahowes.bsky.social @dirktrauner.bsky.social @chemjobber.bsky.social @dereklowe.bsky.social
#chemsky
November 25, 2024 at 1:02 AM