You can read more here: shorturl.at/JCcyC

🌟 Special thanks to my opponent Assoc. Prof and Chief Physician Aleksi Tornio from the University of Turku and the Turku University Hospital for the great discussion.

🙏 I am deeply grateful to all biobank participants whose data made this research possible, and to the funders who supported our work.

🧬 My research focused on improving the understanding of genetic factors influencing medication use patterns and side effects, using large-scale @estbiobank.bsky.social. This work contributes to the bigger goal of personalised and safer pharmacotherapy for everyone.

(4/4)
Huge thanks to participants and collaborators who made this research possible Dage Särg, @kristikrebs.bsky.social , Maarja Jõeloo, @kadrikoiv.bsky.social , Kairit Sirts, Maris Alver, @klehto.bsky.social , @lilimilani.bsky.social

(3/4) Findings
🔬 Genetic predisposition to the underlying trait (e.g., higher BMI) is associated with an increased risk of the corresponding side effect (e.g., weight gain).

A better understanding of antidepressant tolerability can help guide drug and dose choice, improving treatment outcomes.

(2/4) Findings:
🧬 CYP2C19 genetic variation has a role in the burden of side effects experienced by individuals taking antidepressants.

🧠 Genetic predisposition to certain psychiatric traits is linked to a higher burden and specific side effects from most antidepressant classes.