Joe Hanly
@hanliconius.bsky.social
interested in evolution, development and butterflies. Smithsonian Postdoc fellow. #albinism. He/him 🏳️🌈
More journeys through fly gene etymologies.
![Screenshot of a Wikipedia article History article with the following text: The protein was discovered in 1996 by Italian scientists Silvia Bione et al., after long and intensive work.[15] Owing to the complex procedure required for the identification of tafazzin, the protein was named after Tafazzi, an Italian comedy character played by Giacomo Poretti who enthusiastically beats his groin with a plastic bottle, this as a symbol of masochism for the strenuous will to find it by the group of researchers.[77]](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:b3t6tkvujvmh5t7d3dhok52t/bafkreig5kgwrxfhiylt7gog45bokmby6ju2isssczh4ubnlog76hoggm4m@jpeg)
October 20, 2025 at 7:49 PM
More journeys through fly gene etymologies.
With the exception of echinoderms, the zygote never really has a diploid genome. The first time we have what I think you could call the true diploid genome of a new individual within a nucleus, is almost always at the 2-cell stage, NOT the one cell stage. Make of that what you will. 13/
May 30, 2025 at 6:51 PM
With the exception of echinoderms, the zygote never really has a diploid genome. The first time we have what I think you could call the true diploid genome of a new individual within a nucleus, is almost always at the 2-cell stage, NOT the one cell stage. Make of that what you will. 13/
The two pronuclei then, completely separately (but in apposition), enter S-phase, each becoming diploid for the parental genome. (?!?) then a completely separate (though again apposed) mitosis occurs, with two sets of spindles, in which the chromosomes do not 'mix'. 9/
May 30, 2025 at 6:51 PM
The two pronuclei then, completely separately (but in apposition), enter S-phase, each becoming diploid for the parental genome. (?!?) then a completely separate (though again apposed) mitosis occurs, with two sets of spindles, in which the chromosomes do not 'mix'. 9/
Here's a schematic representation of that, borrowed along with the other figures so far from Loppin et al 2015 doi: 10.1098/rsob.150076 8/
May 30, 2025 at 6:51 PM
Here's a schematic representation of that, borrowed along with the other figures so far from Loppin et al 2015 doi: 10.1098/rsob.150076 8/
Here's how it goes in insects: Sperm enters egg. Egg has the four pronuclei produced by meiosis. The sperm centrosome “captures” one of the pronuclei (the others become polar bodies). Ok nothing too weird yet. 7/
May 30, 2025 at 6:51 PM
Here's how it goes in insects: Sperm enters egg. Egg has the four pronuclei produced by meiosis. The sperm centrosome “captures” one of the pronuclei (the others become polar bodies). Ok nothing too weird yet. 7/
Then sperm pronucleus and the egg pronucleus fuse together, forming a single celled zygote with a diploid genome. Mitosis then begins. In this image you can see pronuclear fusion in action 3/
May 30, 2025 at 6:51 PM
Then sperm pronucleus and the egg pronucleus fuse together, forming a single celled zygote with a diploid genome. Mitosis then begins. In this image you can see pronuclear fusion in action 3/
Animal fertilization occurs roughly like this: a sperm, with a haploid genome in its pronucleus, enters an egg. The sperm pronucleus then comes into contact with the egg pronucleus (and the 'polar body' nuclei - products of maternal meiosis, may still be hanging around, depending on the egg type) 2/
May 30, 2025 at 6:51 PM
Animal fertilization occurs roughly like this: a sperm, with a haploid genome in its pronucleus, enters an egg. The sperm pronucleus then comes into contact with the egg pronucleus (and the 'polar body' nuclei - products of maternal meiosis, may still be hanging around, depending on the egg type) 2/
Martin Lab, c. May 2025
May 14, 2025 at 8:04 PM
Martin Lab, c. May 2025
Google: AI search will change the world
The change:
The change:
February 25, 2025 at 5:09 PM
Google: AI search will change the world
The change:
The change:
hard to imagine a more humiliating headline for the US
February 24, 2025 at 5:24 PM
hard to imagine a more humiliating headline for the US
it's been known for a long time that Urchins can respond to ablation of micromeres by trans-fating some cell lineages, allowing them to largely recover. @urchinpapi.bsky.social studied this using a dense single cell RNA seq time series: 2/3
January 28, 2025 at 8:08 PM
it's been known for a long time that Urchins can respond to ablation of micromeres by trans-fating some cell lineages, allowing them to largely recover. @urchinpapi.bsky.social studied this using a dense single cell RNA seq time series: 2/3
awesome new paper @urchinpapi.bsky.social: journals.biologists.com/dev/article/... 1/3
January 28, 2025 at 8:08 PM
awesome new paper @urchinpapi.bsky.social: journals.biologists.com/dev/article/... 1/3
Turns out, do meet your heroes. @lucalivraghi.bsky.social @donyaniyaz.bsky.social
December 6, 2024 at 7:06 PM
Turns out, do meet your heroes. @lucalivraghi.bsky.social @donyaniyaz.bsky.social
Turns out a lot of people don’t know these things are called Daleks? At least, they were when I worked in Somerfields.
December 6, 2024 at 12:25 AM
Turns out a lot of people don’t know these things are called Daleks? At least, they were when I worked in Somerfields.
HCR identified pattern-related expression of pdm3 in SOPs in the early pupal wing. Knocking out pdm3 in the painted lady butterfly led to large effects in wing color patterning, but normal SOP differentiation into scale- and socket-building cells.
June 3, 2024 at 10:27 PM
HCR identified pattern-related expression of pdm3 in SOPs in the early pupal wing. Knocking out pdm3 in the painted lady butterfly led to large effects in wing color patterning, but normal SOP differentiation into scale- and socket-building cells.
we found a gene pdm3, with no known previous roles in SOP differentiation, enriched in the cluster of SOPs and absent in clusters for scale- and socket-building cells.
June 3, 2024 at 10:26 PM
we found a gene pdm3, with no known previous roles in SOP differentiation, enriched in the cluster of SOPs and absent in clusters for scale- and socket-building cells.
We present the first time-series snRNAseq data, with temporal resolution showing hallmarks of SOP differentiation and division. This approach also allows us to discover novel components involved in the specification of scale cells, for example:
June 3, 2024 at 10:25 PM
We present the first time-series snRNAseq data, with temporal resolution showing hallmarks of SOP differentiation and division. This approach also allows us to discover novel components involved in the specification of scale cells, for example:
We confirmed our cell types by corroborating in situ expression and functional validation of several candidate genes. In combo with live imaging this shows that lep scale cells derive from SOPs in a manner similar to how in the known canonical lineage mechanosensory bristles derive from SOPs
June 3, 2024 at 10:25 PM
We confirmed our cell types by corroborating in situ expression and functional validation of several candidate genes. In combo with live imaging this shows that lep scale cells derive from SOPs in a manner similar to how in the known canonical lineage mechanosensory bristles derive from SOPs
We collected Heliconius butterfly wing samples from Panama and performed single-nuclei RNAseq in early pupae from 10 to 30% development. We were able to confidently identify developing SOP, scale- and socket-building cells via sets of canonical markers including TFs, Notch pathway, and CAMs.
June 3, 2024 at 10:24 PM
We collected Heliconius butterfly wing samples from Panama and performed single-nuclei RNAseq in early pupae from 10 to 30% development. We were able to confidently identify developing SOP, scale- and socket-building cells via sets of canonical markers including TFs, Notch pathway, and CAMs.
New preprint alert from @lings_ll, @Hanliconius and @KyleDeMarr with the Martin, Wray and Patel labs. We are pleased to share our work outlining evidence for how lepidopteran scale cells are derived from sensory organ precursors (SOPs). www.biorxiv.org/content/10.1...
June 3, 2024 at 10:18 PM
New preprint alert from @lings_ll, @Hanliconius and @KyleDeMarr with the Martin, Wray and Patel labs. We are pleased to share our work outlining evidence for how lepidopteran scale cells are derived from sensory organ precursors (SOPs). www.biorxiv.org/content/10.1...
Martin Lab, c. December 2023
December 11, 2023 at 7:29 PM
Martin Lab, c. December 2023
