Harris Wang
@harriswang.bsky.social
Professor and Interim Chair | Dept. of Systems Biology | Columbia University | Synthetic Biology | Microbiome | Genome Engineering
http://wanglab.c2b2.columbia.edu
http://wanglab.c2b2.columbia.edu
Pinned
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
November 15, 2025 at 4:02 AM
📢 Our Dept. of Systems Biology at Columbia University has an open tenure-track Assistant Professor position in the broad area of quantitative biology. Come join our awesome department in NYC! Please circulate.
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
apply.interfolio.com/177622
Suggested deadline: 12/15/2025.
@columbiasysbio.bsky.social
Reposted by Harris Wang
1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge.
Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...
Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
science.org
November 14, 2025 at 2:25 PM
1/9 Metagenomics lets us read microbiomes in nature without cultivation, but writing (editing) them in their native context is still a major challenge.
Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...
Meet MetaEdit: a platform for pathway-scale metagenomic editing inside the gut microbiome. science.org/doi/10.1126/...
Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Metagenomic editing of commensal bacteria in vivo using CRISPR-associated transposases
Although metagenomic sequencing has revealed a rich microbial biodiversity in the mammalian gut, methods to genetically alter specific species in the microbiome are highly limited. Here, we introduce ...
www.science.org
November 13, 2025 at 8:53 PM
Very excited to share our latest work in Science on metagenomic editing (MetaEdit) of the gut microbiome in vivo & directly modifying unculturable immune-modulatory SFB bug in the small intestine. 🦠🧬🛠️
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Grateful to work with the wonderful
@vilcekfoundation.bsky.social and the super talented Hiroki Otsuka on a short manga highlighting our research and my journey as an immigrant scientist! 🧪🦠🧬
vilcek.org/news/microbe...
@vilcekfoundation.bsky.social and the super talented Hiroki Otsuka on a short manga highlighting our research and my journey as an immigrant scientist! 🧪🦠🧬
vilcek.org/news/microbe...
Biographical Manga Highlights Scientist Harris Wang’s Superhero Microbiome Work
Discover how immigrant scientist Harris Wang, PhD, uses synthetic biology to reprogram gut bacteria in this manga by Hiroki Otsuka.
vilcek.org
June 25, 2025 at 12:32 PM
Grateful to work with the wonderful
@vilcekfoundation.bsky.social and the super talented Hiroki Otsuka on a short manga highlighting our research and my journey as an immigrant scientist! 🧪🦠🧬
vilcek.org/news/microbe...
@vilcekfoundation.bsky.social and the super talented Hiroki Otsuka on a short manga highlighting our research and my journey as an immigrant scientist! 🧪🦠🧬
vilcek.org/news/microbe...
Yikes… NIH dropping IC to 15%
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD
grants.nih.gov
February 8, 2025 at 12:59 AM
Yikes… NIH dropping IC to 15%
grants.nih.gov/grants/guide...
grants.nih.gov/grants/guide...
Happy to share our new paper in @naturemicrobiol.bsky.social on mapping spatial relationships of the human gut microbiome. We identified distinct spatial hubs between gut bacteria that reflect sub-community assemblies at the micron-scale. Led by Miles Richardson & co.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome - Nature Microbiology
Split-And-pool Metagenomic Plot-sampling sequencing (SAMPL-seq) can be applied to complex microbial communities to reveal spatial co-localization of microbes at the micron scale.
www.nature.com
February 3, 2025 at 2:46 PM
Happy to share our new paper in @naturemicrobiol.bsky.social on mapping spatial relationships of the human gut microbiome. We identified distinct spatial hubs between gut bacteria that reflect sub-community assemblies at the micron-scale. Led by Miles Richardson & co.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
💡💥Here’s a modest proposal I’ve been pondering for a while on how to change the PEER REVIEW process and start more community-driven SCIENCE FUNDING. Lots of feedback/discussion welcomed! Other variants of the idea might exist already—not claiming originality. (a long 🧵) (1/9)
November 30, 2024 at 5:14 AM
💡💥Here’s a modest proposal I’ve been pondering for a while on how to change the PEER REVIEW process and start more community-driven SCIENCE FUNDING. Lots of feedback/discussion welcomed! Other variants of the idea might exist already—not claiming originality. (a long 🧵) (1/9)
One under-appreciated challenge of mid-career PI’s is that after a decade or more, the big equipments you originally bought all break down and need replacement. People don’t necessarily have discretionary funds at this point and it’s hard to bootstrap through grants.
November 19, 2024 at 12:51 PM
One under-appreciated challenge of mid-career PI’s is that after a decade or more, the big equipments you originally bought all break down and need replacement. People don’t necessarily have discretionary funds at this point and it’s hard to bootstrap through grants.
New paper from the lab out in Cell Systems. “Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut”
www.cell.com/cell-systems...
www.cell.com/cell-systems...
Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut
Fecal microbiota transplantation (FMT) therapies hold promise but suffer from variable
transplantation efficiencies. Here, we examine microbiome spatiotemporal dynamics
post-FMT with a super-colonizin...
www.cell.com
November 17, 2024 at 6:41 PM
New paper from the lab out in Cell Systems. “Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut”
www.cell.com/cell-systems...
www.cell.com/cell-systems...