Harrison Specht
@harrisons.bsky.social
Exploring biology with mass spectrometry
When that mass spectrometry data gives Patrick vibes ...
(so sorry in advance, couldn't resist)
(so sorry in advance, couldn't resist)
September 25, 2025 at 3:24 PM
When that mass spectrometry data gives Patrick vibes ...
(so sorry in advance, couldn't resist)
(so sorry in advance, couldn't resist)
PSM tag also enhances de novo sequencing of challenging peptides, unlocking promise for immunopeptidomics studies.
May 28, 2025 at 12:24 PM
PSM tag also enhances de novo sequencing of challenging peptides, unlocking promise for immunopeptidomics studies.
📊 Using stable isotopes of C/N/O, PSMtags increased protein datapoints from 4,340 (label-free) to 28,359 in the same time. We demonstrate 240 samples per day, but over 1,000 are possible with shorter runs.
That’s millions of protein data points per day.
That’s millions of protein data points per day.
May 28, 2025 at 12:24 PM
📊 Using stable isotopes of C/N/O, PSMtags increased protein datapoints from 4,340 (label-free) to 28,359 in the same time. We demonstrate 240 samples per day, but over 1,000 are possible with shorter runs.
That’s millions of protein data points per day.
That’s millions of protein data points per day.
PSMtags boost b-ion production, enhance de novo sequencing, and enable 9-plexDIA—without sacrificing quant accuracy.
May 28, 2025 at 12:23 PM
PSMtags boost b-ion production, enhance de novo sequencing, and enable 9-plexDIA—without sacrificing quant accuracy.
🔬 To find a tag that improves peptide fragmentation, we used split-pool synthesis to create a 576-compound library of peptide-bound tags. The best performer was PSMtag.
May 28, 2025 at 12:23 PM
🔬 To find a tag that improves peptide fragmentation, we used split-pool synthesis to create a 576-compound library of peptide-bound tags. The best performer was PSMtag.