Harry Orrin
@harryorrin.bsky.social
PhD student studying DNA replication🧬 in Yeeles group at MRC-LMB
Reposted by Harry Orrin
I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉
October 14, 2025 at 11:09 AM
I’m really excited to share that I’ve been awarded a Wellcome Trust Career Development Award to start my own research group at Oxford University Biochemistry Department @BiochemOxford 🧬🎉
Reposted by Harry Orrin
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴
www.biochemistry.org/events-and-t...
www.biochemistry.org/events-and-t...
UK DNA Replication Meeting 2026
Research in the DNA replication field is progressing at a remarkable rate. Technological innovations in biochemical reconstitution, structural biology, proteomics and DNA sequencing are helping to rap...
www.biochemistry.org
April 15, 2025 at 10:30 AM
3rd edition of the fantastic UK DNA replication meeting is happening next September in Edinburgh. Don't miss out 🧬🏴
www.biochemistry.org/events-and-t...
www.biochemistry.org/events-and-t...
Reposted by Harry Orrin
Great new work from the very talented Emma Fletcher (@Yeeles_Lab). Biochemistry, and a touch of cryoEM, reveal why the DNA replication machinery needs a dedicated leading strand PCNA clamp loader. 🧬🧪🥼🔬🧑🔬
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....
Competition for the nascent leading strand shapes the requirements for PCNA loading in the replisome | The EMBO Journal
imageimageCtf18-RFC is a dedicated leading-strand replication clamp loader, with RFC unable
to fulfil this role. This study provides a mechanistic basis as to why this is the
case and reveals unique f...
www.embopress.org
March 19, 2025 at 12:42 PM
Great new work from the very talented Emma Fletcher (@Yeeles_Lab). Biochemistry, and a touch of cryoEM, reveal why the DNA replication machinery needs a dedicated leading strand PCNA clamp loader. 🧬🧪🥼🔬🧑🔬
www.embopress.org/doi/full/10....
www.embopress.org/doi/full/10....